Mijung Kwon is interested in finding out how cell division works in normal and cancer cells, and how
such insight can be used to develop selective anti-cancer drugs. Centrosome amplification is a hallmark
of cancer. Being interested in deciphering how cancer cells prevent chaotic mitoses in the presence of
extra centrosomes, her research is focused on identifying molecular machinery and mechanisms that
organizes extra centrosomes during cell division. Currently, she combines multiple approaches including
functional genomics, high-resolution imaging, computational image analysis and mathematical modeling
to provide new insight into mechanisms controlling cell division and genome stability.
|2010-present||Instructor in Pediatric Oncology, HMS & DFCI |
|2009–2012||Leukemia and Lymphoma Society Special Fellow, DFCI|
|2006–2009||Susan Komen Foundation Postdoctoral Fellowship, DFCI|
|2004–2006||Postdoctoral fellowship in the laboratory of David Pellman, Dana Farber Cancer Institute|
|2004||PhD in Cell and Developmental Biology, University of California Davis. Davis, CA|
|1996||MS in Cell Biology, Ewha Woman's University. Seoul, Korea|
|1994||BS in Biology, Ewha Woman's University. Seoul, Korea|
- Lee JK, Choi YL, Kwon M, Park PJ. Mechanisms and consequences of cancer genome instability: lessons from genome sequencing studies. Annual Review of Pathology.
- Kwon M. Using cell culture models of centrosome amplification to study centrosome clustering in cancer. Methods in Molecular Biology. (2016) In Press.
- Kwon M*, Bagonis M, Danuser G, Pellman D*. Direct microtubule-binding by Myosin-10 orients centrosomes towards retraction fibers and subcortical actin clouds. Dev
Cell. (2015) 34(3):323-37. *(corresponding authors)
- Lee D, Acharya S*, Kwon M*, Drane P, Guan Y, Adelmant G, Kalev P, Shah J, Pellman D, Marto JA, Chowdhury D. Dephosphorylation primes the recruitment of 53BP1 to
double-strand DNA breaks. Mol Cell. (2014) 54:512-25. *(equal contribution)
- Breuer M, Kolano A, Kwon M, Li CC, Tsai TF, Pellman
D, Brunet S, Verlhac MH. HURP permits MTOC sorting for robust meiotic
spindle bipolarity, similar to extra centrosome clustering in cancer
cells. J Cell Biol. (2010) Dec 27;191(7):1251-60.
- Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M,
Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJ,
Knapp S, Gray NS. Small-molecule kinase inhibitors provide insight into
Mps1 cell cycle function. Nat Chem Biol. (2010) May;6(5):359-68.
- Godinho SA*, Kwon M*, Pellman D.
Centrosomes and cancer: how cancer cells divide with too many
centrosomes.Cancer Metastasis Rev. (2009) Jun;28(1-2):85-98.
- Kwon M*,Godinho
SA*, Chandhok NS, Ganem NJ, Azioune A, Thery M, Pellman D.Mechanisms to
suppress multipolar divisions in cancer cells with extra centrosomes.
Genes Dev. (2008) Aug 15;22(16):2189-203.
- Kwon M, & Scholey JM. Spindle mechanics and dynamics during mitosis in Drosophila. Trends Cell Biol (2004), 14(4):194–205.
- Kwon M,
Morales-Mulia S, Brust-Mascher I, Rogers GC, Sharp DJ, & Scholey
JM. The chromokinesin, KLP3A, dives mitotic spindle pole separation
during prometaphase and anaphase and facilitates chromatid motility.
Mol Biol Cell (2004), 15(1):219–33.
- Brust-Mascher I, Civelekoglu-Scholey G, Kwon M,
Mogilner A, Scholey JM.Model for anaphase B: role of three mitotic
motors in a switch from poleward flux to spindle elongation. Proc Natl
Acad Sci U S A (2004) Nov 9;101(45):15938-43.
- Kwon, M.,
Seo, S., Chun, H., Chung, J.M., Chung, I.K., and Hur, K.C. Dual effect
of nerve growth factor on cell death of PC12 cells induced by serum
deprivation. Mol Cells (2002) 13(2):167-7.4
- Sharp DJ, Brown HM, Kwon M,
Rogers GC, Holland G, & Scholey JM. Functional coordination of
three mitotic motors in Drosophila embryos. Mol Biol Cell (2000),