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Development & Cell Differentiation Molecular Cancer Therapeutics Megakaryocytes & Platelets Developmental Hematopoiesis Development & Cell Differentiation Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA. A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development 2006; In Press. Hu M, Shivdasani RA. Overlapping gene expression in fetal mouse intestine development and human colorectal cancers Cancer Research 2005; 65:8715-8722 | pdf Kim BM, Buchner G, Miletich I, Sharpe PT, Shivdasani RA. The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Developmental Cell, Vol 8, 611-622, April 2005 | pdf Drori S, Girnun GD, Tou L, Szwaya JD, Mueller E, Kia X, Shivdasani RA, Spiegelman B Hic-5 regulates an epithelial program mediated by PPAR-y Genes & Development, 19:362-375, 2005 | pdf Lepourcelet M, Tou L, Cai L, Sawada J, Lazar AF, Glickman JN, Williamson J, Everett AD, Redston M, Fox EA, Nakatani Y, Shivdasani RA. Insights into developmental mechanisms and cancers in the mammalian intestine derived from SAGE and study of the hepatoma-derived growth factor (HDGF). Development site 2005; 132:415-427 | pdf Tou L, Liu Q, Shivdasani RA. Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Mol Cell Biol 2004; 24:3132-3139 | pdf Malik TH, von Stechow D, Bronson RT, Shivdasani RA. Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into bone disorder in inherited tricho-rhino-phalangeal syndromes. Mol Cell Biol 2002; 22:8592-8600 | pdf Shivdasani, RA. Molecular Regulation of Vertebrate Early Endoderm Development. Dev Biol 249, 191-203. 2002 [review] | pdf Lepourcelet M, Shivdasani RA. Characterization of a novel mammalian Groucho isoform and its role in transcriptional regulation. J Biol Chem 2002; 49:47732-47740 | pdf Zhang J, Rosenthal A, de Sauvage FJ, Shivdasani RA. Downregulation of hedgehog signaling is required for organogenesis of the small intestine in Xenopus. Dev Biol 2001; 229:188-202 | pdf Malik TH, Shoichet SA, Latham P, Kroll T, Peters LL, Shivdasani RA. Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1. EMBO J 2001; 20:1715-1725 | pdf Shoichet SA, Malik TH, Rothman JH, Shivdasani RA. Action of the C. elegans GATA factor END-1 in Xenopus suggests that similar mechanisms initiate endoderm development in ecdysozoa and vertebrates. Proc Natl Acad Sci USA 2000; 97:4076-4081 | pdf Malik TH, Shivdasani RA. Structure and expression of a novel Frizzled gene isolated from the developing mouse gut. Biochem J 2000; 349:829-834. Lee YJ, Swencki B, Shoichet S, Shivdasani RA. A possible role for the High Mobility Group-box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation. J Biol Chem 1999; 274:1566-1572 | pdf top Molecular Cancer Therapeutics Lepourcelet M, Chen YP, Frances DS, Wang H, Crews P, Petersen F, Bruseo C, Wood AW, Shivdasani RA. Small molecule antagonists of the oncogenic beta-cetenin/Tcf protein complex. Cancer Cell, 2004; 5:91-102 | pdf Livingston DM, Shivdasani RA. Toward mechanism-based cancer care. JAMA 2001; 285:588-593 [Review] Poy F, Lepourcelet M, Shivdasani RA, Eck MJ. Structure of a human Tcf4/b-catenin complex. Nature Struct Biol 2001; 8:1053-1057 | pdf Megakaryocytes & Platelets Schulze H, Korpal M, Hurov J, Kim S-W, Zhang J, Cantley LC, Graf T, Shivdasani RA. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood 2006; 107:3868-3875 | pdf Richardson J, Shivdasani RA, Boers C, Hartwig JH, Italiano JE Jr. Mechanisms of organelle transport and capture along proplatelets during platelet production. Blood 2005; 106:4066-4075 | pdf Patel SR, Richardson J, Schulze H, Kahle E, Galjart N, Drabek K, Shivdasani RA, Hartwig JH, Italiano JE Jr. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood 2005; 106:4076-4085 | pdf Schulze H, Korpal M, Bergmeier W, Italiano JE, Wahl SM, Shivdasani RA. Interactions between the megakaryocyte/platelet-specific 1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions. Blood, 2004; 104: 3949-3957 | pdf Tiwari S, Italiano JE, Barral DC, Mules EH, Novak EK, Swank RT, Seabra MC, Shivdasani RA. A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood, 2003; 102:3970-3979 | pdf Italiano JE, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister K, Andre P, Wagner DD, Shivdasani RA. Mechanisms and implications of platelet discoid shape. Blood 2003; 101:4789-4796 | pdf Italiano JE, Shivdasani RA. Megakaryocytes and beyond: the birth of platelets. J Thromb Haemost, 2003; 1:1174-1181. Shivdasani RA. Molecular and transcriptional regulation of megakaryocyte differentiation. Stem Cells 2001; 19:397-407. [Review] Schwer HD, Lecine P, Tiwari S, Italiano JE, Hartwig JH, Shivdasani RA. A lineage-restricted and divergent b tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol 2001; 11:579-586. | pdf Lecine P, Italiano JE, Kim SW, Villeval J-L, Shivdasani RA. Hematopoietic-specific beta1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. Blood 2000; 96:1366-1373. | pdf Vyas P, Ault K, Jackson CW, Orkin SH, Shivdasani RA. Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood 1999; 93:2867-2875. | pdf Levin J, Peng J-P, Baker GR, Villeval J-L, Lecine P, Burstein SA, Shivdasani RA. Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2. Blood 1999; 94: 3037-3047. | pdf Italiano JE, Lecine P, Shivdasani RA, Hartwig JH. Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol 1999; 147:1299-1312. | pdf de Sauvage FJ, Villeval J-L, Shivdasani RA. Regulation of megakaryocytopoiesis and platelet production: Lessons from animal models. J Lab Clin Med 1998; 131:496-501. [Review] Lecine P, Blank V, Shivdasani RA. Characterization of the hematopoietic transcription factor NF-E2 in primary murine megakaryocytes. J Biol Chem 1998; 273:7572-7578. | pdf Lecine P, Villeval J-L, Vyas P, Swencki B, Xu Y, Shivdasani RA. Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes. Blood 1998; 92:1609-1616. | pdf Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J 1997;16:3965-3973. | pdf Shivdasani RA, Fielder P, Keller G-A, Orkin SH, de Sauvage FJ. Regulation of the serum concentra-tion of thrombopoietin in thrombocytopenic NF-E2 knockout mice. Blood 1997; 90:1821-1827. Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJM, Orkin SH. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell 1995;81:695-704. top Developmental Hematopoiesis Schulze H, Korpal M, Hurov J, Kim S-W, Zhang J, Cantley LC, Graf T, Shivdasani RA. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood 2006; 107:3868-3875 | pdf Kacena MA, Shivdasani RA, Wilson K, Xi Y, Troiano N, Nazarian A, Gundberg CM, Bouxsein ML, Lorenzo JA, Horowitz MC. Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2. J Bone Miner Res 2004; 19:652-660 | pdf McDevitt MA, Fujiwara Y, Shivdasani RA, Orkin SH. An upstream, DNaseI hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice. Proc Natl Acad Sci USA 1997;94:7976-7981 | pdf Shivdasani RA, Orkin SH. The transcriptional control of hematopoiesis. Blood 1996; 87:4025-4039 [Review] pdf Peters LL, Shivdasani RA, Liu SC, Hanspal M, John KM, Gonzalez JM, Brugnara C, Gwynn B, Mohandas N, Alper SL, Orkin SH, Lux SE. Anion exchanger 1 (Band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell 1996;86:917-927 | pdf Shivdasani RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein Tal-1/SCL. Nature 1995;373:432-434 Shivdasani RA, Orkin SH. Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Proc Natl Acad Sci USA 1995;92:8690-8694 | pdf top |
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