Articles of Interest

Reviews:

Call ME, Wucherpfennig KW
Common themes in the assembly and architecture of activating immune receptors
Nat Rev Immunol. 2007; 7:841-50. (Pubmed)

Call ME, Wucherpfennig KW
The T cell receptor: Critical role of the membrane environment in receptor assembly and function
Annual Review of Immunol. 2005;23:101-25. (PDF)

Wucherpfennig KW
T cell receptor crossreactivity as a general property of T cell recognition
Mol. Immunol. 2004; 40: 1009-17. (PubMed)

Wucherpfennig KW
Insights into autoimmunity gained from structural analysis of MHC-peptide complexes
Curr. Opinion Immunol. 2001; 13: 650-6. (PubMed)

Original Reports:

Xu C, Gagnon E, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ, Wucherpfennig KW
Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif.
Cell 2008 Nov; 14;135(4):594-6. (Pubmed)

O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafler DA, Wucherpfennig KW.
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nature Medicine, 2007;13:211-7. (Pubmed)

Call ME, Schnell JR, Xu, Chenqi, Lutz, RA, Chou, JJ, Wucherpfennig KW. The structure of the zz transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell, 2006; 127, 355-368. (Pubmed)

Hahn M, Nicholson MJ, Pyrdol J, Wucherpfennig KW.
Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor.
Nat. Immunology 2005 May;6(5):490-6 (PDF)

Feng J, Garrity D, Call ME, Moffett H, Wucherpfennig KW
Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors.
Immunity. 2005 Apr;22(4):427-38 (PubMed)

Day CL, Seth N, Lucas M, Appel H, Gauthier L, Lauer GM, Robbins GK, Szczepiorkowski ZM, Casson DR, Chung RT, Bell S, Harcourt G, Walker BD, Klenerman P, Wucherpfennig KW
Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers
J. Clin. Invest., 2003; 112: 831-42. (PubMed)

Call ME, Pyrdol J, Wiedmann M, Wucherpfennig KW
The organizing principle in the formation of the T cell receptor-CD3 complex
Cell, 2002; 111: 967-79. (PubMed)

Smith KJ, Pyrdol J, Gauthier L, Wiley DC, Wucherpfennig KW
Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein
J. Exp. Med. 1998; 188: 1511-20. Rockefeller University Press. (PDF)

Wucherpfennig KW, Strominger JL
Molecular mimicry in T cell mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
Cell 1995; 80: 695-705. (PubMed)