The Walensky Lab: Stapled BCL-2 Peptides
The Walensky laboratory focuses on the chemical biology of deregulated apoptotic and transcriptional pathways in cancer. Our goal is to develop an arsenal of new compounds-a “chemical toolbox”-to investigate and block protein interactions that cause cancer. To achieve these objectives, we take a multidisciplinary approach that employs synthetic chemistry techniques, structural biology analyses, and biochemical, cellular, and mouse modeling experiments to systematically dissect the pathologic signaling pathways of interest.
Recent News
Congrats Grads!
Monday, 03 June 2013
Congratulations to Walensky Lab PhD Graduates: Nicole Cohen (HMS BBS), Amanda Lee (HMS BBS), Elizaveta Leshchiner (HU Chemistry)
Welcome William Marrero-Ortiz
Friday, 31 May 2013
The Walensky lab welcomes William Marrero-Ortiz – HMS Summer Honors Undergraduate Research Program.
Welcome Daniel Weinstein
Monday, 27 May 2013
The Walensky lab welcomes Daniel Weinstein – Summer Fellow in the lab’s Expose-Inspire-Launch Program.
Direct Activation of Full-Length Proapoptotic BAK
Tuesday, 12 February 2013
New paper: "Direct Activation of Full-Length Proapoptotic BAK" by Leschiner et al., appears in PNAS. Read the paper here.
Seeking Your Talent!
Friday, 01 February 2013
We are currently seeking candidates to fill the following positions in our laboratory:
1. Postdoctoral Fellows: The Walensky laboratory is seeking highly accomplished PhD graduates applying for postdoctoral fellowship training in cancer chemical biology.  We are particularly interested in candidates with deep expertise in structural biology, proteomics, molecular and cellular biology, or mouse modeling.
2. Science Writer: This position is geared to experienced basic science writers or editors who are interested in part-time or full-time work for a dynamic multidisciplinary laboratory.  Work tasks would include the design, preparation, and editing of manuscripts, grants, and other scientific documents. PhD level experience in science or english, and deep experience in science writing as a basic scientist or journal editor is required.
3. Laboratory Operations Manager: The Walensky laboratory is seeking a PhD-level scientist or MBA-trained manager to work hand-in-hand with Dr. Walensky to manage a diversity of laboratory research programs and initiatives.  Experience with personnel management, database/software development, scientific project leadership, computational biology, and business administration are key criteria for this position.
Applicants should submit a CV, career goals statement, and three letters of reference by email to Sharon Gittens ( This e-mail address is being protected from spam bots, you need JavaScript enabled to view it )   
How can we help?
Friday, 01 February 2013
Our laboratory specializes in the design, synthesis, and application of stapled alpha-helical peptides for biomedical research. We are pleased to participate in academic collaborations by designing and generating stapled peptides for your research needs.  Our goal is to remain fully engaged with our collaborators to provide ongoing input on experimental design, data analysis, and project development. Charges to the investigator are for synthesis costs only and approximate core facility fees for standard peptide synthesis. Submit your project proposals by email to Greg Bird ( This e-mail address is being protected from spam bots, you need JavaScript enabled to view it )