Publications

Original Reports

2008
Xu C, Gagnon E, Call ME, Schnell JR, Schwieters CD, Carmen CV, Chou JJ, Wucherpfennig KW, Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. Cell. 2008 Nov 14;135(4):594-6.. (Pubmed)

McLaughlin KA, Wucherpfennig KW B cells and autoantibodies in the pathogenesis of multiplesclerosis and related inflammatory demyelinating diseases. Adv Immunol. 2008;98:121-49. Review. (Pubmed)

Bowen DG, Shoukry NH, Grakoui A, Fuller MJ, Cawthon AG, Dong C, Hasselschwert DL, Brasky KM, Freeman GJ, Seth NP, Wucherpfennig KW, Houghton M, Walker CM. Variable patterns of programmed death-1 (PD-1) expression on fully functional memory T cells following spontaneous resolution of hepatitis C virus infection. J Virol. 2008. (Pubmed)

Verginis P, McLaughlin KA, Wucherpfennig KW, von Boehmer H, Apostolou I. Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Proc Natl Acad Sci U S A. 2008. (Pubmed)

2007
Nose H, Kubota R, Seth NP, Goon PK, Tanaka Y, Izumo S, Usuku K, Ohara Y, Wucherpfennig KW, Bangham CR, Osame M, Saito M. Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide. J Infect Dis. 2007. (Pubmed)

Call ME, Wucherpfennig KW. Common themes in the assembly and architecture of activating immune receptors. Nat Rev Immunol. 2007. (Pubmed)

Wucherpfennig KW, Allen PM, Celada F, Cohen IR, De Boer R, Garcia KC, Goldstein B, Greenspan R, Hafler D, Hodgkin P, Huseby ES, Krakauer DC, Nemazee D, Perelson AS, Pinilla C, Strong RK, Sercarz EE. Polyspecificity of T cell and B cell receptor recognition. Semin Immunol. 2007. (Pubmed)

Grotenbreg GM, Nicholson MJ, Fowler KD, Wilbuer K, Octavio L, Yang M, Chakraborty AK, Ploegh HL, Wucherpfennig KW. Empty class II MHC created by peptide photolysis establishes role of DM in peptide association. J Biol Chem 2007. (Pubmed)

Lu L, Ikizawa K, Hu D, Werneck MB, Wucherpfennig KW, Cantor. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity. 2007 May;26(5):593-604. (Pubmed)

Garibyan L, Lobito AA, Siegel RM, Call ME, Wucherpfennig KW, Geha RS. Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). J Clin Invest. 2007 Jun;117(6):1550-7. (Pubmed)

Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, Backstrom BT, Sobel RA, Wucherpfennig KW, Strom TB, Oukka M, Kuchroo VK. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med. 2007; 13:423-31. (Pubmed)

Moza B, Varma AK, Buonpane RA, Zhu P, Herfst CA, Nicholson MJ, Wilbuer AK, Seth NP, Wucherpfennig KW, McCormick JK, Kranz DM, Sundberg EJ. Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1. EMBO J. 2007; 26(4):1187-97. (Pubmed)

O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafler DA, Wucherpfennig KW. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nature Medicine, 2007;13:211-7. (Pubmed)

2006
Call ME, Schnell JR, Xu, Chenqi, Lutz, RA, Chou, JJ, Wucherpfennig KW. The structure of the zz transmembrane dimer reveals features essential for its assembly with the t cell receptor. Cell, 2006; 127, 355-68. (Pubmed)

Xu C, Call ME, Wucherpfennig KW. A membrane-proximal tetracysteine motif contributes to assembly of CD3delta epsilon and CD3gamma epsilon dimers with the T cell receptor. JBC, 2006; Oct 5. (Pubmed)

Ulsenheimer A, Lucas M, Seth NP, Tilman Gerlach J, Gruener NH, Loughry A, Pape GR, Wucherpfenng KW, Diepolder HM, Klenerman P.Transient immunological control during acute hepatitis C virus infection: ex vivo analysis of helper T-cell responses. J Viral Hepat, 2006 10:708-14. (Pubmed)

Feng J, Call ME, Wucherpfennig KW. The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site.
PLoS Biol. 2006; 4(5): e142. (Pubmed)

Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW.  Small molecules that enhance the catalytic efficiency of HLA-DM. J. Immunol. 2006; 176: 4208-20. (Pubmed)

2005
O’Connor KC, Appel H, Bregoli L, Call ME, Catz I, Chan JA, Moore NH, Warren KG, Wong SJ, Hafler DA, Wucherpfennig KW. Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein.  J. Immunol. 2005, 175: 1974-82. (Pubmed)

Reddy J, Waldner H, Zhang X, Illes Z, Wucherpfennig KW, Sobel RA, Kuchroo VK. CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis. J. Immunol. 2005; 175: 5591-5. (Pubmed)

Seth N, Kaufmann D, Lahey T, Rosenberg ES, Wucherpfennig KW
Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication. J. Immunol. 2005; 175: 6948-58. (Pubmed)

Garrity D, Call ME, Feng J, Wucherpfennig KW. The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure.
Proc Natl Acad Sci USA. 2005 May 24;102(21):7641-6 (PDF)

Feng J, Garrity D, Call ME, Moffett H, Wucherpfennig KW
Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors.
Immunity. 2005 Apr;22(4):427-38 (PubMed)

Hahn M, Nicholson MJ, Pyrdol J, Wucherpfennig KW.
Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor.
Nat Immunol. 2005 May;6(5):490-6. (PDF)

2004
Reddy J, Illes Z, Zhang X, Encinas J, Nicholson L, Sobel RA, Wucherpfennig KW, Kuchroo VK
Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis
Proc. Nat. Acad. Sci (USA) 2004 Oct 26;101(43):15434-9. (PDF)

Tian C, Bagley J, Cretin N, Seth N, Wucherpfennig KW, Iacomini J
Prevention of type 1 diabetes by gene therapy
J Clin Invest. 2004 Oct;114(7):969-78. (PubMed)

Appel H, Kuon W, Kuhne M, Hülsmeyer M, Kollnberger S, Kuhlmann S, Weiss E, Zeiz M, Wucherpfennig KW, Bowness P, Sieper J
The solvent-inaccessible Cys-67 residue of HLA-B27 contributes to T cell recognition of HLA-B27/peptide complexes
J Immunol. 2004 Dec 1;173(11):6564-73. (PubMed)

Haining WN, Evans J, Seth NP, Callaway D, Wucherpfennig KW, Nadler LM, Guinan EC
Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation
British Journal of Haematology. 2004 Nov;127(3):322-5. (PDF)

Ferlin WG, Mougneau E, Hugues S, Appel H, Jang MH, Cazareth J, Beaudoin L, Schricke C, Lehuen A, Wucherpfennig KW, Glaichenhaus N
Frontline: Self-peptides that bind with low affinity to the diabetes-associated I-Ag7 molecule readily induce T cell tolerance in non-obese diabetic mice
Eur. J. Immunol. 2004; 10: 2656. (PubMed)

Call ME, Wucherpfennig KW
Stoichiometry of the T cell receptor-CD3 complex and key intermediates assembled in the ER
EMBO Journal 2004;12: 2348-57 (PDF)

Havari, E, Lennon-Dumenil AM, Klin L, Neely D, Taylor JA, McInerney MF, Wucherpfennig KW, Lipes MA
Expression of the B7.1 costimulatory molecule on pancreatic beta cells abrogates the requirement for CD4 T cells in the development of type 1 diabetes
J. Immunol. 2004; 173: 787-96. (PubMed)

Mycko MP, Waldner H, Anderson DE, Boucier KD, Wucherpfennig KW, Kuchoroo VK, Hafler D
Cross-reactive TCR responses to self antigens presented by different MHC class II molecules
J. Immunol. 2004; 173: 1689-98. (PubMed)

Panoutsakopoulou V, Huster KM, McCarty N, Feinberg E, Wang R, Wucherpfennig KW, Cantor H
Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes
J. Clin. Invest. 2004; 113: 1218-24. (PubMed)

Taylor JA, Havari E, McInerney MF, Bronson R, Wucherpfennig KW, Lipes MA.
A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8
J. Immunol. 2004; 172: 2651-8 (PubMed)

2003
Berretta F, Butler RH, Diaz G, Sanarico N, Arroyo J, Fraziano M, Aichinger G, Wucherpfennig KW, Colizzi V, Saltini C, Amicosante M
Detailed analysis of the effects of Glu/Lys b69 human leukocyte antigen-DP polymorphism on peptide-binding specificity
Tissue Antigens 2003; 62: 459-71. (PubMed)

Maecker B, Sherr DH, Vonderheide RH, Von Bergwelt-Baildon MS, Hirano N, Anderson KS, Xia Z, Butler MO, Wucherpfennig KW, O'Hara C, Cole G, Kwak SS, Ramstedt U, Tomlinson AJ, Chicz RM, Nadler LM, Schultze JL
The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells
Blood 2003; 102: 3287-94.©American Society of Hematology.(PDF)

Jang M-H, Seth N, Wucherpfennig KW
Ex vivo analysis of thymic CD4 T cells in NOD mice with tetramers generated from I-Ag7/class II-associated invariant chain peptide precursors
J. Immunol., 2003; 171: 4175-86.(PubMed)

Day CL, Seth N, Lucas M, Appel H, Gauthier L, Lauer GM, Robbins GK, Szczepiorkowski ZM, Casson DR, Chung RT, Bell S, Harcourt G, Walker BD, Klenerman P, Wucherpfennig KW
Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers
J. Clin. Invest., 2003; 112: 831-42. (PubMed)

O'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW, Hafler DA
Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions
J. Neuroimmunol., 2003; 136: 140-8. (PubMed)

Reddy J, Bettelli E, Nicholson L, Waldner H, Jang MH, Wucherpfennig KW, Kuchroo VK
Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers
J. Immunol., 2003; 170: 870-7. (PubMed)

2002
Call ME, Pyrdol J, Wiedmann M, Wucherpfennig KW
The organizing principle in the formation of the T cell receptor-CD3 complex
Cell, 2002; 111: 967-79. (PubMed)

Belmares MP, Busch R, Wucherpfennig KW, McConnell HM, Mellins ED
Structural factors contributing to DM susceptibility of MHC class II/peptide complexes
J. Immunol., 2002; 169: 5109-17. (PubMed)

Lang HL, Jacobsen H, Ikemizu S, Andersson C, Harlos K, Madsen L, Hjorth P, Sondergaard L, Svejgaard A, Wucherpfennig KW, Stuart DI, Bell JI, Jones EY, Fugger L.
A functional and structural basis for TCR cross-reactivity in multiple sclerosis
Nature Immunology 2002; 3: 940-3. (PDF)

von Bergwelt-Baildon MS, Vonderheide RH, Maecker B, Hirano N, Anderson KS, Butler MO, Xia Z, Zeng WY, Wucherpfennig KW, Nadler LM, Schultze JL
Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen presenting cells: Potential for clinical application
Blood, 2002; 99: 3319-25.© American Society of Hematology (PDF)

2001
Vonderheide RH, Schultze JL, Anderson KS, Maecker B, Butler MO, Xia Z, Kuroda MJ, von Bergwelt-Baildon MS, Bedor MM, Hoar KM, Schnipper DR, Brooks MW, Letvin NL, Stephans KF, Wucherpfennig KW, Hahn WC, Nadler LM
Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals
Cancer Res., 2001; 61: 8366-70. (PubMed)

Bourcier KD, Lim D.G, Ding YH, Smith KJ, Wucherpfennig K, Hafler, DA
Conserved CDR3 regions in T-cell receptor (TCR) CD8+ T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: Relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure
J. Virol. 2001; 75: 9836-43. (PDF)

Panoutsakopoulou V, Sanchirico ME, Huster KM, Jansson M, Granucci F, Shim DJ, Wucherpfennig KW, Cantor H
Analysis of the relationship between viral infection and autoimmune disease
Immunity, 2001; 15: 137-47. (PubMed)

Lee KH, Wucherpfennig KW, Wiley DC
Structure of a human insulin peptide/HLA-DQ8 complex and susceptibility to type 1 diabetes
Nature Immunology, 2001, 2: 501-7. (PDF)

Appel H, Seth N, Gauthier L, Wucherpfennig KW
Anergy Induction by Dimeric TCR Ligands
J. Immunol., 2001; 166: 5279-85. (PubMed)

2000
Malherbe L, Filippi C, Julia V, Foucras G, Moro M, Appel H, Wucherpfennig KW, Guéry J-C, Glaichenhaus N
Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major
Immunity 2000; 13: 771-82. (PubMed)

Yu B, Gauthier L, Hausmann DHF, Wucherpfennig KW
Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes
Eur. J. Immunol., 2000; 30: 2497-2506. (PubMed)

Krogsgaard M, Wucherpfennig KW, Canella B, Hansen BE, Svejgaard A, Pyrdol J, Ditzel H, Raine C, Engberg J, Fugger
Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the HLA-DR2-MBP 85-99 complex
J. Exp. Med. 2000; 191: 1395-1412.© Rockefeller Univeristy Press (PDF)

Appel H, Gauthier L, Pyrdol J, Wucherpfennig KW
Kinetics of T-cell receptor binding by bivalent HLA-DR/peptide complexes that activate antigen-specific human T-cells
J. Biol. Chem. 2000; 275: 312-21. (PubMed)

1999
Madsen LS, Andersson EC, Jansson L, Krogsgaard M, Andersen CB, Engberg J, Strominger JL, Svejgaard A, Hjorth JP, Holmdahl R, Wucherpfennig KW, Fugger L.
A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor
Nature Genetics, 1999; 23: 343-7. (PDF)

Hausmann DHF, Yu B, Hausmann S, Wucherpfennig KW
pH-dependent peptide binding properties of the type I diabetes associated I-Ag7 molecule: Rapid release of CLIP at an endosomal pH
J. Exp. Med. 1999; 189: 1723-33 © Rockefeller University Press. (PDF)

Hausmann S, Biddison WE, Smith KJ, Ding Y-H, Garboczi DN, Utz U, Wiley DC, Wucherpfennig KW
Peptide recognition by two HLA-A2/Tax(11-19) specific T-cell clones in relationship to their MHC/peptide/TCR crystal structures
J. Immunol. 1999; 162: 5389-97.(PubMed)

Fridkis-Hareli M, Neveu JM, Robinson RA, Lane WS, Gauthier L, Wucherpfennig KW, Sela M, Strominger JL
Binding motifs of copolymer 1 to multiple sclerosis- and rheumatoid arthritis-associated HLA-DR molecules
J. Immunol. 1999; 162: 4697-4704. (PubMed)

Hausmann S, Martin M, Gauthier L, Wucherpfennig KW
Structural features of autoreactive T-cell receptors that determine the degree of degeneracy in peptide recognition
J. Immunol. 1999; 162: 338-44. (PubMed)

1998
Ufret-Vincenty RL, Quigley L, Tresser N, Pak SH, Gado A, Hausmann S, Wucherpfennig KW, Brocke S
In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalitis
J. Exp. Med. 1998; 188: 1725-38.© Rockefeller University Press (PDF)

Smith KJ, Pyrdol J, Gauthier L, Wiley DC, Wucherpfennig KW
Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein
J. Exp. Med. 1998; 188: 1511-20 © Rockefeller University Press. (PDF)

Gauthier L, Smith KJ, Pyrdol J, Kalandadze A, Strominger JL, Wiley DC, Wucherpfennig KW
Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic protein
Proc. Nat. Acad. Sci. (USA) 1998; 95: 11828-33. (PDF)

Eble JA, Wucherpfennig KW, Gauthier L, Dersch P, Krukonis E, Isberg RR, Hemler ME
Recombinant soluble human alpha-3 beta-1 integrin: Purification, processing, regulation and specific binding to laminin-5 and invasin in a mutually exclusive manner
Biochem. 1998; 37: 10945-55. (PubMed)

Liedtke W, Cannella B, Mazzaccaro RJ, Clements JM, Miller KM, Wucherpfennig KW, Gearing AJ, Raine CS
Effective treatment of models of multiple sclerosis by matrix metalloprotease inhibitors
Ann. Neurol. 1998; 44: 35-46. (PubMed)

1997
Warren K, Catz I, Wucherpfennig KW
Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P85VHFFKNIVTP96 in chronic progressive multiple sclerosis
J. Neurol. Sci. 1997; 152: 31-38. (PubMed)

Wucherpfennig KW, Catz I, Hausmann S, Strominger JL, Steinman L, Warren K
Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients: Identity of key contact residues in the B-cell and T-cell epitopes
J. Clin Invest. 1997; 100: 1114-22. (PubMed)

1996
Kalandadze A, Galleno M, Foncerrada L, Strominger JL, Wucherpfennig KW
Expression of recombinant HLA-DR2 molecules: Replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the assembly and secretion of soluble DR alpha beta heterodimers
J. Biol. Chem. 1996; 271: 20156-62. (PubMed)

1995
Wucherpfennig KW, Yu B, Bhol K, Monos D, Argyris E, Karr RW, Ahmed AR, Strominger JL
Structural basis of MHC-linked susceptibility to autoimmunity: Charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris
Proc. Nat. Acad. Sci (USA) 1995; 92: 11935-9. (PDF)

Wucherpfennig KW, Hafler DA, Strominger JL
Structure of human T cell receptors specific for an immunodominant myelin basic protein peptide and HLA-DR2: Positioning of T cell receptors on HLA-DR2/peptide complexes
Proc. Nat. Acad. Sci (USA) 1995; 92: 8896-8900. (PDF)

Wucherpfennig KW, Strominger JL
Molecular mimicry in T cell mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
Cell 1995; 80: 695-705. (PubMed)

1994
Chung S, Wucherpfennig KW, Friedman S, Hafler DA, Strominger JL
Functional three-domain single-chain T-cell receptors
Proc. Nat. Acad. Sci (USA) 1994; 91: 12654-8. (PDF)

Wucherpfennig KW, Zhang J, Witek C, Matsui M, Modabber Y, Ota K, Hafler DA
Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide
J. Immunol. 1994; 152: 5581-92. (PubMed)

Wucherpfennig KW, Sette A, Southwood S, Oseroff C, Matsui M, Strominger JL, Hafler DA
Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones
J. Exp. Med. 1994; 179: 279-90. © Rockefeller University Press. (PDF)

1993
Wucherpfennig KW, Liao YJ, Prendergast M, Prendergast J, Hafler DA, Strominger JL
Human fetal liver gamma delta T cells predominantly use unusual rearrangements of the TCR delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma delta T cells
J. Exp. Med. 1993; 177: 425-32. (PDF)

1992
Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner LM, Hafler DA
T cell receptor V-alpha-V-beta repertoire and cytokine gene expression in active multiple sclerosis lesions
J. Exp. Med. 1992; 175: 993-1002. (PDF)

Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner LM, Hafler DA
gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions
Proc. Nat. Acad. Sci (USA) 1992; 89: 4588-92. (PDF)

Hollsberg P, Wucherpfennig KW, Lopez VC, Bierer BE, Hafler DA
Characterization of HTLV-I in vivo infected T cell clones: IL-2 independent growth of nontransformed T cells
J. Immunol. 1992; 148: 3256-63. (PubMed)

Wucherpfennig KW, Höllsberg P, Richardson JH, Benjamin D, Hafler DA
T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones
Proc. Nat. Acad. Sci (USA) 1992; 89: 2110-4. (PDF)

1991
Balk SP, Ebert EC, Blumenthal RL, McDermott FV, Wucherpfennig KW, Landau SB, Blumberg RS
Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes
Science 1991; 253: 1411-5. (PubMed)

Lee SJ, Wucherpfennig KW, Brod SA, Benjamin D, Weiner HL, Hafler DA
Common T cell receptor V-beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis
Ann. Neurol. 1991; 29: 33-40. (PubMed)

1990
Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL, Hafler DA
Shared human T cell receptor V-beta usage to immunodominant regions of myelin basic protein
Science 1990; 248: 1016-9. (PubMed)

1989
Richardson J, Wucherpfennig KW, Endo N, Rudge P, Dagleish AD, Hafler DA
PCR analysis of DNA from multiple sclerosis patients for the presence of HTLV-I
Science 1989; 246: 821-4.

Selected Reviews, Chapters, and Editorials

Call ME, Wucherpfennig KW
The T cell receptor: Critical role of the membrane environment in receptor assembly and function
Annual Review of Immunol. 2005;23:101-25 (PDF)

Wucherpfennig KW
T cell receptor crossreactivity as a general property of T cell recognition
Mol. Immunol. 2004; 40: 1009-17. (PubMed)

Wucherpfennig KW
Insights into autoimmunity gained from structural analysis of MHC-peptide complexes
Curr. Opinion Immunol. 2001; 13: 650-6. (PubMed)

Wucherpfennig KW
Mechanisms for the induction of autoimmunity by infectious agents
J. Clin. Invest. 2001; 108: 1097-1104. (PubMed)

Wucherpfennig KW
Structural basis of molecular mimicry
J. Autoimm. 2001; 16: 293-302. (PubMed)