I am interested in the causes of DNA damage that shape the genome. Specifically, I am looking at how DNA replication can yield DNA double strand breaks and structural variation.
Graduate Student, Biological and Biomedical Sciences, Harvard University, Cambridge, Massachusetts
BS, University of Virginia, Charlottesville, Virginia
Leibowitz, ML*, Zhang, CZ*, Pellman, D. Chromothripsis: A new mechanism for rapid karyotype evolution. Annu. Rev. Genet. 49: 183-211 (2015).
Zhang, CZ*, Leibowitz, ML*, Pellman, D. Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements. Genes & Development. 27: 2513-2530 (2014).
Malhotra, A, Lindberg, M, Faust, GG, Leibowitz, ML, Clark, RA, Layer RM, Quinlan, AR, Hall, IM. Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms. Genome Res 23: 762-776 (2013).
Quinlan, AR, Boland MJ, Leibowitz, ML, Shumilina, S, Pehrson, SM, Baldwin, KK, Hall, IM. Genome sequencing of mouse induced pluripotent stem cells reveals retroelement stability and infrequent DNA rearrangement during reprogramming. Cell Stem Cell 9: 366-373 (2011).
Quinlan, AR, Clark, RA, Sokolova, S, Leibowitz, ML, Zhang, Y, Hurles, ME, Mell, JC, Hall, IM. Genome-wide mapping and assembly of structural variant breakpoints in the mouse genome. Genome Res 20: 623-635 (2010).