Key Publications:

Chen Y, Zeng X, Huang X, Serag S, Woolf CJ and Spiegelman BM. Crosstalk between Kcnk3-mediated ion current and adrenergic signaling regulates adipose thermogenesis and obesity. Cell 2017; 171(4):836-848. 

Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM. Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metab. 2017; 26(4):660-671.

Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP and Spiegelman BM. Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature 2016; 532(7597):112-116.

Zeng, X, Jedrychowski MP, Chen Y, Serag S, Lavery GG, Gygi SP, Spiegelman BM. Lysine-Specific Demethylase 1 Promotes Brown Adipose Tissue Thermogenesis via Repressing Glucocorticoid Activation. Genes & Dev. 2016; 30(16):1822-1836.

Long JZ, Svensson KJ, Bateman LA, Lin H, Kamenecka T, Lokurkar IA, Lou J, Rao RR, Chang MR, Jedrychowski MP, Paulo JA, Gygi SP, Griffin PR, Nomura DK, Spiegelman BM. PM20D1 secretion by thermogenic adipocytes regulates lipidated amino acid uncouplers of mitochondrial respiration. Cell 2016; 166(2):424-435.

Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chedotal A, Kajimura S, Gygi SP, Spiegelman BM. A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab. 2016; 23(3):454-466.

Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P, Vetrivelan R, Lu GZ, Laznik-Bogoslavski D, Hasenfuss SC, Kajimura S, Gygi SP, Spiegelman BM. A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat. Cell 2015; 163(3):643-655.

Cohen, P., Levy, J., Zhang, Y., Frontini, A., Kolodin, D., Svensson, K., Lo, J., Zeng, X., Ye, L., Khandekar, M., et al. (2014). Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell 156, 304-316.

Long, J., Svensson, K., Tsai, L., Zeng, X., Roh, H., Kong, X., Rao, R., Lou, J., Lokurkar, I., Baur, W., et al. (2014). A Smooth Muscle-Like Origin for Beige Adipocytes. Cell metabolism.

Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM. Beige Adipocytes are a Distinct Type of Thermogenic Fat Cell in Mouse and Human.
Cell. 2012 Jul 20;150(2):366-76.

Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.
Nature. 2012 Jan 11;481(7382):463-8.

Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scimè A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. PRDM16 controls a brown fat/skeletal muscle switch.
Nature. 2008 Aug 21;454(7207):961-7.

Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jager S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
Cell. 2004 Oct 1;119(1):121-35.

Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres.
Nature. 2002 Aug 15;418(6899):797-801.

Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Cell. 1998 Mar 20;92(6):829-39.

Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.
Cell. 1994 Dec 30;79(7):1147-56.

 

Selected Reviews

Chouchani ET, Kazak L, Spiegelman BM.  Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms.  J Biol Chem. 2017;  292(41):16810-16816.

Cohen P, Spiegelman BM.  Cell biology of fat storage.  Mol Biol Cell. 2016;  27(16):2523-2527.

Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: Is beige the new brown? Genes Dev. 2013 Feb 1;27(3):234-50.

Gupta RK, Rosen ED, Spiegelman BM. Identifying novel transcriptional components controlling energy metabolism. Cell Metab. 2011 Dec 7;14(6):739-45.

Khandekar MJ, Cohen P, Spiegelman BM. Molecular mechanisms of cancer development in obesity. Nat Rev Cancer. 2011 Nov 24;11(12):886-95.

Handschin C, Spiegelman BM.The role of exercise and PGC1alpha in inflammation and chronic disease.Nature. 2008 Jul 24;454(7203):463-9.

 

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Last Update 08/2010