Selected Papers

Rao, R.R., Long, J.Z., White, J.P., Svensson, K.J., Lou, J., Lokurkar, I., Jedrychowski, M.P., Ruas, J.L., Wrann, C.D., Lo, J.C., et al. (2014). Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis. Cell 157, 1279–1291.

Cohen, P., Levy, J., Zhang, Y., Frontini, A., Kolodin, D., Svensson, K., Lo, J., Zeng, X., Ye, L., Khandekar, M., et al. (2014). Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell 156, 304-316.

Long, J., Svensson, K., Tsai, L., Zeng, X., Roh, H., Kong, X., Rao, R., Lou, J., Lokurkar, I., Baur, W., et al. (2014). A Smooth Muscle-Like Origin for Beige Adipocytes. Cell metabolism.

Wrann, C., White, J., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J., Greenberg, M., and Spiegelman, B. (2013). Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell metabolism 18, 649-659.

Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM. A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell. 2012 Dec 7;151(6):1319-31.

Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis.
Cell. 2012 Sep 28;151(1):96-110.

Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM. Beige Adipocytes are a Distinct Type of Thermogenic Fat Cell in Mouse and Human.
Cell. 2012 Jul 20;150(2):366-76.

Gupta RK, Mepani RJ, Kleiner S, Lo JC, Khandekar MJ, Cohen P, Frontini A, Bhowmick DC, Ye L, Cinti S, Spiegelman BM. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells.
Cell Metab. 2012 Feb 8;15(2):230-9.

Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis.
Genes Dev. 2012 Feb 1;26(3):271-81.

Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.
Nature. 2012 Jan 11;481(7382):463-8.

Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schürer SC, Vidović D, Shulman GI, Spiegelman BM, Griffin PR.
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.
Nature. 2011 Sep 4. doi: 10.1038/nature10383.

Boström P, Mann N, Wu J, Quintero PA, Plovie ER, Panáková D, Gupta RK, Xiao C, MacRae CA, Rosenzweig A, Spiegelman BM.
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.
Cell. 2010 Dec 23;143(7):1072-83.

Choi JH, Banks AS, Estall JL, Kajimura S, Boström P, Laznik D, Ruas JL, Chalmers MJ, Kamenecka TM, Blüher M, Griffin PR, Spiegelman BM.
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.
Nature. 2010 Jul 22;466(7305):451-6

Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM.
Transcriptional control of preadipocyte determination by Zfp423.
Nature. 2010 Mar 25;464(7288):619-23.

Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM.
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.
Nature. 2009 August 27; 460(7259): 1154–1158.

Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scimè A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM.
PRDM16 controls a brown fat/skeletal muscle switch.
Nature. 2008 Aug 21;454(7207):961-7.

Arany, Z, Foo S-Y, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Rangwala S, Rosenzweig A and Spiegelman BM.
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1.
Nature. 2008 Feb 21;451(7181):1008-12.

Handschin C, Kobayashi YM, Chin S, Seale P, Campbell KP and Spiegelman BM.
PGC-1a regulates the neuromuscular junction program and ameliorates Duchenne muscular dystropy.
Genes & Dev. 2007; 21:770-783.

Seale P, Kajimura S, Yang W, Chin S, Rohas L, Uldry M, Tavernier G, Langin D and Spiegelman BM.
Transcriptional control of brown fat determination by PRDM16.
Cell Metabolism 2007; 6:38-54.

St. Pierre J, Drori D, Uldry M, Silvaggi J, Rhee J, Jaeger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R and Spiegelman BM.
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.
Cell 2006; 127:397-402.

Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM.
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation.
Cell Metab. 2006 May;3(5):333-41.

Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jager S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM.
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
Cell. 2004 Oct 1;119(1):121-35.

Girnun GD, Smith WM, Drori S, Sarraf P, Mueller E, Eng C, Nambiar P, Rosenberg DW, Bronson RT, Edelmann W, Kucherlapati R, Gonzalez FJ, Spiegelman BM.
APC-dependent suppression of colon carcinogenesis by PPARgamma.
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13771-6.

Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, Spiegelman BM.
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway.
Genes Dev. 2002 Jan 1;16(1):22-6.

Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM.
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres.
Nature. 2002 Aug 15;418(6899):797-801.

Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM.
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Cell. 1998 Mar 20;92(6):829-39.

Tontonoz P, Hu E, Spiegelman BM.
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.
Cell. 1994 Dec 30;79(7):1147-56.

 

Selected Reviews

Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: Is beige the new brown? Genes Dev. 2013 Feb 1;27(3):234-50.

Gupta RK, Rosen ED, Spiegelman BM. Identifying novel transcriptional components controlling energy metabolism. Cell Metab. 2011 Dec 7;14(6):739-45.

Khandekar MJ, Cohen P, Spiegelman BM. Molecular mechanisms of cancer development in obesity. Nat Rev Cancer. 2011 Nov 24;11(12):886-95.

Handschin C, Spiegelman BM.The role of exercise and PGC1alpha in inflammation and chronic disease.Nature. 2008 Jul 24;454(7203):463-9.

Tontonoz P, Spiegelman BM. Fat and beyond: the diverse biology of PPARgamma.
Annu Rev Biochem. 2008;77:289-312.

Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis.
Nature. 2006 Dec 14;444(7121):847-53. Review.

Spiegelman BM, Enerbäck S. The adipocyte: a multifunctional cell.
Cell Metab. 2006 Dec;4(6):425-7.

Handschin C, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.
Endocr Rev. 2006 Dec;27(7):728-35

Lin J, Handschin C, Spiegelman BM.
Metabolic control through the PGC-1 family of transcription coactivators.
Cell Metab. 2005 Jun;1(6):61-70.

Puigserver P, Spiegelman BM.
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.
Endocr Rev. 2003 Feb;24(1):78-90.

Spiegelman BM, Flier JS.
Obesity and the regulation of energy balance.
Cell. 2001 Feb 23;104(4):531-43.

Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM.
Transcriptional regulation of adipogenesis.
Genes Dev. 2000 Jun 1;14(11):1293-307.

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Last Update 08/2010