[ Publications | Publications before 2009 ]

A complete list of lab publications can be found on Google scholar.

Publications

Cejas, P., Li, L., O'Neill, N. K., Duarte, M., Rao, P., Bowden, M., Zhou, C. W., Mendiola, M., Burgos, E., Feliu, J., Moreno-Rubio, J., Guadalajara, H., Moreno, V., Garcia-Olmo, D., Bellmunt, J., Mullane, S., Hirsch, M., Sweeney, C. J., Richardson, A., Liu, X. S., Brown, M., Shivdasani, R. A., & Long, H. W. (2016). Chromatin immunoprecipitation from fixed clinical tissues reveals tumor-specific enhancer profiles. Nat Med, 22(6), 685-691. doi:10.1038/nm.4085

Du, Z., Sun, T., Hacisuleyman, E., Fei, T., Wang, X., Brown, M., Rinn, J. L., Lee, M. G., Chen, Y., Kantoff, P. W., & Liu, X. S. (2016). Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer. Nat Commun, 7, 10982. doi:10.1038/ncomms10982

Groner, A. C., Cato, L., de Tribolet-Hardy, J., Bernasocchi, T., Janouskova, H., Melchers, D., Houtman, R., Cato, A. C., Tschopp, P., Gu, L., Corsinotti, A., Zhong, Q., Fankhauser, C., Fritz, C., Poyet, C., Wagner, U., Guo, T., Aebersold, R., Garraway, L. A., Wild, P. J., Theurillat, J. P., & Brown, M. (2016). TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer. Cancer Cell, 29(6), 846-858. doi:10.1016/j.ccell.2016.04.012

Jeselsohn, R., Barry, W. T., Migliaccio, I., Biagioni, C., Zhao, J., de Tribolet-Hardy, J., Guarducci, C., Bonechi, M., Laing, N., Winer, E. P., Brown, M., Di Leo, A., & Malorni, L. (2016). TransCONFIRM: Identification of a genetic signature of response to fulvestrant in advanced hormone receptor positive breast cancer. Clin Cancer Res. doi:10.1158/1078-0432.CCR-16-0148

Jeselsohn, R., & Brown, M. (2016). How drug resistance takes shape. Elife, 5. doi:10.7554/eLife.14973

Labbe, D. P., Uetani, N., Vinette, V., Lessard, L., Aubry, I., Migon, E., Sirois, J., Haigh, J. J., Begin, L. R., Trotman, L. C., Paquet, M., & Tremblay, M. L. (2016). PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers. Cancer Res, 76(11), 3130-3135. doi:10.1158/0008-5472.CAN-15-1501

Malorni, L., Giuliano, M., Migliaccio, I., Wang, T., Creighton, C. J., Lupien, M., Fu, X., Hilsenbeck, S. G., Healy, N., De Angelis, C., Mazumdar, A., Trivedi, M. V., Massarweh, S., Gutierrez, C., De Placido, S., Jeselsohn, R., Brown, M., Brown, P. H., Osborne, C. K., & Schiff, R. (2016). Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance. Mol Cancer Res, 14(5), 470-481. doi:10.1158/1541-7786.MCR-15-0423

Mounir, Z., Korn, J. M., Westerling, T., Lin, F., Kirby, C. A., Schirle, M., McAllister, G., Hoffman, G., Ramadan, N., Hartung, A., Feng, Y., Kipp, D. R., Quinn, C., Fodor, M., Baird, J., Schoumacher, M., Meyer, R., Deeds, J., Buchwalter, G., Stams, T., Keen, N., Sellers, W. R., Brown, M., & Pagliarini, R. A. (2016). ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor. Elife, 5. doi:10.7554/eLife.13964

Shu, S., Lin, C. Y., He, H. H., Witwicki, R. M., Tabassum, D. P., Roberts, J. M., Janiszewska, M., Huh, S. J., Liang, Y., Ryan, J., Doherty, E., Mohammed, H., Guo, H., Stover, D. G., Ekram, M. B., Peluffo, G., Brown, J., D'Santos, C., Krop, I. E., Dillon, D., McKeown, M., Ott, C., Qi, J., Ni, M., Rao, P. K., Duarte, M., Wu, S. Y., Chiang, C. M., Anders, L., Young, R. A., Winer, E. P., Letai, A., Barry, W. T., Carroll, J. S., Long, H. W., Brown, M., Liu, X. S., Meyer, C. A., Bradner, J. E., & Polyak, K. (2016). Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer. Nature, 529(7586), 413-417. doi:10.1038/nature16508

Spangle, J. M., Dreijerink, K. M., Groner, A. C., Cheng, H., Ohlson, C. E., Reyes, J., Lin, C. Y., Bradner, J., Zhao, J. J., Roberts, T. M., & Brown, M. (2016). PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer. Cell Rep, 15(12), 2692-2704. doi:10.1016/j.celrep.2016.05.046

Tavera-Mendoza, L. E., & Brown, M. (2016). A less invasive method for orthotopic injection of breast cancer cells into the mouse mammary gland. Lab Anim. doi:10.1177/0023677216640706

Townsend, E. C., Murakami, M. A., Christodoulou, A., Christie, A. L., Koster, J., DeSouza, T. A., Morgan, E. A., Kallgren, S. P., Liu, H., Wu, S. C., Plana, O., Montero, J., Stevenson, K. E., Rao, P., Vadhi, R., Andreeff, M., Armand, P., Ballen, K. K., Barzaghi-Rinaudo, P., Cahill, S., Clark, R. A., Cooke, V. G., Davids, M. S., DeAngelo, D. J., Dorfman, D. M., Eaton, H., Ebert, B. L., Etchin, J., Firestone, B., Fisher, D. C., Freedman, A. S., Galinsky, I. A., Gao, H., Garcia, J. S., Garnache-Ottou, F., Graubert, T. A., Gutierrez, A., Halilovic, E., Harris, M. H., Herbert, Z. T., Horwitz, S. M., Inghirami, G., Intlekoffer, A. M., Ito, M., Izraeli, S., Jacobsen, E. D., Jacobson, C. A., Jeay, S., Jeremias, I., Kelliher, M. A., Koch, R., Konopleva, M., Kopp, N., Kornblau, S. M., Kung, A. L., Kupper, T. S., LaBoeuf, N., LaCasce, A. S., Lees, E., Li, L. S., Look, A. T., Murakami, M., Muschen, M., Neuberg, D., Ng, S. Y., Odejide, O. O., Orkin, S. H., Paquette, R. R., Place, A. E., Roderick, J. E., Ryan, J. A., Sallan, S. E., Shoji, B., Silverman, L. B., Soiffer, R. J., Steensma, D. P., Stegmaier, K., Stone, R. M., Tamburini, J., Thorner, A. R., van Hummelen, P., Wadleigh, M., Wiesmann, M., Weng, A. P., Wuerthner, J. U., Williams, D. A., Wollison, B. M., Lane, A. A., Letai, A., Bertagnolli, M. M., Ritz, J., Brown, M., Long, H., Aster, J. C., Shipp, M. A., Griffin, J. D., & Weinstock, D. M. (2016). The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell, 29(4), 574-586. doi:10.1016/j.ccell.2016.03.008

Xu, H., Xu, K., He, H. H., Zang, C., Chen, C. H., Chen, Y., Qin, Q., Wang, S., Wang, C., Hu, S., Li, F., Long, H., Brown, M., & Liu, X. S. (2016). Integrative Analysis Reveals the Transcriptional Collaboration between EZH2 and E2F1 in the Regulation of Cancer-Related Gene Expression. Mol Cancer Res, 14(2), 163-172. doi:10.1158/1541-7786.MCR-15-0313

Bailey, S. T., Westerling, T., & Brown, M. (2015). Loss of estrogen-regulated microRNA expression increases HER2 signaling and is prognostic of poor outcome in luminal breast cancer. Cancer Res, 75(2), 436-445. doi:10.1158/0008-5472.CAN-14-1041

Li, W., Koster, J., Xu, H., Chen, C. H., Xiao, T., Liu, J. S., Brown, M., & Liu, X. S. (2015). Quality control, modeling, and visualization of CRISPR screens with MAGeCK-VISPR. Genome Biol, 16, 281. doi:10.1186/s13059-015-0843-6

Pomerantz, M. M., Li, F., Takeda, D. Y., Lenci, R., Chonkar, A., Chabot, M., Cejas, P., Vazquez, F., Cook, J., Shivdasani, R. A., Bowden, M., Lis, R., Hahn, W. C., Kantoff, P. W., Brown, M., Loda, M., Long, H. W., & Freedman, M. L. (2015). The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis. Nat Genet, 47(11), 1346-1351. doi:10.1038/ng.3419

van Kruchten, M., de Vries, E. G., Glaudemans, A. W., van Lanschot, M. C., van Faassen, M., Kema, I. P., Brown, M., Schroder, C. P., de Vries, E. F., & Hospers, G. A. (2015). Measuring residual estrogen receptor availability during fulvestrant therapy in patients with metastatic breast cancer. Cancer Discov, 5(1), 72-81. doi:10.1158/2159-8290.CD-14-0697

Wang, H., Zang, C., Liu, X. S., & Aster, J. C. (2015). The role of Notch receptors in transcriptional regulation. J Cell Physiol, 230(5), 982-988. doi:10.1002/jcp.24872

Wang, J., Zhang, X., Beck, A. H., Collins, L. C., Chen, W. Y., Tamimi, R. M., Hazra, A., Brown, M., Rosner, B., & Hankinson, S. E. (2015). Alcohol Consumption and Risk of Breast Cancer by Tumor Receptor Expression. Horm Cancer, 6(5-6), 237-246. doi:10.1007/s12672-015-0235-0

Bailey, S. T., Miron, P. L., Choi, Y. J., Kochupurakkal, B., Maulik, G., Rodig, S. J., Tian, R., Foley, K. M., Bowman, T., Miron, A., Brown, M., Iglehart, J. D., & Biswas, D. K. (2014). NF-kappaB activation-induced anti-apoptosis renders HER2-positive cells drug resistant and accelerates tumor growth. Mol Cancer Res, 12(3), 408-420. doi:10.1158/1541-7786.MCR-13-0206-T

Cai, C., He, H. H., Gao, S., Chen, S., Yu, Z., Gao, Y., Chen, S., Chen, M. W., Zhang, J., Ahmed, M., Wang, Y., Metzger, E., Schule, R., Liu, X. S., Brown, M., & Balk, S. P. (2014). Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity. Cell Rep, 9(5), 1618-1627. doi:10.1016/j.celrep.2014.11.008

Cato, L., Neeb, A., Brown, M., & Cato, A. C. (2014). Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L. Nucl Recept Signal, 12, e005. doi:10.1621/nrs.12005

Chen, X., Iliopoulos, D., Zhang, Q., Tang, Q., Greenblatt, M. B., Hatziapostolou, M., Lim, E., Tam, W. L., Ni, M., Chen, Y., Mai, J., Shen, H., Hu, D. Z., Adoro, S., Hu, B., Song, M., Tan, C., Landis, M. D., Ferrari, M., Shin, S. J., Brown, M., Chang, J. C., Liu, X. S., & Glimcher, L. H. (2014). XBP1 promotes triple-negative breast cancer by controlling the HIF1alpha pathway. Nature, 508(7494), 103-107. doi:10.1038/nature13119

Gordon, F. K., Vallaster, C. S., Westerling, T., Iyer, L. K., Brown, M., & Schnitzler, G. R. (2014). Research resource: Aorta- and liver-specific ERalpha-binding patterns and gene regulation by estrogen. Mol Endocrinol, 28(8), 1337-1351. doi:10.1210/me.2013-1395

He, H. H., Meyer, C. A., Hu, S. S., Chen, M. W., Zang, C., Liu, Y., Rao, P. K., Fei, T., Xu, H., Long, H., Liu, X. S., & Brown, M. (2014). Refined DNase-seq protocol and data analysis reveals intrinsic bias in transcription factor footprint identification. Nat Methods, 11(1), 73-78. doi:10.1038/nmeth.2762

Hsieh, C. L., Fei, T., Chen, Y., Li, T., Gao, Y., Wang, X., Sun, T., Sweeney, C. J., Lee, G. S., Chen, S., Balk, S. P., Liu, X. S., Brown, M., & Kantoff, P. W. (2014). Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation. Proc Natl Acad Sci U S A, 111(20), 7319-7324. doi:10.1073/pnas.1324151111

Hu, Y., Petit, S. A., Ficarro, S. B., Toomire, K. J., Xie, A., Lim, E., Cao, S. A., Park, E., Eck, M. J., Scully, R., Brown, M., Marto, J. A., & Livingston, D. M. (2014). PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair. Cancer Discov, 4(12), 1430-1447. doi:10.1158/2159-8290.CD-13-0891

Jehle, K., Cato, L., Neeb, A., Muhle-Goll, C., Jung, N., Smith, E. W., Buzon, V., Carbo, L. R., Estebanez-Perpina, E., Schmitz, K., Fruk, L., Luy, B., Chen, Y., Cox, M. B., Brase, S., Brown, M., & Cato, A. C. (2014). Coregulator control of androgen receptor action by a novel nuclear receptor-binding motif. J Biol Chem, 289(13), 8839-8851. doi:10.1074/jbc.M113.534859

Jeselsohn, R., Yelensky, R., Buchwalter, G., Frampton, G., Meric-Bernstam, F., Gonzalez-Angulo, A. M., Ferrer-Lozano, J., Perez-Fidalgo, J. A., Cristofanilli, M., Gomez, H., Arteaga, C. L., Giltnane, J., Balko, J. M., Cronin, M. T., Jarosz, M., Sun, J., Hawryluk, M., Lipson, D., Otto, G., Ross, J. S., Dvir, A., Soussan-Gutman, L., Wolf, I., Rubinek, T., Gilmore, L., Schnitt, S., Come, S. E., Pusztai, L., Stephens, P., Brown, M., & Miller, V. A. (2014). Emergence of constitutively active estrogen receptor-alpha mutations in pretreated advanced estrogen receptor-positive breast cancer. Clin Cancer Res, 20(7), 1757-1767. doi:10.1158/1078-0432.CCR-13-2332

Li, W., Xu, H., Xiao, T., Cong, L., Love, M. I., Zhang, F., Irizarry, R. A., Liu, J. S., Brown, M., & Liu, X. S. (2014). MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens. Genome Biol, 15(12), 554. doi:10.1186/s13059-014-0554-4

Lim, E., Ni, M., Cao, S., Hazra, A., Tamimi, R. M., & Brown, M. (2014). Importance of Breast Cancer Subtype in the Development of Androgen Receptor Directed Therapy. Curr Breast Cancer Rep, 6(2), 71-78. doi:10.1007/s12609-014-0140-5

Yoo, S., Pettersson, A., Jordahl, K. M., Lis, R. T., Lindstrom, S., Meisner, A., Nuttall, E. J., Stack, E. C., Stampfer, M. J., Kraft, P., Brown, M., Loda, M., Giovannucci, E. L., Kantoff, P. W., & Mucci, L. A. (2014). Androgen receptor CAG repeat polymorphism and risk of TMPRSS2:ERG-positive prostate cancer. Cancer Epidemiol Biomarkers Prev, 23(10), 2027-2031. doi:10.1158/1055-9965.EPI-14-0020

Bhat-Nakshatri, P., Song, E. K., Collins, N. R., Uversky, V. N., Dunker, A. K., O'Malley, B. W., Geistlinger, T. R., Carroll, J. S., Brown, M., & Nakshatri, H. (2013). Interplay between estrogen receptor and AKT in estradiol-induced alternative splicing. BMC Med Genomics, 6, 21. doi:10.1186/1755-8794-6-21

Cai, C., Wang, H., He, H. H., Chen, S., He, L., Ma, F., Mucci, L., Wang, Q., Fiore, C., Sowalsky, A. G., Loda, M., Liu, X. S., Brown, M., Balk, S. P., & Yuan, X. (2013). ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer. J Clin Invest, 123(3), 1109-1122. doi:10.1172/JCI66666

Du, Z., Fei, T., Verhaak, R. G., Su, Z., Zhang, Y., Brown, M., Chen, Y., & Liu, X. S. (2013). Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nat Struct Mol Biol, 20(7), 908-913. doi:10.1038/nsmb.2591

Jeselsohn, R. M., Werner, L., Regan, M. M., Fatima, A., Gilmore, L., Collins, L. C., Beck, A. H., Bailey, S. T., He, H. H., Buchwalter, G., Brown, M., Iglehart, J. D., Richardson, A., & Come, S. E. (2013). Digital quantification of gene expression in sequential breast cancer biopsies reveals activation of an immune response. PLoS One, 8(5), e64225. doi:10.1371/journal.pone.0064225

Li, Q., Seo, J. H., Stranger, B., McKenna, A., Pe'er, I., Laframboise, T., Brown, M., Tyekucheva, S., & Freedman, M. L. (2013). Integrative eQTL-based analyses reveal the biology of breast cancer risk loci. Cell, 152(3), 633-641. doi:10.1016/j.cell.2012.12.034

McLaughlin, S. K., Olsen, S. N., Dake, B., De Raedt, T., Lim, E., Bronson, R. T., Beroukhim, R., Polyak, K., Brown, M., Kuperwasser, C., & Cichowski, K. (2013). The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. Cancer Cell, 24(3), 365-378. doi:10.1016/j.ccr.2013.08.004

Merenbakh-Lamin, K., Ben-Baruch, N., Yeheskel, A., Dvir, A., Soussan-Gutman, L., Jeselsohn, R., Yelensky, R., Brown, M., Miller, V. A., Sarid, D., Rizel, S., Klein, B., Rubinek, T., & Wolf, I. (2013). D538G mutation in estrogen receptor-alpha: A novel mechanism for acquired endocrine resistance in breast cancer. Cancer Res, 73(23), 6856-6864. doi:10.1158/0008-5472.CAN-13-1197

Ni, M., Chen, Y., Fei, T., Li, D., Lim, E., Liu, X. S., & Brown, M. (2013). Amplitude modulation of androgen signaling by c-MYC. Genes Dev, 27(7), 734-748. doi:10.1101/gad.209569.112

Pfefferle, A. D., Herschkowitz, J. I., Usary, J., Harrell, J. C., Spike, B. T., Adams, J. R., Torres-Arzayus, M. I., Brown, M., Egan, S. E., Wahl, G. M., Rosen, J. M., & Perou, C. M. (2013). Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol, 14(11), R125. doi:10.1186/gb-2013-14-11-r125

Sun, H., Qin, B., Liu, T., Wang, Q., Liu, J., Wang, J., Lin, X., Yang, Y., Taing, L., Rao, P. K., Brown, M., Zhang, Y., Long, H. W., & Liu, X. S. (2013). CistromeFinder for ChIP-seq and DNase-seq data reuse. Bioinformatics, 29(10), 1352-1354. doi:10.1093/bioinformatics/btt135

Tam, W. L., Lu, H., Buikhuisen, J., Soh, B. S., Lim, E., Reinhardt, F., Wu, Z. J., Krall, J. A., Bierie, B., Guo, W., Chen, X., Liu, X. S., Brown, M., Lim, B., & Weinberg, R. A. (2013). Protein kinase C alpha is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell, 24(3), 347-364. doi:10.1016/j.ccr.2013.08.005

He, H. H., Meyer, C. A., Chen, M. W., Jordan, V. C., Brown, M., & Liu, X. S. (2012). Differential DNase I hypersensitivity reveals factor-dependent chromatin dynamics. Genome Res, 22(6), 1015-1025. doi:10.1101/gr.133280.111

Xu, K., Wu, Z. J., Groner, A. C., He, H. H., Cai, C., Lis, R. T., Wu, X., Stack, E. C., Loda, M., Liu, T., Xu, H., Cato, L., Thornton, J. E., Gregory, R. I., Morrissey, C., Vessella, R. L., Montironi, R., Magi-Galluzzi, C., Kantoff, P. W., Balk, S. P., Liu, X. S., & Brown, M. (2012). EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science, 338(6113), 1465-1469. doi:10.1126/science.1227604

Baba, A., Ohtake, F., Okuno, Y., Yokota, K., Okada, M., Imai, Y., Ni, M., Meyer, C. A., Igarashi, K., Kanno, J., Brown, M., & Kato, S. (2011). PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B. Nat Cell Biol, 13(6), 668-675. doi:10.1038/ncb2228

Cai, C., He, H. H., Chen, S., Coleman, I., Wang, H., Fang, Z., Chen, S., Nelson, P. S., Liu, X. S., Brown, M., & Balk, S. P. (2011). Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1. Cancer Cell, 20(4), 457-471. doi:10.1016/j.ccr.2011.09.001

Fujiki, R., Hashiba, W., Sekine, H., Yokoyama, A., Chikanishi, T., Ito, S., Imai, Y., Kim, J., He, H. H., Igarashi, K., Kanno, J., Ohtake, F., Kitagawa, H., Roeder, R. G., Brown, M., & Kato, S. (2011). GlcNAcylation of histone H2B facilitates its monoubiquitination. Nature, 480(7378), 557-560. doi:10.1038/nature10656

Liu, T., Ortiz, J. A., Taing, L., Meyer, C. A., Lee, B., Zhang, Y., Shin, H., Wong, S. S., Ma, J., Lei, Y., Pape, U. J., Poidinger, M., Chen, Y., Yeung, K., Brown, M., Turpaz, Y., & Liu, X. S. (2011). Cistrome: an integrative platform for transcriptional regulation studies. Genome Biol, 12(8), R83. doi:10.1186/gb-2011-12-8-r83

Madak-Erdogan, Z., Lupien, M., Stossi, F., Brown, M., & Katzenellenbogen, B. S. (2011). Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs. Mol Cell Biol, 31(1), 226-236. doi:10.1128/MCB.00821-10

Ni, M., Chen, Y., Lim, E., Wimberly, H., Bailey, S. T., Imai, Y., Rimm, D. L., Liu, X. S., & Brown, M. (2011). Targeting androgen receptor in estrogen receptor-negative breast cancer. Cancer Cell, 20(1), 119-131. doi:10.1016/j.ccr.2011.05.026

Serandour, A. A., Avner, S., Percevault, F., Demay, F., Bizot, M., Lucchetti-Miganeh, C., Barloy-Hubler, F., Brown, M., Lupien, M., Metivier, R., Salbert, G., & Eeckhoute, J. (2011). Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers. Genome Res, 21(4), 555-565. doi:10.1101/gr.111534.110

Tang, Q., Chen, Y., Meyer, C., Geistlinger, T., Lupien, M., Wang, Q., Liu, T., Zhang, Y., Brown, M., & Liu, X. S. (2011). A comprehensive view of nuclear receptor cancer cistromes. Cancer Res, 71(22), 6940-6947. doi:10.1158/0008-5472.CAN-11-2091

Wang, C., Mayer, J. A., Mazumdar, A., Fertuck, K., Kim, H., Brown, M., & Brown, P. H. (2011). Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen receptor and the AP-1 transcription factor. Mol Endocrinol, 25(9), 1527-1538. doi:10.1210/me.2011-1037

Yang, M., Xie, W., Mostaghel, E., Nakabayashi, M., Werner, L., Sun, T., Pomerantz, M., Freedman, M., Ross, R., Regan, M., Sharifi, N., Figg, W. D., Balk, S., Brown, M., Taplin, M. E., Oh, W. K., Lee, G. S., & Kantoff, P. W. (2011). SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer. J Clin Oncol, 29(18), 2565-2573. doi:10.1200/JCO.2010.31.2405

Ahmadiyeh, N., Pomerantz, M. M., Grisanzio, C., Herman, P., Jia, L., Almendro, V., He, H. H., Brown, M., Liu, X. S., Davis, M., Caswell, J. L., Beckwith, C. A., Hills, A., Macconaill, L., Coetzee, G. A., Regan, M. M., & Freedman, M. L. (2010). 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc Natl Acad Sci U S A, 107(21), 9742-9746. doi:10.1073/pnas.0910668107

He, H. H., Meyer, C. A., Shin, H., Bailey, S. T., Wei, G., Wang, Q., Zhang, Y., Xu, K., Ni, M., Lupien, M., Mieczkowski, P., Lieb, J. D., Zhao, K., Brown, M., & Liu, X. S. (2010). Nucleosome dynamics define transcriptional enhancers. Nat Genet, 42(4), 343-347. doi:10.1038/ng.545

Lupien, M., Meyer, C. A., Bailey, S. T., Eeckhoute, J., Cook, J., Westerling, T., Zhang, X., Carroll, J. S., Rhodes, D. R., Liu, X. S., & Brown, M. (2010). Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance. Genes Dev, 24(19), 2219-2227. doi:10.1101/gad.1944810

Bhat-Nakshatri, P., Wang, G., Collins, N. R., Thomson, M. J., Geistlinger, T. R., Carroll, J. S., Brown, M., Hammond, S., Srour, E. F., Liu, Y., & Nakshatri, H. (2009). Estradiol-regulated microRNAs control estradiol response in breast cancer cells. Nucleic Acids Res, 37(14), 4850-4861. doi:10.1093/nar/gkp500

Boros, J., Donaldson, I. J., O'Donnell, A., Odrowaz, Z. A., Zeef, L., Lupien, M., Meyer, C. A., Liu, X. S., Brown, M., & Sharrocks, A. D. (2009). Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery. Genome Res, 19(11), 1963-1973. doi:10.1101/gr.093047.109

Eeckhoute, J., Lupien, M., Meyer, C. A., Verzi, M. P., Shivdasani, R. A., Liu, X. S., & Brown, M. (2009). Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers. Genome Res, 19(3), 372-380. doi:10.1101/gr.084582.108

Sun, T., Wang, Q., Balk, S., Brown, M., Lee, G. S., & Kantoff, P. (2009). The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines. Cancer Res, 69(8), 3356-3363. doi:10.1158/0008-5472.CAN-08-4112

Xia, X., Lemieux, M. E., Li, W., Carroll, J. S., Brown, M., Liu, X. S., & Kung, A. L. (2009). Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc Natl Acad Sci U S A, 106(11), 4260-4265. doi:10.1073/pnas.0810067106

Zhang, Q., Gu, J., Li, L., Liu, J., Luo, B., Cheung, H. W., Boehm, J. S., Ni, M., Geisen, C., Root, D. E., Polyak, K., Brown, M., Richardson, A. L., Hahn, W. C., Kaelin, W. G., Jr., & Bommi-Reddy, A. (2009). Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell, 16(5), 413-424. doi:10.1016/j.ccr.2009.09.029


Publications before 2009

Qianben Wang,Wei Li,Yong Zhang ,Xin Yuan, Kexin Xu, Jindan Yu, Zhong Chen, Rameen Beroukhim, Hongyun Wang, Mathieu Lupien, Tao Wu, Meredith M. Regan, Clifford A. Meyer, Jason S. Carroll, Arjun Kumar Manrai, Olli A. Jänne, Steven P. Balk, Rohit Mehra, Bo Han, Arul M. Chinnaiyan, Mark A. Rubin, Lawrence True, Michelangelo Fiorentino, Christopher Fiore, Massimo Loda, Philip W. Kantoff, X. Shirley Liu, and Myles Brown. Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer. Cell (2009) 138, 245-256. [Download PDF] [Supplemental Material] [Link to Data]

Eeckhoute J, Lupien M and Brown M. Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers. Genome Research (2009) 19: 372-380.[Download PDF] [Supplemental Material]

Krum, Susan A., Gustavo A Miranda-Carboni, Lupien M, Eeckhoute J, Carroll JS, and Brown M. Unique ERalpha Cistromes Control Cell Type-Specific Gene Regulation. Mol Endo (2008) 22(11), 2393-2406.[Download PDF]

Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W, Carroll JS, Liu XS and Brown MA. FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription. Cell (2008) 132,958-970. [Download PDF]

Krum, Susan A., Gustavo A Miranda-Carboni, Peter V. Hauschka, Jason S. Carroll, Timothy F. Lane, Leonard P.Freedmanand Myles Brown. Estrogen Protects Bone by Inducing Fas Ligand in Osteoblasts to Regulate Osteoclast Survival. The EMBO Journal (2008) 27, 535–545.[Download PDF]

Wang Q, Li W, Liu XS, Carroll JS, Janne OA, Keeton EK, Chinnaiyan AM, Pienta KJ, Brown M. A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol Cell. 2007 Aug 3;27(3):380-92 [Download PDF] [Link to Raw Data]

Eeckhoute J, Keeton EK, Lupien M, Krum SA, Carroll JS, and Brown M. Positive Cross-Regulatory Loop Ties GATA-3 to Estrogen Receptor A Expression in Breast Cancer. Cancer Res. 2007 67: (13) 6477-6483. [Download PDF]

Durand M, Kolpak A, Farrell T, Elliott NA,Shao W, Brown M, Volkert MR. The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins. BMC Cell Biol. 2007 Mar 28;8:13. [Download PDF]

Torres-Arzayus MI, Yuan J, DellaGatta JL, Lane H, Kung AL, Brown M. Targeting the AIB1 oncogene through mammalian target of rapamycin inhibition in the mammary gland. Cancer Res. 2006 Dec 1;66(23):11381-8. [Download PDF]

Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS,Keeton EK, Fertuck KC,Hall GF, Wang Q, Bekiranov S, Sementchenko V, FoxEA, Silver PA, Gingeras TR, Liu XS, Brown M. Genome-wide analysis of estrogen receptor binding sites. Nat Genet. 2006; 38:1289-1297. [Download PDF] [Link to datasets] [load data in UCSC genome browser]

Jérôme Eeckhoute, Jason S. Carroll, Timothy R. Geistlinger, Maria I. Torres-Arzayus, and Myles Brown. A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer. Genes and Development 2006; 20: 2513–2526. Download PDF.

Carroll JS and Brown M. Estrogen receptor target gene: an evolving concept. Mol Endocrinology 2006; 8: 1707-14. Download PDF.

Wang Q, Carroll JS and Brown M. Spatial and Temporal Recruitment of Androgen
Receptor and Its Coactivators Involves Chromosomal Looping and Polymerase Tracking. Molecular Cell 2005; 19: 631–642. Download PDF

Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M. Chromosome-Wide Mapping of Estrogen Receptor Binding Reveals Long-Range Regulation Requiring the Forkhead Protein FoxA1. Cell 2005; 122(1): 33-43. [Download PDF] [Link to datasets]

Keeton EK and Brown M. Cell Cycle Progression Stimulated by Tamoxifen-
Bound Estrogen Receptor- and Promoter-Specific Effects in Breast Cancer Cells Deficient in N-CoR and SMRT. Molecular Endocrinology 2005; 19(6):1543–1554. Download PDF

Torres-Arzayus M., Font de Mora J., Yuan J., Vazquez F., Bronson R., Rue M., Sellers W., Brown M. High Tumor Incidence and Activation of the PI3K/AKT Pathway in Transgenic Mice define AIB1 as an Oncogene. Cancer Cell 2004, 6: 263-274. Download PDF

Shao W, Keeton EK, McDonnell DP, Brown M. Coactivator AIB1 links estrogen receptor transcriptional activity and stability. PNAS. 2004; 101(32):11599-604. Download PDF

Shao W, Brown M. Advances in Estrogen receptor Biology: Prospects for improvements in targeted Breast Cancer Therapy. Review. Breast Cancer Res. 2004; 6(1): 39-52. Download PDF

Hestermann E., Brown M. Agonist and chemopreventive ligands induce differential trancriptional cofactor recruitment by aryl hardrocarbon receptor. Mol. Cell Biol. 2003; 23(21):7920-7925. Download PDF

Shang Y, Brown M. Molecular determinants for the tissue specificity of SERMs. Science 2002; 295: 2465-2468. Download PDF

Shang Y, Myers M, Brown M. Formation of the androgen receptor transcription complex. Molecular Cell 2002; 9: 601-610. Download PDF. Erratum .

Shao W, Halachmi S, Brown M. ERAP140, a conserved tissue-specific receptor coactivator. Mol. Cell Biol. 2002; 22(10): 3358-3372. Download PDF

DiRenzo J, Signoretti S, Nakamura N,Rivera-Gonzalez R, Sellers WR, Loda M, Brown M. Growth factor requirement and basal phenotype of immortalized mammary epithelial cells. Cancer Res. 2002; 62:89-98. Download PDF

Yahata T, Shao W, Endoh H, Hur J, Coser KR, Sun H, Ueda Y, Kato S, Isselbacher KJ, Brown M, Shioda T. Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein. Genes Dev. 2001; 15:2598-2612. Download PDF

Rebbeck TR, Wang Y, Kantoff PW, Krithivas K, Neuhausen S, Godwin AK, Daly MB, Narod SA, Brunet J-S, Vesprini D, Garber JE, Lynch HT, Weber BL, Brown M. Modification of BRCA-1 and BRCA-2 associated breast cancer risk by AIB1 genotype and reproductive history Cancer Res 2001; 61:5420-5424. download pdf

Jones GB, Hynd G, Wright JM, Purohit A,Plourde II GW, Huber RS, Matthews JE, Li A, Kilgore MW, Bubley GJ, Yancisin M, Brown M. Target directed enediynes J. Org. Chem. 2001; 66(11): 3688-3695. download pdf

Planas-Silva MD, Shang Y, Donaher JL, Brown M, Weinberg RA AIB1 enhances estrogen dependent induction of Cyclin D1 promoter. Cancer Res. 2001; 61(10): 3858-62. download pdf

Shang Y, Hu X, Lazar MA, DiRenzo, J, Brown M. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription.Cell 2000 Dec; 103:843-852. download pdf.

DiRenzo, J, Shang, Y, Phalen, M, Sif, S, Myers, M, Kingston, R, Brown, M. BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. Mol Cell Biol 2000 Oct; 20(20):7541-7549 download pdf.

Carroll, RS, Brown, M, Zhang, J, DiRenzo, J, Font de Mora, J, Black, PM. Expression of a subset of steroid receptor cofactors is associated with progesterone receptor expression in meningiomas. Clin Cancer Res 2000 Sep; 6:3570-3575 PubMed abstract.

Haiman CA, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Speizer FE, Brown M, Hunter DJ. A polymorphic repeat in AIB1 does not alter breast cancer risk. Breast Cancer Res 2000 Jun19; 2:378-385. download pdf.

Font de Mora, J, Brown, M. AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Mol Cell Biol 2000 Jul 15;20(14):5041-5047 download pdf.

Jones GB, Wright JM, Hynd G, Wyatt JK, Yancisin M, Brown M. Library screening allows rapid identification of bioactive enediynes. Org Lett 2000 Jun 29;2(13):1863-1866 download pdf.

Poelzl G, Kasai Y, Mochizuki N, Shaul PW, Brown M, Mendelsohn ME. Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2836-9 download pdf.

Platz EA, Giovannucci E, Brown M, Cieluch C, Shepard TF, Stampfer MJ, Kantoff PW. Amplified in Breast Cancer-1Gultamine Repeat and Prostate Cancer Risk. The Prostate Journal 2000, 2(1): 27-32.

Krithivas K, Yurgalevitch S, Mohr B, Wilcox C, Batter S, Brown M, Longcope C, McKinlay J, Kantoff PW. Evidence that the CAG Repeat in the androgen receptor gene is associated with the age related decline in serum androgen levels in men. J of Endo 1999; 162: 137-142 download pdf.

Rebbeck TR, Kantoff PW, Krithivas K, Blackwood MA, GodWin AK, Daly MB, Narod Sa, Garber JE, Lynch HT, Weber BL, Brown M. Modification of BRCA1-associated breast cnacer penetrance by the polymorphic androgen receptor CAG repeat. Am J Hum Genet 1999, 64(5): 1371-7 download pdf.

Hanstein B, Liu H, Yancisin M, DiRenzo J, Brown M. Functional analysis of a novel estrogen receptor beta isoform. Mol Endocrinol 1999 Jan; 13(1): 129-37 download pdf.

Shim WS, DiRenzo J, DeCaprio JA, Santen RJ, Brown M, Jeng MH. Segregation of steroid receptor coactivator-1 from steroid receptors in mammary epithelium. Proc Natl Acad Sci 1999 Jan 5; 96(1): 208-213 download pdf.

Febbo PG, Kantoff PW, Giovannucci E, Brown M, Chang G, Hennekens CH, Stampfer M. Debrisoquine hydroxylase (CYP2D6) and prostate cancer. Cancer Epidemiol biomarkers Preven 1998; 7(12): 1075-8 PubMed abstract.

Seol W, Hanstein B, Brown M, Moore DD. Inhibition of estrogen receptor action by the orphan receptor SHP. Mol Endocrinol 1998 Oct; 12(10): 1551-7 PubMed abstract.

Platz E, Giovannucci E, Dahl D, Krithivas K, Brown M, Hennekens C, Stampfer M, Kantoff PW. The GGn repeat in the androgen receptor and prostate cancer risk. Cancer Epidemiol Biomarkers Preven 1998; 7(5): 379-384 PubMed abstract.

Halachmi S. Charaterization and cloning of an estrogen receptor coaxtivator. Ph.D. Thesis, Harvard University, 1997; 126 pages. download pdf.

Neuman E, Ladha MH, Lin N, Upton TM, Miller SJ, DiRenzo J, Pestell RG, Hinds PW, Dowdy SF, Brown M, Ewen ME. Cyclin D1 Stimulation of estrogen receptor transcription independent of cdk4 activation. Mol Cell Biol 1997; 17(9): 5338-5347 download pdf.

Treilleux I, Peloux N, Brown M, Seargeant A. Human estrogen receptor gene promoter P1: estradiol independent activity and estradiol inducibility in ER+ and ER- cells. Mol Endocrinol 1997; 11(9): 1319-1331.

Kantoff PW, Febbo PG, Giovannucci E, Krithivas K, Dahl DM, Chang G, Hennekens CH, Brown M, Stampfer MJ. A polymorphism of the 5 alpha-reductase gene and its association with prostate cancer: a case-control analysis. Cancer Epidemiol Biomarkers Preven 1997; 6(3); 189-192 PubMed abstract.

Tang Z, Treilleux I, Brown M. A transcriptional enhancer required for the differential expression of the human estrogen receptor in breast cancer. Mol Cell Biol 1997; 17(3): 1274-1280 download pdf.

Giovannucci E, Stampfer MJ, Krithivas K, Brown M, Brufsky A, Talcott J, Hennekens Ch, Kantoff PW. The CAG repeat within the androgen receptor and prostate cancer progression. Proc Natl Acad Sci 1997; 94: 3320-3323 PubMed abstract.

Hanstein B, Eckner R, DiRenzo J, Halachmi S, Liu H, Searacy B, Brown M. p300 is a component of an estrogen receptor co-activator complex. Proc Natl Acad Sci 1996; 93(21): 11540-5 download pdf.

Scully R, Ganesan S, Brown M, DeCaprio JA, Cannistra SA, Feunteun J, Schnitt S, Livingston DM. Location of BRCA1 in human breast and ovarian cancer cells. Science 1996; 272: 123-5 PubMed abstract.

Kurokawa R, Söderström M, Hörlein A, Halachmi S, Brown M, Rosenfeld MG, Glass CK. Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature 1995; 377: 451-4 PubMed abstract.

Yu K, Bayona W, Kallen CB, Harding HP, Ravera CP, McMahon G, Brown M, Lazar MA. Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem 1995; 270(41): 23975-83 download pdf.

Halachmi S, Marden E, Martin G, MacKay H, Abbondanza C, Brown M. Estrogen receptor associated proteins: possible mediators of hormone-induced transcription. Science 1994; 264: 1455-8 PubMed abstract.

Segars JH, Marks MS, Hirschfeld S, Driggers PH, Martinez E, Grippo JF, Brown M, Wahli W, Ozato K. Inhibition of estrogen-responsive gene activation by the retinoid X receptor B: evidence for multiple inhibitory pathways. Mol Cell Biol 1993; 13: 2258-68 (author correction, vol. 15, p 3840) PubMed abstract.



Reviews

Krum SA and Brown M. Unraveling estrogen action in osteoporosis. Cell Cycle 2008, 7:10, 1348-52. Download PDF.

Carroll JS and Brown M. Estrogen receptor target gene: an evolving concept. Mol Endocrinology 2006; 8: 1707-14. Download PDF.

Shao W, Brown M. Advances in Estrogen receptor Biology: Prospects for improvements in targeted Breast Cancer Therapy. Review. Breast Cancer Res. 2004; 6(1): 39-52. Download PDF

Miner JN, Brown M. Glucocorticoid Acion. In: Austen S, Burakoff SJ, et al., eds. Therapeutic Immunology, 2nd edition, Blackwell Science Inc., 2000.

Kantoff P, Giovannucci E, Brown M. The androgen receptor CAG repeat polymorphism and its relationship to prostate cancer. Biochemica et Biophysica Act 1378 (1998) C1- C5.

Brown M. Estrogen Receptor Molecular Biology. In: Henderson IC, Shapiro CL, eds. Hematology/Oncology Clinics of North America, W.B. Saunders Co., 1994; Vol 8, pp101—12

Glass CK, Brown MA. Molecular Mechanisms of Estrogen and Thyroid Hormone Action. In: Noda, M. ed. Molecular and Cellular Biology of Bone, Academic Press 1993: 257—85.

[ back to top ]