Research Interest
My current research aims to characterize one molecular mechanism by which aneuploidy might promote genetic changes that drive tumorigenesis. While there is a broad agreement about the role played by chromosome breaks in activating oncogenes or inactivating tumor suppressors, the extent to which whole-chromosome aneuploidy might impact tumor progression is still debated. In collaboration with Dr. Karen Crasta, we are collecting evidence to support one mechanism by which whole chromosome aneuploidy can lead to DNA breaks, via mis-segregation of chromosomes into micronuclei, structures commonly observed in cancer cells.
Education
| 2009–present | Postdoctoral fellowship in the laboratory of David Pellman, Dana Farber Cancer Institute |
| 2003–2008 | PhD in Molecular Medicine, European School of Molecular Medicine, Italy |
Selected publications
- Carlucci A, Gedressi C, Lignitto L, Nezi L, Villa-Moruzzi E, Avvedimento EV, Gottesman ME, Garbi C, Feliciello A. Protein tyrosine phosphates PTPD1 regulates Fak autophosphorylation and cell migration. J Biol Chem. (2008)
- Nezi L, Rancati G, De Antoni A, Pasqualato S, Piatti S, Musacchio A. Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae. J Cell Biol. (2006)
- Mapelli M, Filipp FV, Rancati G, Massimiliano L, Nezi L, Stier G, Hagan RS, Confalonieri S, Piatti S, Sattler M, Musacchio A. Determinants of conformational dimerization of Mad2 and its inhibition by p31comet. EMBO J. (2006)
- Acquaviva F, De Biase I, Nezi L, Ruggiero G, Tatangelo F, Pisano C, Monticelli A, Garbi C, Acquaviva AM, Cocozza S. Extra-mitochondrial localization of frataxin and its association with IscU1 during enterocyte-like differentiation of the human colon adenocarcinoma cell line Caco-2. J Cell Sci. (2005)
- De Antoni A, Pearson CG, Cimini D, Canman JC, Sala V, Nezi L, Mapelli M, Sironi L, Faretta M, Salmon ED, Musacchio A. The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Current Biology (2005)
- De Felice B, Wilson RR, Mondola P, Matrone G, Damiano S, Garbi C, Nezi L, Su TT. Characterization of DIP1, a novel nuclear protein in Drosophila melanogaster.Biochem Biophys Res Commun. (2003)
- Nezi L, Greco D, Nitsch L, Garbi C. The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures Biol Chem. (2002)
