Novina Lab

Original Articles

Hakre S, Tussie-Luna MI, Ashworth T, Novina CD, Settleman J, Sharp PA, Roy AL.
Opposing Functions of TFII-I Spliced Isoforms in Growth Factor-Induced Gene Expression.
Mol Cell. 2006; 24(2):301-308. PubMed

Del Gazio Moore V, Brown JR, Certo M, Love TM, Novina CD, Letai A.
Chronic Lymphocytic Leukemia Requires BCL2 to Sequester Prodeath BIM.
J Clin Invest 2007; 117: Online Publication Available. Pubmed

Wang B, Love TM, Call ME, Doench JG, Novina CD.
Recapitulation of short RNA-directed translational gene silencing in vitro.
Mol Cell. 2006 May 19;22(4):553-60. PubMed

Oka T, Vasile E, Perman M, Novina CD, Dykxhoorn DM, Ungar D, Hughson FM, and Krieger M.
Genetic analysis of the subunit organization and function of the COG complex: Studies of COG5 and COG7 deficient mammalian cells.
J. Biol. Chem. 2005; 280:38 32736-45 PubMed

Song E, Lee S-K, Dykxhoorn DM, Novina CD, Zhang D, Crawford K, Cerny J, Sharp PA, Lieberman J, Manjunath N, Shankar P
Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages
J. Virol. 2003; 77: 7174-81 PubMed

Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen ISY, Hahn WC, Sharp PA, Weinberg RA, Novina CD
Lentivirus-delivered stable gene silencing by RNAi in primary cells
RNA 2003; 9: 493-501 PubMed

Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J
Cleaving the oxidative repair protein ApeI enhances cell death mediated by granzyme A
Nat. Immunol. 2003; 4: 145-153 PubMed

Novina CD, Murray MF, Dykxhoorn DM, Beresford PJ, Riess J, Lee S-K, Collman RG, Lieberman J, Shankar P, Sharp PA
siRNA-directed inhibition of HIV-1 infection
Nat. Med. 2002; 8: 681-686 PubMed

Morikawa N, Clarke TR, Novina CD, Watanabe K, Haqq C, Weiss M, Roy AL, Donahoe PK
Human Mullerian-inhibiting substance promoter contains a functional TFII-I binding initiator
Biol. Reprod. 2000; 63: 1075-1083 PubMed

Novina CD, Kumar S, Bajpai U, Cheriyath V, Zhang K, Pillai S, Wortis HH, Roy AL
Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton’s tyrosine kinase
Mol. Cell. Biol. 1999; 19: 5014-5024 PubMed

Cheriyath V, Novina CD, Roy AL
TFII-I regulates Vb promoter activity through an initiator element
Mol. Cell. Biol. 1998; 18: 4444-4454 PubMed

Novina CD, Cheriyath V, Roy AL
Regulation of TFII-I activity by phosphorylation
J. Biol. Chem. 1998; 273: 33443-33448 PubMed

Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG
Cloning of an Inr- and E-box binding protein, TFII-I that interacts physically and functionally with USF1
EMBO J. 1997; 23: 7091-7104 PubMed

Greuneberg DA, Henry RW, Brauer A, Novina CD, Cheriyath V, Roy AL, Gilman M
A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I
Genes Dev. 1997; 11: 2482-2493 PubMed

Montano MA, Kripke K, Novina CD, Achacoso P, Herzenberg LA, Roy AL, and Nolan GP
NF-kB homodimer binding within the HIV-1 initiator region and interactions with TFII-I
Proc. Natl. Acad. Sci., USA 1996; 93: 12376-12381

Manzano-Winkler B, Novina CD, Roy AL
TFII-I is required for transcription of the naturally TATA-less but Initiator-Containing Vb promoter
J. Biol Chem 1995; 271: 12076-12081 PubMed

Reviews, Chapters, and Editorials

Chowdhury D, and Novina CD
RNAi & RNA-based regulation of immune system function
Adv. Immunol 2005; accepted

Chowdhury D, and Novina CD
Potential roles for short RNAs in lymphocytes
Immunol. Cell Biol. 2005; 83, 210-10 PDF (1.5 MB)
This article was published in Immunology Cell Biology, 2005; 83, 201-10, available online at Blackwell Synergy.

Doench, JD and Novina CD
RNA Interference
Encyclopedia of Molecular Cell Biology and Molecular Medicine (EMCBMM) entry: 2005; accepted

Novina, CD
Therapeutic potential of RNA interference
Biomed. Pharmacother. 2004; 58:270

Novina CD, and Sharp PA
The RNAi revolution
Nature 2004; 430:161-164 PubMed

Dykxhoorn DM, Novina CD, and Sharp PA
Killing the messenger: short RNAs that silence gene expression
Nat. Rev. Mol. Cell Biol. 2003; 4: 457-467 PubMed

Novina CD, Cheriyath V, Denis MC, Roy AL
Methods for studying the biochemical properties of an Inr element binding protein: TFII-I
Methods: Companion to Methods Enzymol. 1997; 12: 254-263 PubMed

Novina CD, and Roy AL
Core promoters and transcriptional control
Trends Genet. 1996; 12:351-355 PubMed