Research Articles

  1. Lane AA, Chapuy B, Lin CY, Tivey T, Li H, Townsend EC, van Bodegom D, Day TA, Wu SC, Alexe G, Schinzel AC, Sullivan TJ, Malinge S, Taylor JE, Stegmaier K, Jaffe JD, Bustin M, Te Kronnie G, Izraeli S, Harris MH, Stevenson KE, Neuberg D, Silvermann LB, Sallan SE, Bradner JE, Hahn WC, Crispino JD, Pellman D, Weinstock DM. Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimenthylation. Nat Genet 2014, April [Epub ahead of print]
  2. Ganem N, Cornils H, Chiu S, O’Rourke K, Arnaud J, Yimlamai D, Thery M, Carmargo FD, Pellman D. Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation. Cell 2014; 158: 833-48. PMID:25126788
  3. Godinho S, Picone R, Burute M, Dagher R, Leung CT, Polyak K, Brugge JS, Thery M, Pellman D. Oncogene-like induction of cellular invasion from centrosome amplification. Nature 2014; 510: 167-71. PMID: 24739973 PMCID: PMC4061398
  4. Atkins BD, Yoshida S, Saito K, Wu CF, Lew DJ, Pellman D. Inhibition of Cdc42 drung mitotic exit is required for cytokinesis. J Cell Biol 2013; 202: 231-40. PMCID: PMC3718968
  5. Su X, Arellano-Santoyo H, Portran D, Gaillard J, Vantard M, Thery M, Pellman D. Microtubule sliding activity of a kinesin-8 promotes spindle assembly and spindle length control. Nat Cell Biol 2013; 15: 948-57. PMID: 23851487
  6. Buttery SM, Kono K, Stokasimov E, Pellman D. Regulation of the formin Bnr1 by septins and a MARK/Par1-family septin-associated kinase. MBoC 2012; 23: 4041-53. PMID: 22918953 PMCID: PMC3469519
  7. Carter SL, Cibulskis K, Helman E, McKenna A, Shen H, Zack T, Laird PW, Onofrio RC, Winckler W, Weir BA, Beroukhim R, Pellman D, Levine DA, Lander ES, Meyerson M, Getz G. Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol 2012; 30: 413-21. PMID: 22544022
  8. Kono K, Saeki Y, Yoshida S, Pellman D. Proteasomal degradation resolves competition between cell polarization and cellular would healing. Cell 2012; 6;150(1):151-64. Epub 2012 Jun 21
  9. Crasta K, Ganem NJ, Dagher R, Lantermann AB, Ivanova EV, Pan Y, Nezi L, Protopopov A, Chowdhury D, Pellman D. DNA breaks and chromosome pulverization from errors in mitosis. Nature. 2012 Jan 18. [Epub ahead of print]
  10. Su X, Qiu W, Gupta ML Jr, Pereira-Leal JB, Reck-Peterson SL, Pellman D. Mechanisms Underlying the Dual-Mode Regulation of Microtubule Dynamics by Kip3/Kinesin-8. Mol Cell. 2011 Sep 2; 43(5): 751-763.
  11. Storchova Z, Becker JS, Talarek N, Kogelsberger S, Pellman D. Bub1, Sgo1, and Mps1 mediate a distinct pathway for chromosome biorientation in budding yeast. Mol Bio Cell. 2011 May;22(9):1473-85
  12. Ganem NJ, Godinho SA, Pellman D. A Mechanism Linking Extra Centrosomes to Chromosomal Instability. Nature. 2009 July 9;460:278-82
  13. Yoshida S, Bartolini S, Pellman D. Mechanisms for concentrating Rho1 during cytokinesis.Genes Dev. 2009 Apr 1;23(7):810-23
  14. Kwon M*, SA Godinho*, Chandhok NS, Ganem NJ, Azioune A, Thery M, Pellman D.Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.Genes Dev. 2008 Aug 15;22(16):2189-203
  15. Buttery SM, Yoshida S, Pellman D.Yeast formins Bni1 and Bnr1 utilize different modes of cortical interaction during the assembly of actin cables.Mol Biol Cell. 2007 May;18(5):1826-38
  16. Storchova Z, Breneman A, Cande J, Dunn J, Burbank K, O'Toole E, Pellman D. Genome-wide genetic analysis of polyploidy in yeast. Nature. 2006 Oct 5;443(7111):541-7
  17. Yoshida S, Kono K, Lowery DM, Bartolini S, Yaffe MB, Ohya Y & Pellman D.Polo-Like Kinase Cdc5 Controls the Local Activation of Rho1 to Promote Cytokinesis. Science. 2006 July 7:313 (5783) 108-111
  18. Gupta ML Jr, Carvalho P, Roof DM, Pellman D. Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle. Nat Cell Biol. 2006 Sep;8(9):913-23.
  19. Talarek N, Maillet L, Cullin C, Aigle M. The [URE3] prion is not conserved among Saccharomyces species. Genetics. 2005 Sep; 171(1): 23-34
  20. Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT & Pellman D. Cytokinesis failure, generating aneuploidy, promotes tumorigenesis in p53-null cells. Nature 2005; 437(7061):1043–7
  21. Andalis A, Storchova Z, Galitski T, Styles C, Pellman D, and Fink G. Polyploidy in Saccharomyces cerevisiae leads to stationary phase death. Genetics 2004; 167(3):1109–21
  22. Mosley JB, Sagot I, Manning AL, Xu Y, Eck MJ, Pellman D, and Goode BL. A conserved mechanism for Bni1- and mDia-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin. Epub 2003, Mol Biol Cell 2004; 15:896–907
  23. Carvalho P, Gupta M, Pellman D. Cell Cycle Control of Kinesin–Mediated Transport of Bik1 (CLIP-170) Regulates Microtubule Stability and Dynein Activation. Dev Cell 2004; 6:815–29
  24. Xu Y, Sagot I, Moseley JB, Poy F, Goode BL, Pellman D, and Eck MJ. Crystal Structures of a Formin Homology-2 Domain Reveal a Tethered Dimer Architecture. Cell 2004; 116:1–20
  25. Molk JN, Schuyler SC, Liu JY, Evans JG, Salmon ED, Pellman D, and Bloom K. The differential roles of budding yeast Tem1p, Cdc15p, and Bub2p protein dynamics in mitotic exit. Mol Biol Cell 2004; 15:1519–32
  26. Chestukin A, Pfeffer C, Milligan S, DeCaprio JA, Pellman D. Processing, localization, and requirement of human separase for normal anaphase progression. Proc Natl Acad Sci USA 2003; 100:4574–9
  27. Sheeman B, Carvalho P, Sagot I, Geiser J, Kho D, Hoyt MA, Pellman D. Determinants of S. cerevisiae dynein microtubule plus end localization and activation: implications for the mechanism of spindle positioning. Curr Biol 2003; 13:364–72
  28. Schuyler SC, Liu JY, Pellman D. The molecular function of Ase1p: evidence for a MAP-dependent midizone-specific spindle matrix. J Cell Biol 2003; 160:517–28.
  29. Sagot I, Rodal A, Goode B, Pellman D. An actin nucleation mechanism mediated by the formin Bni1 and profilin. Nature Cell Biol 2002; 8:626–31
  30. Sagot I, Klee SK, Pellman D. Yeast formins regulate cell polarity by controlling the assembly of actin cables. Nature Cell Biol 2002; 4:42–50
  31. Lin H, de Carvalho P, Kho D, Tai CY, Pierre P, Fink GR, Pellman D. Polyploids Require Bik1p for Kinetochore-Microtubule Attachment. J Cell Biol 2001; 155:1173–1184
  32. Lechler T, Jonsdottir G, Klee SK, Pellman D, Li R: A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating complex in yeast. J Cell Biol 2001; 155:261–70
  33. Huang J, Park I, Ellingson E, Littlepage LE, Pellman D. Activity of the APCCdh1 Form of the Anaphase Promoting Complex Persists Throughout G1 and Prevents the Premature Expression of Cdc20p. J Cell Biol 2001; 154:85–94
  34. Jonsson ZO, SK, Narlikar GJ, Auty R, Wagle N, Pellman D, Pratt RE, Kingston R, Dutta A. Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes. J Biol Chem 2000; 276:16279–16288
  35. Lee L, Tirnauer JS, Li J, Schuyler SC, Pellman D. Positioning of the mitotic spindle by a cortical-microtubule capture mechanism. Science 2000; 287:2260–2262
  36. Tirnauer J, Berrueta L, Bierer B, Pellman D. Cell cycle-specific regulation of microtubule dynamics by the cytokinesis checkpoint protein, Bim1p. J Cell Biol 1999; 145:993–1007
  37. Berrueta L, Tirnauer JS, Schuyler SC, Pellman D, Bierer BE. The APC-associated protein EB1 associates with dynactin members and cytoplasmic dynein intermediate chain. Curr Biol 1999; 9:425–428
  38. Lee L, Klee S, Evangelista M, Boone C, Pellman D. Control of mitotic spindle position by the yeast formin, Bni1p. J Cell Biol 1999; 144:947–961
  39. Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE. The APC-Binding Protein Eb1 is associated with cytoplasmic and spindle microtubules. Proc Natl Acad Sci 1998; 95:10596–601
  40. DeZwaan TM, Ellingson E, Pellman D, Roof DM. Kinesin-related KIP3 of Saccaromyces cerevisiae is required for a distinct step in nuclear migration. J Cell Biol 1997;138:1023–1040
  41. Juang YL, Huang J, Peters JM, McLaughlin ME, Tai CY, Pellman D. APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle. Science 1997; 75:1311–1314
  42. Loeb JL, Schlenstedt G, Pellman D, Kornitzer D, Silver PA, and Fink GR. A nuclear import receptor homologue required for mitosis in yeast. Proc Natl Acad Sci 1995;9 2:7647–7651
  43. Pellman D, Baggett M, and Fink GR. Two microtubule-associated proteins required or anaphase spindle movement in Saccharomyces cerrevisiae. J Cell Biol 1995; 130:1373–1385
  44. Pellman D, McLaughlin ME, and Fink GR. TATA-dependent and TATA-independent transcription at the HIS4 gene of yeast. Nature 1990; 348:82–85
  45. Stoeckle MY, Sugano S, Hampe A, Vashistha A, Pellman D, Hanafusa H. 78-Kilodalton glucose-regulated protein is induced in Rous Sarcoma Virus-transformed cells independently of glucose deprivation. Mol Cell Biol 1988; 8:2675–2680
  46. Pellman D, Garber EA, Cross FR, Hanafusa H. An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins. Nature 1985; 314:374–377
  47. Pellman D, Garber EA, Cross FR, Hanafusa H. Fine structural mapping of a critical NH2-terminal region of p60src. Proc Natl Acad Sci USA 1985; 82:1623–1627
  48. Cross FR, Garber EA, Pellman D, Hanafusa H. A short sequence in the p60src N-terminus is required for p60src myristylation and membrane association and for cell transformation. Mol Cell Biol 1984; 4:1834–1842

Review Articles

  1. Zhang CZ, Leibowitz ML, Pellman D. Chromothripisis and beyond: rapid genome evolution from complex chromosomal rearrangements. Genes Dev 2013; 27: 2513-30 PMCID: PMC3861665
  2. Ganem NJ, Pellman D. Linking abnormal mitosis to the acquisition of DNA damage. J Cell Biol 2012; 199: 871-81. PMID 23229895 PMCID: PMC351822
  3. Su X, Ohi R, Pellman D. Moving in for the kill: Motile microtubule regulators. Trends in Cell Biology 2012; 22: 567-75, PMID: 2295403 PMCID: PMC3482944
  4. Varetti G, Pellman D. “Two” much of a good thing: telomere damage-induced genome doubling drives tumorigenesis. Cancer Cell 2012; 21: 712-4
  5. Gordon DJ, Resio B, Pellman D. Causes and consequences of aneuploidy in cancer. Nat Rev Genet. 2012 Jan 24.[Epub ahead of print]
  6. Bettencourt-Dias M, Hildebrandt F, Pellman D, Woods G, Godinho SA. Centrosomes and cilia in human disease. Trends Genet. 2011 Aug;27(8):307-15. Epub 2011 Jun 15.
  7. Chandhok NS, Pellman D. A little CIN may cost a lot: revisiting aneuploidy and cancer. Curr Opin Genet Dev. 2009 Feb;19(1):74-81.
  8. Godinho SA, Kwon M, Pellman D. Centrosomes and cancer: how cancer cells divide with too many centrosomes. Cancer Metastasis Rev. 2009 Jun;28(1-2):85-98.
  9. Atkins BD, Yoshida S, Pellman D. Symmetry breaking: scaffold plays matchmaker for polarity signaling proteins. Curr Biol. 2008 Dec 23;18(24):R1130-2.
  10. Yoshida S, Pellman D. Plugging the GAP between cell polarity and cell cycle. EMBO Rep. 2008 Jan;9(1):39-41.
  11. Ceol CJ, Pellman D, Zon LI. APC and colon cancer: two hits for one. Nat Med. 2007 Nov;13(11):1286-7.
  12. Jallepalli PV, Pellman D. Cell biology. Aneuploidy in the balance. Science. 2007 Aug 17;317(5840):904-5.
  13. Pellman D. Cell biology: aneuploidy and cancer. Nature. 2007 Mar 1;446(7131):38-9.
  14. Ganem NJ, Pellman D. Limiting the proliferation of polyploid cells. Cell. 2007 Nov 2;131(3):437-40.
  15. Ganem NJ, Storchova Z, Pellman D. Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev. 2007 Apr;17(2):157-62.
  16. Yoshida S, Guillet M, Pellman D. MEN signaling: daughter bound pole must escape her mother to be fully active. Dev Cell. 2005, Aug; 9(2)168–170
  17. Carvalho P, and Pellman D. Mitotic spindle: laser microsurgery in yeast cells. Curr biol. 2004, Sep; 14(18): R748–50
  18. Storchova Z, Pellman D. Polyploidy and aneuploidy: implications for genome stability and cancer. Nat Rev Mol Cell Biol 2004, Jan; 5(1):45–54
  19. Carvalho P, Pellman D. Surfing on microtubule ends. Trends Cell Biol 2003; 13:229–237
  20. Schuyler S, Pellman D. Analysis of the Size and Shape of Protein Complexes from Yeast. Methods Enzymol 2002; 351:150–168
  21. Yarm F, Sagot I, Pellman D. The social life of actin and microtubules: interaction versus cooperation. Curr Opin Microbiol 2001; 4:696–702
  22. Christman MF, Pellman D. Separase anxiety: dissolving the sister bond and more. Nat Cell Biol 2001; 9:207–9
  23. Schuyler S, Pellman D. Microtubule plus end tracking proteins: the end is just the beginning. Cell 2001; 105:421–4
  24. Pellman D. Twenty ways of looking at a centrosome. Cell 2001;105:309–310
  25. Pellman D. Genome Stability and Cancer; CINtillating New Role for the APC Tumor Suppressor. Science 2001; 291:2555–2556
  26. Schuyler S, Pellman D. Search Capture and Signal: Games the Microtubules and Centrosomes Play. J Cell Sci 2000; 114:247–255
  27. D'Andrea A, Pellman D. Deubiquitinating enzymes: a new class of biological regulators. Crit Rev Biochem Mol Bio 1998; 33:337–352
  28. Iba H, Takeya T, Cross FR, Garber EA, Hanafusa T., Pellman D, Hanafusa H. "Differences in the biological function of viral and cellular src genes." In: Mark P, editor. Genetics, Cell Differentiation and Cancer. Vol. 7. Orland o: Academic Press, Inc; 1985