SHIH LABORATORY

Biomolecular Nanotechnology Group
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Harvard Medical Schoolhttp://hms.harvard.edu/hms/home.asp
Dana-Farber
Cancer Institutehttp://www.dfci.harvard.edu/
Wyss
Institutehttp://wyss.harvard.edu/

Welcome to the Shih Lab. We explore design principles for self-assembling molecular machines, primarily using structural DNA nanotechnology to build our model systems. We seek to apply our knowledge towards construction of artificial systems that help solve problems of biological and medical interest. Currently we focus on building tools for molecular biophysics (NMR structure determination of membrane proteins, single-molecule assays) and for therapeutics (drug delivery, tissue engineering). For many applications, our present capabilities are too primitive. Thus we also investigate enabling technologies for increasing the complexity of programmable self-assembled systems.


We encourage you to visit http://cadnano.org/, 3D-DNA-origami CAD software maintained by Shawn Douglas (the lead developer). There you can find downloads, tutorials, and galleries.

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