A. Thomas Look, M.D.
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Affiliation

Dana-Farber Cancer Institute

Vice Chair for Research

Education

B.S.E. | University of Michigan | Ann Arbor, Michigan | 1971

M.D. | University of Michigan | Ann Arbor, Michigan | 1975

Postdoctoral Training

  • 1975 | Intern in Pediatrics | University of Michigan | Ann Arbor, Michigan
  • 1976 | Resident in Pediatrics | University of Michigan | Ann Arbor, Michigan
  • 1977 | Fellow, Pediatric Hematology-Oncology | St. Jude Children's Research Hospital | Memphis, Tennessee
  • 1979 | Research Associate, Hematology?Oncology | St. Jude Children's Research Hospital | Memphis, Tennessee

Awards

  • 1987 | Allison Eberlein Award | Childhood Leukemia Research
  • 1994 | Adam Balinsky Memorial Lecturership | Hospital for Sick Children | Toronto, Canada
  • 1995 | Excellence in Pediatric Research | American Academy of Pediatrics
  • 1997 | William E. Hathaway Visiting Professorship | The Children's Hospital | Denver, Colorado
  • 1999 | Giulio J. D'Angio Lecturership | Children's Hospital of Philadelphia |Philadelphia, Pennsylvania
  • 2000 | Daniel Burton Endowment Fund Lectureship in Leukemia | The Hospital for Sick Children | Toronto, Canada
  • 2001 | Visiting Professorship, The Puerto Rican Society of Hematology and Medical Oncology | Fajardo, Puerto Rico
  • 2002 | Pediatric Cancer Research Foundation Memorial Lectureship | Newport Beach, California
  • 2003 | Visiting Professorship | University of New Mexico | Albuquerque, New Mexico
  • 2004 | Visiting Professorship | Shanghai Second Medical University | Shanghai, China
  • 2004 | Pediatric Oncology Lectureship | American Society of Clinical Oncology Meeting | New Orleans, LA
  • 2005 | Frank A. Oski Memorial Lectureship Award | ASPHO | Washington, DC
  • 2005 | Ian Peter Rennert Lectureship Award | Pediatric Oncology | Georgetown University, Washington, DC

Publications

  1. 2012
    1. Kinome-wide selectivity profiling of ATP-competitive mTOR (mammalian target of rapamycin) inhibitors and characterization of their binding kinetics.
      Liu Q, Kirubakaran S, Hur W, Niepel M, Westover K, Thoreen CC, Wang J, Ni J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, Kang SA, Zhao J, Look AT, Sorger PK, Sabatini DM, Gray NS.
      The Journal Of Biological Chemistry, 2012; PubMedID: 22223645.
  2. 2011
    1. Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb.
      Grabher C, Payne EM, Johnston AB, Bolli N, Lechman E, Dick JE, Kanki JP, Look AT.
      Leukemia, 2011; 25(3): 506-14. PubMedID: 21079614.
    1. mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues.
      Robinson BW, Germano G, Song Y, Abrams J, Scott M, Guariento I, Tiso N, Argenton F, Basso G, Rhodes J, Kanki JP, Look AT, Balice-Gordon RJ, Felix CA.
      Br. J. Haematol., 2011; 152(3): 307-21. PubMedID: 21155757.
    1. cpsf1 is required for definitive HSC survival in zebrafish.
      Bolli N, Payne EM, Rhodes J, Gjini E, Johnston AB, Guo F, Lee JS, Stewart RA, Kanki JP, Chen AT, Zhou Y, Zon LI, Look AT.
      Blood, 2011; 117(15): 3996-4007. PubMedID: 21330472.
    1. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
      Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W.
      Nature, 2011; 471(7336): 104-9. PubMedID: 21368833.
    1. Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.
      Li X, Sanda T, Look AT, Novina CD, von Boehmer H.
      J. Exp. Med., 2011; 208(4): 663-75. PubMedID: 21464222.
    1. Shared acquired genomic changes in zebrafish and human T-ALL.
      Rudner LA, Brown KH, Dobrinski KP, Bradley DF, Garcia MI, Smith AC, Downie JM, Meeker ND, Look AT, Downing JR, Gutierrez A, Mullighan CG, Schiffman JD, Lee C, Trede NS, Frazer JK.
      Oncogene, 2011; 30(41): 4289-96. PubMedID: 21552289.
    1. Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML.
      Payne EM, Bolli N, Rhodes J, Abdel-Wahab OI, Levine R, Hedvat CV, Stone R, Khanna-Gupta A, Sun H, Kanki JP, Gazda HT, Beggs AH, Cotter FE, Look AT.
      Blood, 2011; 118(4): 903-15. PubMedID: 21653321.
    1. Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia.
      Gutierrez A, Grebliunaite R, Feng H, Kozakewich E, Zhu S, Guo F, Payne E, Mansour M, Dahlberg SE, Neuberg DS, den Hertog J, Prochownik EV, Testa JR, Harris M, Kanki JP, Look AT.
      J. Exp. Med., 2011; 208(8): 1595-603. PubMedID: 21727187.
    1. NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis.
      Forrester AM, Grabher C, McBride ER, Boyd ER, Vigerstad MH, Edgar A, Kai FB, Da'as SI, Payne E, Look AT, Berman JN.
      Br. J. Haematol., 2011; 155(2): 167-81. PubMedID: 21810091.
    1. The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.
      Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter SS, Hunger SP, Sallan SE, Zha S, Alt FW, Downing JR, Mullighan CG, Look AT.
      Blood, 2011; 118(15): 4169-73. PubMedID: 21878675.
    1. p63 mediates an apoptotic response to pharmacological and disease-related ER stress in the developing epidermis.
      Pyati UJ, Gjini E, Carbonneau S, Lee JS, Guo F, Jette CA, Kelsell DP, Look AT.
      Dev. Cell, 2011; 21(3): 492-505. PubMedID: 21920315.
    1. Aberrant AKT activation drives well-differentiated liposarcoma.
      Gutierrez A, Snyder EL, Marino-Enriquez A, Zhang YX, Sioletic S, Kozakewich E, Grebliunaite R, Ou WB, Sicinska E, Raut CP, Demetri GD, Perez-Atayde AR, Wagner AJ, Fletcher JA, Fletcher CD, Look AT.
      Proc. Natl. Acad. Sci. U.S.A., 2011; 108(39): 16386-91. PubMedID: 21930930.
    1. Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish.
      Zhu C, Smith T, McNulty J, Rayla AL, Lakshmanan A, Siekmann AF, Buffardi M, Meng X, Shin J, Padmanabhan A, Cifuentes D, Giraldez AJ, Look AT, Epstein JA, Lawson ND, Wolfe SA.
      Development, 2011; 138(20): 4555-64. PubMedID: 21937602.
    1. Zebrafish as a model for the study of human cancer.
      Etchin J, Kanki JP, Look AT.
      Methods Cell Biol., 2011; 105: 309-37. PubMedID: 21951536.
    1. Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma.
      Mansour MR, Look AT.
      Cancer Cell, 2011; 20(5): 559-61. PubMedID: 22094251.
  3. 2010
    1. Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells.
      Okuya M, Kurosawa H, Kikuchi J, Furukawa Y, Matsui H, Aki D, Matsunaga T, Inukai T, Goto H, Altura RA, Sugita K, Arisaka O, Look AT, Inaba T.
      J. Biol. Chem., 2010; 285(3): 1850-60. PubMedID: 19887369.
    1. NOTCH2 links protein kinase C delta to the expression of CD23 in chronic lymphocytic leukaemia (CLL) cells.
      Hubmann R, Düchler M, Schnabl S, Hilgarth M, Demirtas D, Mitteregger D, Hölbl A, Vanura K, Le T, Look T, Schwarzmeier JD, Valent P, Jäger U, Shehata M.
      Br. J. Haematol., 2010; 148(6): 868-78. PubMedID: 19995395.
    1. Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia.
      Sanda T, Li X, Gutierrez A, Ahn Y, Neuberg DS, O'Neil J, Strack PR, Winter CG, Winter SS, Larson RS, von Boehmer H, Look AT.
      Blood, 2010; 115(9): 1735-45. PubMedID: 20007543.
    1. Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.
      Gutierrez A, Sanda T, Ma W, Zhang J, Grebliunaite R, Dahlberg S, Neuberg D, Protopopov A, Winter SS, Larson RS, Borowitz MJ, Silverman LB, Chin L, Hunger SP, Jamieson C, Sallan SE, Look AT.
      Blood, 2010; 115(14): 2845-51. PubMedID: 20124220.
    1. Specific induction of CD33 expression by E2A-HLF: the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor.
      Akahane K, Inukai T, Inaba T, Kurosawa H, Look AT, Kiyokawa N, Fujimoto J, Goto H, Endo M, Zhang X, Hirose K, Kuroda I, Honna H, Kagami K, Goi K, Nakazawa S, Sugita K.
      Leukemia, 2010; 24(4): 865-9. PubMedID: 20147975.
    1. Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish.
      Bolli N, Payne EM, Grabher C, Lee JS, Johnston AB, Falini B, Kanki JP, Look AT.
      Blood, 2010; 115(16): 3329-40. PubMedID: 20197555.
    1. SNP array analysis in hematologic malignancies: avoiding false discoveries.
      Heinrichs S, Li C, Look AT.
      Blood, 2010; 115(21): 4157-61. PubMedID: 20304806.
    1. Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation.
      Shao L, Sun Y, Zhang Z, Feng W, Gao Y, Cai Z, Wang ZZ, Look AT, Wu WS.
      Blood, 2010; 115(23): 4707-14. PubMedID: 20360471.
    1. Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis.
      Stewart RA, Sanda T, Widlund HR, Zhu S, Swanson KD, Hurley AD, Bentires-Alj M, Fisher DE, Kontaridis MI, Look AT, Neel BG.
      Dev. Cell, 2010; 18(5): 750-62. PubMedID: 20493809.
    1. Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
      Hirose K, Inukai T, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, Oram SH, Göttgens B, Kiyokawa N, Miyagawa Y, Okita H, Akahane K, Zhang X, Kuroda I, Honna H, Kagami K, Goi K, Kurosawa H, Look AT, Matsui H, Inaba T, Sugita K.
      Blood, 2010; 116(6): 962-70. PubMedID: 20519628.
    1. ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.
      Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look AT, Alt FW.
      J. Exp. Med., 2010; 207(7): 1369-80. PubMedID: 20566716.
    1. Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia.
      Gutierrez A, Dahlberg SE, Neuberg DS, Zhang J, Grebliunaite R, Sanda T, Protopopov A, Tosello V, Kutok J, Larson RS, Borowitz MJ, Loh ML, Ferrando AA, Winter SS, Mullighan CG, Silverman LB, Chin L, Hunger SP, Sallan SE, Look AT.
      J. Clin. Oncol., 2010; 28(24): 3816-23. PubMedID: 20644084.
    1. Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene.
      Lee JS, Padmanabhan A, Shin J, Zhu S, Guo F, Kanki JP, Epstein JA, Look AT.
      Hum. Mol. Genet., 2010; 19(23): 4643-53. PubMedID: 20858602.
    1. Outcome after reduced chemotherapy for intermediate-risk neuroblastoma.
      Baker DL, Schmidt ML, Cohn SL, Maris JM, London WB, Buxton A, Stram D, Castleberry RP, Shimada H, Sandler A, Shamberger RC, Look AT, Reynolds CP, Seeger RC, Matthay KK.
      N. Engl. J. Med., 2010; 363(14): 1313-23. PubMedID: 20879880.
    1. T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.
      Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT.
      Cancer Cell, 2010; 18(4): 353-66. PubMedID: 20951945.
    1. Studying peripheral sympathetic nervous system development and neuroblastoma in zebrafish.
      Stewart RA, Lee JS, Lachnit M, Look AT, Kanki JP, Henion PD.
      Methods Cell Biol., 2010; 100: 127-52. PubMedID: 21111216.
  4. 2009
    1. Construction and application of a zebrafish array comparative genomic hybridization platform.
      Freeman JL, Ceol C, Feng H, Langenau DM, Belair C, Stern HM, Song A, Paw BH, Look AT, Zhou Y, Zon LI, Lee C.
      Genes Chromosomes Cancer, 2009; 48(2): 155-70. PubMedID: 18973135.
    1. Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24.
      Walters KB, Dodd ME, Mathias JR, Gallagher AJ, Bennin DA, Rhodes J, Kanki JP, Look AT, Grinblat Y, Huttenlocher A.
      Dev. Dyn., 2009; 238(1): 86-99. PubMedID: 19097072.
    1. Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.
      Webb TR, Slavish J, George RE, Look AT, Xue L, Jiang Q, Cui X, Rentrop WB, Morris SW.
      Expert Rev Anticancer Ther, 2009; 9(3): 331-56. PubMedID: 19275511.
    1. Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.
      Rao SS, O'Neil J, Liberator CD, Hardwick JS, Dai X, Zhang T, Tyminski E, Yuan J, Kohl NE, Richon VM, Van der Ploeg LH, Carroll PM, Draetta GF, Look AT, Strack PR, Winter CG.
      Cancer Res., 2009; 69(7): 3060-8. PubMedID: 19318552.
    1. CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors.
      Chen CC, Kennedy RD, Sidi S, Look AT, D'Andrea A.
      Mol. Cancer, 2009; 8: 24. PubMedID: 19371427.
    1. Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics.
      Heinrichs S, Kulkarni RV, Bueso-Ramos CE, Levine RL, Loh ML, Li C, Neuberg D, Kornblau SM, Issa JP, Gilliland DG, Garcia-Manero G, Kantarjian HM, Estey EH, Look AT.
      Leukemia, 2009; 23(9): 1605-13. PubMedID: 19387468.
    1. Comparison of primary neuroblastoma tumors and derivative early-passage cell lines using genome-wide single nucleotide polymorphism array analysis.
      Volchenboum SL, Li C, Li S, Attiyeh EF, Reynolds CP, Maris JM, Look AT, George RE.
      Cancer Res., 2009; 69(10): 4143-9. PubMedID: 19435921.
    1. High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.
      Gutierrez A, Sanda T, Grebliunaite R, Carracedo A, Salmena L, Ahn Y, Dahlberg S, Neuberg D, Moreau LA, Winter SS, Larson R, Zhang J, Protopopov A, Chin L, Pandolfi PP, Silverman LB, Hunger SP, Sallan SE, Look AT.
      Blood, 2009; 114(3): 647-50. PubMedID: 19458356.
    1. Zebrafish modelling of leukaemias.
      Payne E, Look T.
      Br. J. Haematol., 2009; 146(3): 247-56. PubMedID: 19466976.
    1. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish.
      Niethammer P, Grabher C, Look AT, Mitchison TJ.
      Nature, 2009; 459(7249): 996-9. PubMedID: 19494811.
    1. Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG.
      Okamatsu C, London WB, Naranjo A, Hogarty MD, Gastier-Foster JM, Look AT, LaQuaglia M, Maris JM, Cohn SL, Matthay KK, Seeger RC, Saji T, Shimada H.
      Pediatr Blood Cancer, 2009; 53(4): 563-9. PubMedID: 19530234.
    1. The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish.
      Dodd ME, Hatzold J, Mathias JR, Walters KB, Bennin DA, Rhodes J, Kanki JP, Look AT, Hammerschmidt M, Huttenlocher A.
      Development, 2009; 136(15): 2591-600. PubMedID: 19570844.
    1. Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.
      Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radtke I, Downing JR, Fleming MD, MacConaill LE, Amatruda JF, Gutierrez A, Galinsky I, Stone RM, Ross EA, Pellman DS, Kanki JP, Look AT.
      Mol. Cell. Biol., 2009; 29(21): 5911-22. PubMedID: 19704007.
    1. Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia.
      Tammam J, Ware C, Efferson C, O'Neil J, Rao S, Qu X, Gorenstein J, Angagaw M, Kim H, Kenific C, Kunii K, Leach KJ, Nikov G, Zhao J, Dai X, Hardwick J, Scott M, Winter C, Bristow L, Elbi C, Reilly JF, Look T, Draetta G, Van der Ploeg L, Kohl NE, Strack PR, Majumder PK.
      Br. J. Pharmacol., 2009; 158(5): 1183-95. PubMedID: 19775282.
    1. Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI.
      Padmanabhan A, Lee JS, Ismat FA, Lu MM, Lawson ND, Kanki JP, Look AT, Epstein JA.
      Proc. Natl. Acad. Sci. U.S.A., 2009; 106(52): 22305-10. PubMedID: 19966217.
    1. Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo.
      Kamizono S, Duncan GS, Seidel MG, Morimoto A, Hamada K, Grosveld G, Akashi K, Lind EF, Haight JP, Ohashi PS, Look AT, Mak TW.
      J. Exp. Med., 2009; 206(13): 2977-86. PubMedID: 19995955.
  5. 2008
    1. SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients.
      Swanson KD, Winter JM, Reis M, Bentires-Alj M, Greulich H, Grewal R, Hruban RH, Yeo CJ, Yassin Y, Iartchouk O, Montgomery K, Whitman SP, Caligiuri MA, Loh ML, Gilliland DG, Look AT, Kucherlapati R, Kern SE, Meyerson M, Neel BG.
      Genes Chromosomes Cancer, 2008; 47(3): 253-9. PubMedID: 18064648.
    1. Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group.
      Schneiderman J, London WB, Brodeur GM, Castleberry RP, Look AT, Cohn SL.
      J. Clin. Oncol., 2008; 26(6): 913-8. PubMedID: 18281664.
    1. Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.
      Kim WJ, Okimoto RA, Purton LE, Goodwin M, Haserlat SM, Dayyani F, Sweetser DA, McClatchey AI, Bernard OA, Look AT, Bell DW, Scadden DT, Haber DA.
      Blood, 2008; 111(9): 4716-22. PubMedID: 18299447.
    1. The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.
      Schlisio S, Kenchappa RS, Vredeveld LC, George RE, Stewart R, Greulich H, Shahriari K, Nguyen NV, Pigny P, Dahia PL, Pomeroy SL, Maris JM, Look AT, Meyerson M, Peeper DS, Carter BD, Kaelin WG.
      Genes Dev., 2008; 22(7): 884-93. PubMedID: 18334619.
    1. Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish.
      Langenau DM, Keefe MD, Storer NY, Jette CA, Smith AC, Ceol CJ, Bourque C, Look AT, Zon LI.
      Oncogene, 2008; 27(30): 4242-8. PubMedID: 18345029.
    1. Acute lymphoblastic leukaemia.
      Pui CH, Robison LL, Look AT.
      Lancet, 2008; 371(9617): 1030-43. PubMedID: 18358930.
    1. BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals.
      Jette CA, Flanagan AM, Ryan J, Pyati UJ, Carbonneau S, Stewart RA, Langenau DM, Look AT, Letai A.
      Cell Death Differ., 2008; 15(6): 1063-72. PubMedID: 18404156.
    1. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.
      Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF, Kanki JP, Green DR, D'Andrea AA, Look AT.
      Cell, 2008; 133(5): 864-77. PubMedID: 18510930.
    1. In vivo interstitial migration of primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling in response to acute injury.
      Zhang Y, Bai XT, Zhu KY, Jin Y, Deng M, Le HY, Fu YF, Chen Y, Zhu J, Look AT, Kanki J, Chen Z, Chen SJ, Liu TX.
      J. Immunol., 2008; 181(3): 2155-64. PubMedID: 18641354.
    1. Activating mutations in ALK provide a therapeutic target in neuroblastoma.
      George RE, Sanda T, Hanna M, Fröhling S, Luther W, Zhang J, Ahn Y, Zhou W, London WB, McGrady P, Xue L, Zozulya S, Gregor VE, Webb TR, Gray NS, Gilliland DG, Diller L, Greulich H, Morris SW, Meyerson M, Look AT.
      Nature, 2008; 455(7215): 975-8. PubMedID: 18923525.
  6. 2007
    1. Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.
      Liu TX, Becker MW, Jelinek J, Wu WS, Deng M, Mikhalkevich N, Hsu K, Bloomfield CD, Stone RM, DeAngelo DJ, Galinsky IA, Issa JP, Clarke MF, Look AT.
      Nat. Med., 2007; 13(1): 78-83. PubMedID: 17159988.
    1. Zebrafish as a powerful vertebrate model system for in vivo studies of cell death.
      Pyati UJ, Look AT, Hammerschmidt M.
      Semin. Cancer Biol., 2007; 17(2): 154-65. PubMedID: 17210257.
    1. NOTCH1-induced T-cell leukemia in transgenic zebrafish.
      Chen J, Jette C, Kanki JP, Aster JC, Look AT, Griffin JD.
      Leukemia, 2007; 21(3): 462-71. PubMedID: 17252014.
    1. Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish.
      Liu TX, Rhodes J, Deng M, Hsu K, Radomska HS, Kanki JP, Tenen DG, Look AT.
      Exp. Hematol., 2007; 35(2): 230-9. PubMedID: 17258072.
    1. Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.
      Lewis HD, Leveridge M, Strack PR, Haldon CD, O'neil J, Kim H, Madin A, Hannam JC, Look AT, Kohl N, Draetta G, Harrison T, Kerby JA, Shearman MS, Beher D.
      Chem. Biol., 2007; 14(2): 209-19. PubMedID: 17317574.
    1. Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation.
      Guo Z, Dose M, Kovalovsky D, Chang R, O'Neil J, Look AT, von Boehmer H, Khazaie K, Gounari F.
      Blood, 2007; 109(12): 5463-72. PubMedID: 17317856.
    1. Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays.
      George RE, Attiyeh EF, Li S, Moreau LA, Neuberg D, Li C, Fox EA, Meyerson M, Diller L, Fortina P, Look AT, Maris JM.
      PLoS ONE, 2007; 2(2): e255. PubMedID: 17327916.
    1. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.
      Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, Wiedemeyer R, Kabbarah O, Nogueira C, Histen G, Aster J, Mansour M, Duke V, Foroni L, Fielding AK, Goldstone AH, Rowe JM, Wang YA, Look AT, Stratton MR, Chin L, Futreal PA, DePinho RA.
      Nature, 2007; 447(7147): 966-71. PubMedID: 17515920.
    1. Targeting transcription factors in acute leukemia in children.
      Berman JN, Look AT.
      Curr Drug Targets, 2007; 8(6): 727-37. PubMedID: 17584028.
    1. Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish.
      Feng H, Langenau DM, Madge JA, Quinkertz A, Gutierrez A, Neuberg DS, Kanki JP, Look AT.
      Br. J. Haematol., 2007; 138(2): 169-75. PubMedID: 17593023.
    1. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.
      O'Neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C, Hardwick J, Welcker M, Meijerink JP, Pieters R, Draetta G, Sears R, Clurman BE, Look AT.
      J. Exp. Med., 2007; 204(8): 1813-24. PubMedID: 17646409.
    1. Identification of structural aberrations in cancer by SNP array analysis.
      Heinrichs S, Look AT.
      Genome Biol., 2007; 8(7): 219. PubMedID: 17666119.
    1. A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors.
      Smolen GA, Schott BJ, Stewart RA, Diederichs S, Muir B, Provencher HL, Look AT, Sgroi DC, Peterson RT, Haber DA.
      Genes Dev., 2007; 21(17): 2131-6. PubMedID: 17704304.
    1. Live imaging of chronic inflammation caused by mutation of zebrafish Hai1.
      Mathias JR, Dodd ME, Walters KB, Rhodes J, Kanki JP, Look AT, Huttenlocher A.
      J. Cell. Sci., 2007; 120: 3372-83. PubMedID: 17881499.
    1. Mechanisms of transcription factor deregulation in lymphoid cell transformation.
      O'Neil J, Look AT.
      Oncogene, 2007; 26(47): 6838-49. PubMedID: 17934490.
    1. NOTCH and PI3K-AKT pathways intertwined.
      Gutierrez A, Look AT.
      Cancer Cell, 2007; 12(5): 411-3. PubMedID: 17996644.
    1. Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell.
      Hansford LM, McKee AE, Zhang L, George RE, Gerstle JT, Thorner PS, Smith KM, Look AT, Yeger H, Miller FD, Irwin MS, Thiele CJ, Kaplan DR.
      Cancer Res., 2007; 67(23): 11234-43. PubMedID: 18056449.
    1. Alu elements mediate MYB gene tandem duplication in human T-ALL.
      O'Neil J, Tchinda J, Gutierrez A, Moreau L, Maser RS, Wong KK, Li W, McKenna K, Liu XS, Feng B, Neuberg D, Silverman L, DeAngelo DJ, Kutok JL, Rothstein R, DePinho RA, Chin L, Lee C, Look AT.
      J. Exp. Med., 2007; 204(13): 3059-66. PubMedID: 18070937.
  7. 2006
    1. Activating Notch1 mutations in mouse models of T-ALL.
      O'Neil J, Calvo J, McKenna K, Krishnamoorthy V, Aster JC, Bassing CH, Alt FW, Kelliher M, Look AT.
      Blood, 2006; 107(2): 781-5. PubMedID: 16166587.
    1. Fishing for cancer models.
      Grabher C, Look AT.
      Nat. Biotechnol., 2006; 24(1): 45-6. PubMedID: 16404393.
    1. Zebrafish foxd3 is selectively required for neural crest specification, migration and survival.
      Stewart RA, Arduini BL, Berghmans S, George RE, Kanki JP, Henion PD, Look AT.
      Dev. Biol., 2006; 292(1): 174-88. PubMedID: 16499899.
    1. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia.
      Grabher C, von Boehmer H, Look AT.
      Nat. Rev. Cancer, 2006; 6(5): 347-59. PubMedID: 16612405.
    1. Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia.
      Palomero T, Odom DT, O'Neil J, Ferrando AA, Margolin A, Neuberg DS, Winter SS, Larson RS, Li W, Liu XS, Young RA, Look AT.
      Blood, 2006; 108(3): 986-92. PubMedID: 16621969.
    1. A new recurrent 9q34 duplication in pediatric T-cell acute lymphoblastic leukemia.
      van Vlierberghe P, Meijerink JP, Lee C, Ferrando AA, Look AT, van Wering ER, Beverloo HB, Aster JC, Pieters R.
      Leukemia, 2006; 20(7): 1245-53. PubMedID: 16673019.
    1. Identification of additional cytogenetic and molecular genetic abnormalities in acute myeloid leukaemia with t(8;21)/AML1-ETO.
      Kuchenbauer F, Schnittger S, Look T, Gilliland G, Tenen D, Haferlach T, Hiddemann W, Buske C, Schoch C.
      Br. J. Haematol., 2006; 134(6): 616-9. PubMedID: 16938118.
    1. Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish.
      Mathias JR, Perrin BJ, Liu TX, Kanki J, Look AT, Huttenlocher A.
      J. Leukoc. Biol., 2006; 80(6): 1281-8. PubMedID: 16963624.
    1. Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias.
      Palomero T, McKenna K, O-Neil J, Galinsky I, Stone R, Suzukawa K, Stiakaki E, Kalmanti M, Fox EA, Caligiuri MA, Aster JC, Look AT, Ferrando AA.
      Leukemia, 2006; 20(11): 1963-6. PubMedID: 17008890.
    1. Does MYCN amplification manifested as homogeneously staining regions at diagnosis predict a worse outcome in children with neuroblastoma? A Children's Oncology Group study.
      Moreau LA, McGrady P, London WB, Shimada H, Cohn SL, Maris JM, Diller L, Look AT, George RE.
      Clin. Cancer Res., 2006; 12(19): 5693-7. PubMedID: 17020972.
    1. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.
      Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando AA.
      Proc. Natl. Acad. Sci. U.S.A., 2006; 103(48): 18261-6. PubMedID: 17114293.
  8. 2005
    1. Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish.
      Langenau DM, Jette C, Berghmans S, Palomero T, Kanki JP, Kutok JL, Look AT.
      Blood, 2005; 105(8): 3278-85. PubMedID: 15618471.
    1. Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish.
      Rhodes J, Hagen A, Hsu K, Deng M, Liu TX, Look AT, Kanki JP.
      Dev. Cell, 2005; 8(1): 97-108. PubMedID: 15621533.
    1. tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.
      Berghmans S, Murphey RD, Wienholds E, Neuberg D, Kutok JL, Fletcher CD, Morris JP, Liu TX, Schulte-Merker S, Kanki JP, Plasterk R, Zon LI, Look AT.
      Proc. Natl. Acad. Sci. U.S.A., 2005; 102(2): 407-12. PubMedID: 15630097.
    1. TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors.
      Inukai T, Inaba T, Dang J, Kuribara R, Ozawa K, Miyajima A, Wu W, Look AT, Arinobu Y, Iwasaki H, Akashi K, Kagami K, Goi K, Sugita K, Nakazawa S.
      Blood, 2005; 105(11): 4437-44. PubMedID: 15665112.
    1. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.
      Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD, Berghmans S, Mayhall EA, Traver D, Fletcher CD, Aster JC, Granter SR, Look AT, Lee C, Fisher DE, Zon LI.
      Curr. Biol., 2005; 15(3): 249-54. PubMedID: 15694309.
    1. Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts and treatment outcome in children with B-progenitor-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
      Whitehead VM, Shuster JJ, Vuchich MJ, Mahoney DH, Lauer SJ, Payment C, Koch PA, Cooley LD, Look AT, Pullen DJ, Camitta B.
      Leukemia, 2005; 19(4): 533-6. PubMedID: 15716987.
    1. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.
      Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, von Boehmer H, Aifantis I.
      J. Exp. Med., 2005; 201(4): 603-14. PubMedID: 15728238.
    1. Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia.
      Langenau DM, Feng H, Berghmans S, Kanki JP, Kutok JL, Look AT.
      Proc. Natl. Acad. Sci. U.S.A., 2005; 102(17): 6068-73. PubMedID: 15827121.
    1. CD34+ cell selection is required to assess HOXA9 expression levels in patients with myelodysplastic syndrome.
      Heinrichs S, Berman JN, Ortiz TM, Kornblau SM, Neuberg DS, Estey EH, Look AT.
      Br. J. Haematol., 2005; 130(1): 83-6. PubMedID: 15982348.
    1. The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia.
      Levine RL, Loriaux M, Huntly BJ, Loh ML, Beran M, Stoffregen E, Berger R, Clark JJ, Willis SG, Nguyen KT, Flores NJ, Estey E, Gattermann N, Armstrong S, Look AT, Griffin JD, Bernard OA, Heinrich MC, Gilliland DG, Druker B, Deininger MW.
      Blood, 2005; 106(10): 3377-9. PubMedID: 16081687.
    1. Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology Group study.
      George RE, London WB, Cohn SL, Maris JM, Kretschmar C, Diller L, Brodeur GM, Castleberry RP, Look AT.
      J. Clin. Oncol., 2005; 23(27): 6466-73. PubMedID: 16116152.
    1. Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children's Oncology Group.
      London WB, Castleberry RP, Matthay KK, Look AT, Seeger RC, Shimada H, Thorner P, Brodeur G, Maris JM, Reynolds CP, Cohn SL.
      J. Clin. Oncol., 2005; 23(27): 6459-65. PubMedID: 16116153.
    1. Making waves in cancer research: new models in the zebrafish.
      Berghmans S, Jette C, Langenau D, Hsu K, Stewart R, Look T, Kanki JP.
      BioTechniques, 2005; 39(2): 227-37. PubMedID: 16116796.
    1. State of the Art and Future Needs in Cytogenetic/Molecular Genetics/Arrays in childhood lymphoma: summary report of workshop at the First International Symposium on childhood and adolescent non-Hodgkin lymphoma, April 9, 2003, New York City, NY.
      Heerema NA, Bernheim A, Lim MS, Look AT, Pasqualucci L, Raetz E, Sanger WG, Cairo MS.
      Pediatr Blood Cancer, 2005; 45(5): 616-22. PubMedID: 16127683.
    1. Zebrafish as a model for myelopoiesis during embryogenesis.
      Berman JN, Kanki JP, Look AT.
      Exp. Hematol., 2005; 33(9): 997-1006. PubMedID: 16140147.
    1. Molecular genetics of acute lymphoblastic leukemia.
      Armstrong SA, Look AT.
      J. Clin. Oncol., 2005; 23(26): 6306-15. PubMedID: 16155013.
    1. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma.
      Wu WS, Heinrichs S, Xu D, Garrison SP, Zambetti GP, Adams JM, Look AT.
      Cell, 2005; 123(4): 641-53. PubMedID: 16286009.
    1. Molecular Pathogenesis of MDS.
      Look AT.
      Hematology Am Soc Hematol Educ Program, 2005; : 156-60. PubMedID: 16304374.
    1. Chromosome 1p and 11q deletions and outcome in neuroblastoma.
      Attiyeh EF, London WB, Mossé YP, Wang Q, Winter C, Khazi D, McGrady PW, Seeger RC, Look AT, Shimada H, Brodeur GM, Cohn SL, Matthay KK, Maris JM.
      N. Engl. J. Med., 2005; 353(21): 2243-53. PubMedID: 16306521.
    1. Outcomes of children with intermediate-risk neuroblastoma after treatment stratified by MYCN status and tumor cell ploidy.
      Bagatell R, Rumcheva P, London WB, Cohn SL, Look AT, Brodeur GM, Frantz C, Joshi V, Thorner P, Rao PV, Castleberry R, Bowman LC.
      J. Clin. Oncol., 2005; 23(34): 8819-27. PubMedID: 16314642.
    1. Small molecules thwart crash and burn.
      Sidi S, Look AT.
      Nat. Chem. Biol., 2005; 1(7): 351-3. PubMedID: 16370367.
    1. Investigator profile. An interview with A. Thomas Look, M.D. Interview by Vicki Glaser.
      Look AT.
      Zebrafish, 2005; 2(4): 231-6. PubMedID: 18248181.
  9. 2004
    1. Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia.
      Ferrando AA, Herblot S, Palomero T, Hansen M, Hoang T, Fox EA, Look AT.
      Blood, 2004; 103(5): 1909-11. PubMedID: 14604958.
    1. IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.
      Barata JT, Boussiotis VA, Yunes JA, Ferrando AA, Moreau LA, Veiga JP, Sallan SE, Look AT, Nadler LM, Cardoso AA.
      Blood, 2004; 103(5): 1891-900. PubMedID: 14615384.
    1. Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia.
      Ferrando AA, Neuberg DS, Dodge RK, Paietta E, Larson RA, Wiernik PH, Rowe JM, Caligiuri MA, Bloomfield CD, Look AT.
      Lancet, 2004; 363(9408): 535-6. PubMedID: 14975618.
    1. The pu.1 promoter drives myeloid gene expression in zebrafish.
      Hsu K, Traver D, Kutok JL, Hagen A, Liu TX, Paw BH, Rhodes J, Berman JN, Zon LI, Kanki JP, Look AT.
      Blood, 2004; 104(5): 1291-7. PubMedID: 14996705.
    1. Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias.
      Paietta E, Ferrando AA, Neuberg D, Bennett JM, Racevskis J, Lazarus H, Dewald G, Rowe JM, Wiernik PH, Tallman MS, Look AT.
      Blood, 2004; 104(2): 558-60. PubMedID: 15044257.
    1. Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein.
      Matsunaga T, Inaba T, Matsui H, Okuya M, Miyajima A, Inukai T, Funabiki T, Endo M, Look AT, Kurosawa H.
      Blood, 2004; 103(8): 3185-91. PubMedID: 15070701.
    1. The use of zebrafish to understand immunity.
      Trede NS, Langenau DM, Traver D, Look AT, Zon LI.
      Immunity, 2004; 20(4): 367-79. PubMedID: 15084267.
    1. In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.
      Langenau DM, Ferrando AA, Traver D, Kutok JL, Hezel JP, Kanki JP, Zon LI, Look AT, Trede NS.
      Proc. Natl. Acad. Sci. U.S.A., 2004; 101(19): 7369-74. PubMedID: 15123839.
    1. Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation.
      Traver D, Winzeler A, Stern HM, Mayhall EA, Langenau DM, Kutok JL, Look AT, Zon LI.
      Blood, 2004; 104(5): 1298-305. PubMedID: 15142873.
    1. Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia.
      Graux C, Cools J, Melotte C, Quentmeier H, Ferrando A, Levine R, Vermeesch JR, Stul M, Dutta B, Boeckx N, Bosly A, Heimann P, Uyttebroeck A, Mentens N, Somers R, MacLeod RA, Drexler HG, Look AT, Gilliland DG, Michaux L, Vandenberghe P, Wlodarska I, Marynen P, Hagemeijer A.
      Nat. Genet., 2004; 36(10): 1084-9. PubMedID: 15361874.
    1. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
      Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC.
      Science, 2004; 306(5694): 269-71. PubMedID: 15472075.
    1. Targeted expression of human MYCN selectively causes pancreatic neuroendocrine tumors in transgenic zebrafish.
      Yang HW, Kutok JL, Lee NH, Piao HY, Fletcher CD, Kanki JP, Look AT.
      Cancer Res., 2004; 64(20): 7256-62. PubMedID: 15492244.
    1. Hematopoietic gene expression profile in zebrafish kidney marrow.
      Song HD, Sun XJ, Deng M, Zhang GW, Zhou Y, Wu XY, Sheng Y, Chen Y, Ruan Z, Jiang CL, Fan HY, Zon LI, Kanki JP, Liu TX, Look AT, Chen Z.
      Proc. Natl. Acad. Sci. U.S.A., 2004; 101(46): 16240-5. PubMedID: 15520368.
    1. Development of the peripheral sympathetic nervous system in zebrafish.
      Stewart RA, Look AT, Kanki JP, Henion PD.
      Methods Cell Biol., 2004; 76: 237-60. PubMedID: 15602879.
    1. Lessons from transgenic zebrafish expressing the green fluorescent protein (GFP) in the myeloid lineage.
      Hsu K, Look AT, Kanki JP.
      Methods Cell Biol., 2004; 77: 333-47. PubMedID: 15602920.
    1. Zebrafish sperm cryopreservation.
      Berghmans S, Morris JP, Kanki JP, Look AT.
      Methods Cell Biol., 2004; 77: 645-59. PubMedID: 15602936.
    1. DNA microarrays in the diagnosis and management of acute lymphoblastic leukemia.
      Ferrando AA, Look AT.
      Int. J. Hematol., 2004; 80(5): 395-400. PubMedID: 15646649.
    1. Molecular pathways in T-cell acute lympho-blastic leukemia: ramifications for therapy.
      Look AT.
      Clin Adv Hematol Oncol, 2004; 2(12): 779-80. PubMedID: 16166953.
  10. 2003
    1. Myc-induced T cell leukemia in transgenic zebrafish.
      Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, Look AT.
      Science, 2003; 299(5608): 887-90. PubMedID: 12574629.
    1. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.
      Ferrando AA, Armstrong SA, Neuberg DS, Sallan SE, Silverman LB, Korsmeyer SJ, Look AT.
      Blood, 2003; 102(1): 262-8. PubMedID: 12637319.
    1. Turning on a dimer: new insights into MLL chimeras.
      Hsu K, Look AT.
      Cancer Cell, 2003; 4(2): 81-3. PubMedID: 12957280.
    1. Gene expression profiling in T-cell acute lymphoblastic leukemia.
      Ferrando AA, Look AT.
      Semin. Hematol., 2003; 40(4): 274-80. PubMedID: 14582078.
    1. Zebrafish as a model organism for blood diseases.
      Berman J, Hsu K, Look AT.
      Br. J. Haematol., 2003; 123(4): 568-76. PubMedID: 14616958.
    1. Zebrafish sperm cryopreservation with N,N-dimethylacetamide.
      Morris JP, Berghmans S, Zahrieh D, Neuberg DS, Kanki JP, Look AT.
      BioTechniques, 2003; 35(5): 956-8, 960, 962 passim. PubMedID: 14628669.
    1. Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis.
      Liu TX, Howlett NG, Deng M, Langenau DM, Hsu K, Rhodes J, Kanki JP, D'Andrea AD, Look AT.
      Dev. Cell, 2003; 5(6): 903-14. PubMedID: 14667412.
  11. 2002
    1. Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies.
      Liu TX, Zhou Y, Kanki JP, Deng M, Rhodes J, Yang HW, Sheng XM, Zon LI, Look AT.
      Proc. Natl. Acad. Sci. U.S.A., 2002; 99(9): 6136-41. PubMedID: 11983906.
    1. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.
      Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC, Behm FG, Pui CH, Downing JR, Gilliland DG, Lander ES, Golub TR, Look AT.
      Cancer Cell, 2002; 1(1): 75-87. PubMedID: 12086890.
    1. A leukemogenic twist for GATA1.
      Look AT.
      Nat. Genet., 2002; 32(1): 83-4. PubMedID: 12172549.
    1. Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio).
      Langenau DM, Palomero T, Kanki JP, Ferrando AA, Zhou Y, Zon LI, Look AT.
      Mech. Dev., 2002; 117(1): 243-8. PubMedID: 12204264.
    1. Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo.
      Inoue A, Seidel MG, Wu W, Kamizono S, Ferrando AA, Bronson RT, Iwasaki H, Akashi K, Morimoto A, Hitzler JK, Pestina TI, Jackson CW, Tanaka R, Chong MJ, McKinnon PJ, Inukai T, Grosveld GC, Look AT.
      Cancer Cell, 2002; 2(4): 279-88. PubMedID: 12398892.
    1. No evidence for the presence of an imprinted neuroblastoma suppressor gene within chromosome sub-band 1p36.3.
      Hogarty MD, Winter CL, Liu X, Guo C, White PS, Look AT, Brodeur GM, Maris JM.
      Cancer Res., 2002; 62(22): 6481-4. PubMedID: 12438240.
  12. 2001
    1. Residential pesticide exposure and neuroblastoma.
      Daniels JL, Olshan AF, Teschke K, Hertz-Picciotto I, Savitz DA, Blatt J, Bondy ML, Neglia JP, Pollock BH, Cohn SL, Look AT, Seeger RC, Castleberry RP.
      Epidemiology, 2001; 12(1): 20-7. PubMedID: 11138814.
    1. Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors.
      Shinjyo T, Kuribara R, Inukai T, Hosoi H, Kinoshita T, Miyajima A, Houghton PJ, Look AT, Ozawa K, Inaba T.
      Mol. Cell. Biol., 2001; 21(3): 854-64. PubMedID: 11154272.
    1. Detection of MYCN gene amplification in neuroblastoma by fluorescence in situ hybridization: a pediatric oncology group study.
      Mathew P, Valentine MB, Bowman LC, Rowe ST, Nash MB, Valentine VA, Cohn SL, Castleberry RP, Brodeur GM, Look AT.
      Neoplasia, 2001; 3(2): 105-9. PubMedID: 11420745.
    1. The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
      Whitehead VM, Payment C, Cooley L, Lauer SJ, Mahoney DH, Shuster JJ, Vuchich MJ, Bernstein ML, Look AT, Pullen DJ, Camitta B.
      Leukemia, 2001; 15(7): 1081-8. PubMedID: 11455977.
    1. Biological aspects of neuroblastomas identified by mass screening in Quebec.
      Brodeur GM, Look AT, Shimada H, Hamilton VM, Maris JM, Hann HW, Leclerc JM, Bernstein M, Brisson LC, Brossard J, Lemieux B, Tuchman M, Woods WG.
      Med. Pediatr. Oncol., 2001; 36(1): 157-9. PubMedID: 11464873.
    1. Myelopoiesis in the zebrafish, Danio rerio.
      Bennett CM, Kanki JP, Rhodes J, Liu TX, Paw BH, Kieran MW, Langenau DM, Delahaye-Brown A, Zon LI, Fleming MD, Look AT.
      Blood, 2001; 98(3): 643-51. PubMedID: 11468162.
    1. The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1.
      Dang J, Inukai T, Kurosawa H, Goi K, Inaba T, Lenny NT, Downing JR, Stifani S, Look AT.
      Mol. Cell. Biol., 2001; 21(17): 5935-45. PubMedID: 11486032.
    1. Zebrafish myelopoiesis and blood cell development.
      Hsu K, Kanki JP, Look AT.
      Curr. Opin. Hematol., 2001; 8(4): 245-51. PubMedID: 11561163.
    1. E2A-HLF usurps control of evolutionarily conserved survival pathways.
      Seidel MG, Look AT.
      Oncogene, 2001; 20(40): 5718-25. PubMedID: 11607821.
  13. 2000
    1. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN.
      Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm FG, Look AT, Lahti JM, Kidd VJ.
      Nat. Med., 2000; 6(5): 529-35. PubMedID: 10802708.
    1. Natural history and biology of stage A neuroblastoma: a Pediatric Oncology Group Study.
      Alvarado CS, London WB, Look AT, Brodeur GM, Altmiller DH, Thorner PS, Joshi VV, Rowe ST, Nash MB, Smith EI, Castleberry RP, Cohn SL.
      J. Pediatr. Hematol. Oncol., 2000; 22(3): 197-205. PubMedID: 10864050.
    1. Reduced or absent expression and codon 201Gly/Arg polymorphism of DCC gene in rhabdomyosarcoma and Ewing's sarcoma/PNET family.
      Choi SH, Kong XT, Taki T, Tsuchida Y, Kawaguchi H, Kato H, Hanada R, Look AT, Hayashi Y.
      Int. J. Mol. Med., 2000; 6(4): 463-7. PubMedID: 10998440.
    1. Parental smoking and alcohol consumption and risk of neuroblastoma.
      Yang Q, Olshan AF, Bondy ML, Shah NR, Pollock BH, Seeger RC, Look AT, Cohn SL.
      Cancer Epidemiol. Biomarkers Prev., 2000; 9(9): 967-72. PubMedID: 11008916.
    1. Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia.
      Ferrando AA, Look AT.
      Semin. Hematol., 2000; 37(4): 381-95. PubMedID: 11071360.
  14. 1999
    1. Two candidate downstream target genes for E2A-HLF.
      Kurosawa H, Goi K, Inukai T, Inaba T, Chang KS, Shinjyo T, Rakestraw KM, Naeve CW, Look AT.
      Blood, 1999; 93(1): 321-32. PubMedID: 9864177.
    1. Three molecular determinants of malignant conversion and their potential as therapeutic targets.
      Dome JS, Look AT.
      Curr Opin Oncol, 1999; 11(1): 58-67. PubMedID: 9914880.
    1. Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas.
      Meyerhardt JA, Caca K, Eckstrand BC, Hu G, Lengauer C, Banavali S, Look AT, Fearon ER.
      Cell Growth Differ., 1999; 10(1): 35-42. PubMedID: 9950216.
    1. Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice.
      Hitzler JK, Soares HD, Drolet DW, Inaba T, O'Connel S, MG Rosenfeld , Morgan JI, Look AT.
      Brain Res., 1999; 820(1): 1-11. PubMedID: 10023025.
    1. Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes.
      Kuribara R, Kinoshita T, Miyajima A, Shinjyo T, Yoshihara T, Inukai T, Ozawa K, Look AT, Inaba T.
      Mol. Cell. Biol., 1999; 19(4): 2754-62. PubMedID: 10082541.
    1. Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1).
      Bodner SM, Naeve CW, Rakestraw KM, Jones BG, Valentine VA, Valentine MB, Luthardt FW, Willman CL, Raimondi SC, Downing JR, Roussel MF, Sherr CJ, Look AT.
      Gene, 1999; 229(1): 223-8. PubMedID: 10095122.
    1. cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia.
      Hitzler JK, Witte DP, Jenkins NA, Copeland NG, Gilbert DJ, Naeve CW, Look AT, Morris SW.
      Am. J. Pathol., 1999; 155(1): 53-9. PubMedID: 10393836.
    1. Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma.
      Reardon DA, Entrekin RE, Sublett J, Ragsdale S, Li H, Boyett J, Kepner JL, Look AT.
      Genes Chromosomes Cancer, 1999; 24(3): 230-7. PubMedID: 10451703.
    1. SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.
      Inukai T, Inoue A, Kurosawa H, Goi K, Shinjyo T, Ozawa K, Mao M, Inaba T, Look AT.
      Mol. Cell, 1999; 4(3): 343-52. PubMedID: 10518215.
    1. Hormone and fertility drug use and the risk of neuroblastoma: a report from the Children's Cancer Group and the Pediatric Oncology Group.
      Olshan AF, Smith J, Cook MN, Grufferman S, Pollock BH, Stram DO, Seeger RC, Look AT, Cohn SL, Castleberry RP, Bondy ML.
      Am. J. Epidemiol., 1999; 150(9): 930-8. PubMedID: 10547138.
    1. Significance of commonly used prognostic factors differs for children with T cell acute lymphocytic leukemia (ALL), as compared to those with B-precursor ALL. A Pediatric Oncology Group (POG) study.
      Pullen J, Shuster JJ, Link M, Borowitz M, Amylon M, Carroll AJ, Land V, Look AT, McIntyre B, Camitta B.
      Leukemia, 1999; 13(11): 1696-707. PubMedID: 10557041.
    1. Hemizygous deletions of chromosome band 16q24 in Wilms tumor: detection by fluorescence in situ hybridization.
      Shearer PD, Valentine MB, Grundy P, DeCou JM, Banavali SD, Komuro H, Green DM, Beckwith JB, Look AT.
      Cancer Genet. Cytogenet., 1999; 115(2): 100-5. PubMedID: 10598141.
    1. Lack of homozygously inactivated p73 in single-copy MYCN primary neuroblastomas and neuroblastoma cell lines.
      Kong XT, Valentine VA, Rowe ST, Valentine MB, Ragsdale ST, Jones BG, Wilkinson DA, Brodeur GM, Cohn SL, Look AT.
      Neoplasia, 1999; 1(1): 80-9. PubMedID: 10935473.
    1. p27KIP1 deletions in childhood acute lymphoblastic leukemia.
      Komuro H, Valentine MB, Rubnitz JE, Saito M, Raimondi SC, Carroll AJ, Yi T, Sherr CJ, Look AT.
      Neoplasia, 1999; 1(3): 253-61. PubMedID: 10935480.
    1. Identification of newly diagnosed children with acute lymphocytic leukemia at high risk for relapse.
      Shuster JJ, Camitta BM, Pullen J, Borowitz MJ, Carroll AJ, Look AT, Mahoney DH, Mahmoud H, Lauer SJ, Land VJ.
      Cancer Research Therapy and Control, 1999; 9: 101-7.
  15. 1998
    1. Arsenic and apoptosis in the treatment of acute promyelocytic leukemia.
      Look AT.
      J. Natl. Cancer Inst., 1998; 90(2): 86-8. PubMedID: 9450562.
    1. Molecular genetics of childhood leukemias.
      Rubnitz JE, Look AT.
      J. Pediatr. Hematol. Oncol., 1998; 20(1): 1-11. PubMedID: 9482406.
    1. Translocations involving chromosome 12p11-13, methotrexate metabolism, and outcome in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
      Whitehead VM, Vuchich MJ, Cooley L, Lauer SJ, Mahoney DH, Shuster JJ, Payment C, Bernstein ML, Akabutu JJ, Bowen T, Kamen BA, Watson MS, Look AT, Pullen DJ, Camitta B.
      Clin. Cancer Res., 1998; 4(1): 183-8. PubMedID: 9516969.
    1. Prognostic significance of age, MYCN oncogene amplification, tumor cell ploidy, and histology in 110 infants with stage D(S) neuroblastoma: the pediatric oncology group experience--a pediatric oncology group study.
      Katzenstein HM, Bowman LC, Brodeur GM, Thorner PS, Joshi VV, Smith EI, Look AT, Rowe ST, Nash MB, Holbrook T, Alvarado C, Rao PV, Castleberry RP, Cohn SL.
      J. Clin. Oncol., 1998; 16(6): 2007-17. PubMedID: 9626197.
    1. Chromosomal localization of the human smoothened gene (SMOH) to 7q32. 3 by fluorescence in situ hybridization and radiation hybrid mapping.
      Sublett JE, Entrekin RE, Look AT, Reardon DA.
      Genomics, 1998; 50(1): 112-4. PubMedID: 9628830.
    1. Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes.
      Ohi R, Feoktistova A, McCann S, Valentine V, Look AT, Lipsick JS, Gould KL.
      Mol. Cell. Biol., 1998; 18(7): 4097-108. PubMedID: 9632794.
    1. The chimeric E2A-HLF transcription factor abrogates p53-induced apoptosis in myeloid leukemia cells.
      Altura RA, Inukai T, Ashmun RA, Zambetti GP, Roussel MF, Look AT.
      Blood, 1998; 92(4): 1397-405. PubMedID: 9694729.
    1. Prognostic significance of sex in childhood B-precursor acute lymphoblastic leukemia: a Pediatric Oncology Group Study.
      Shuster JJ, Wacker P, Pullen J, Humbert J, Land VJ, Mahoney DH, Lauer S, Look AT, Borowitz MJ, Carroll AJ, Camitta B.
      J. Clin. Oncol., 1998; 16(8): 2854-63. PubMedID: 9704739.
    1. The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF.
      Inukai T, Inaba T, Ikushima S, Look AT.
      Mol. Cell. Biol., 1998; 18(10): 6035-43. PubMedID: 9742120.
    1. Molecular basis of leukemogenesis.
      Rubnitz JE, Look AT.
      Curr. Opin. Hematol., 1998; 5(4): 264-70. PubMedID: 9747633.
    1. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome.
      Nichols KE, Harkin DP, Levitz S, Krainer M, Kolquist KA, Genovese C, Bernard A, Ferguson M, Zuo L, Snyder E, Buckler AJ, Wise C, Ashley J, Lovett M, Valentine MB, Look AT, Gerald W, Housman DE, Haber DA.
      Proc. Natl. Acad. Sci. U.S.A., 1998; 95(23): 13765-70. PubMedID: 9811875.
    1. Fluorescence in situ hybridization analysis of chromosome 1p36 deletions in human MYCN amplified neuroblastoma.
      Komuro H, Valentine MB, Rowe ST, Kidd VJ, Makino S, Brodeur GM, Cohn SL, Look AT.
      J. Pediatr. Surg., 1998; 33(11): 1695-8. PubMedID: 9856898.
    1. Accumulation of methotrexate polyglutamates, ploidy and trisomies of both chromosomes 4 and 10 in lymphoblasts from children with B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group Study.
      Whitehead VM, Vuchich MJ, Cooley LD, Lauer SJ, Mahoney DH, Shuster JJ, Payment C, Koch PA, Akabutu JJ, Bowen T, Kamen BA, Ravindranath Y, Emami A, Look AT, Beardsley GP, Pullen DJ, Camitta B.
      Leuk. Lymphoma, 1998; 31(5): 507-19. PubMedID: 9922041.
  16. 1997
    1. Cell transformation mediated by homodimeric E2A-HLF transcription factors.
      Inukai T, Inaba T, Yoshihara T, Look AT.
      Mol. Cell. Biol., 1997; 17(3): 1417-24. PubMedID: 9032268.
    1. Genetic staging of unresectable or metastatic neuroblastoma in infants: a Pediatric Oncology Group study.
      Bowman LC, Castleberry RP, Cantor A, Joshi V, Cohn SL, Smith EI, Yu A, Brodeur GM, Hayes FA, Look AT.
      J. Natl. Cancer Inst., 1997; 89(5): 373-80. PubMedID: 9060959.
    1. E2A-HLF chimeric transcription factors in pro-B cell acute lymphoblastic leukemia.
      Look AT.
      Curr. Top. Microbiol. Immunol., 1997; 220: 45-53. PubMedID: 9103674.
    1. Identification and characterization of neogenin, a DCC-related gene.
      Meyerhardt JA, Look AT, Bigner SH, Fearon ER.
      Oncogene, 1997; 14(10): 1129-36. PubMedID: 9121761.
    1. Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes.
      Ikushima S, Inukai T, Inaba T, Nimer SD, Cleveland JL, Look AT.
      Proc. Natl. Acad. Sci. U.S.A., 1997; 94(6): 2609-14. PubMedID: 9122243.
    1. Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family.
      Gong X, Kaushal S, Ceccarelli E, Bogdanova N, Neville C, Nguyen T, Clark H, Khatib ZA, Valentine M, Look AT, Rosenthal N.
      Dev. Biol., 1997; 183(2): 166-82. PubMedID: 9126292.
    1. Prognostic significance of fluorescence intensity of surface marker expression in childhood B-precursor acute lymphoblastic leukemia. A Pediatric Oncology Group Study.
      Borowitz MJ, Shuster J, Carroll AJ, Nash M, Look AT, Camitta B, Mahoney D, Lauer SJ, Pullen DJ.
      Blood, 1997; 89(11): 3960-6. PubMedID: 9166833.
    1. Novel regions of chromosomal loss in familial neuroblastoma by comparative genomic hybridization.
      Altura RA, Maris JM, Li H, Boyett JM, Brodeur GM, Look AT.
      Genes Chromosomes Cancer, 1997; 19(3): 176-84. PubMedID: 9218999.
    1. Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization.
      Reardon DA, Michalkiewicz E, Boyett JM, Sublett JE, Entrekin RE, Ragsdale ST, Valentine MB, Behm FG, Li H, Heideman RL, Kun LE, Shapiro DN, Look AT.
      Cancer Res., 1997; 57(18): 4042-7. PubMedID: 9307291.
    1. Oncogenic transcription factors in the human acute leukemias.
      Look AT.
      Science, 1997; 278(5340): 1059-64. PubMedID: 9353180.
    1. Retrovirus-mediated gene transfer of NPM-ALK causes lymphoid malignancy in mice.
      Kuefer MU, Look AT, Pulford K, Behm FG, Pattengale PK, Mason DY, Morris SW.
      Blood, 1997; 90(8): 2901-10. PubMedID: 9376569.
    1. Characterization of human homologs of the Drosophila seven in absentia (sina) gene.
      Hu G, Chung YL, Glover T, Valentine V, Look AT, Fearon ER.
      Genomics, 1997; 46(1): 103-11. PubMedID: 9403064.
  17. 1996
    1. The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.
      Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW.
      Oncogene, 1996; 12(2): 265-75. PubMedID: 8570204.
    1. cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2).
      Kuefer MU, Look AT, Williams DC, Valentine V, Naeve CW, Behm FG, Mullersman JE, Yoneda-Kato N, Montgomery K, Kucherlapati R, Morris SW.
      Genomics, 1996; 35(2): 392-6. PubMedID: 8661158.
    1. Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor.
      Inaba T, Inukai T, Yoshihara T, Seyschab H, Ashmun RA, Canman CE, Laken SJ, Kastan MB, Look AT.
      Nature, 1996; 382(6591): 541-4. PubMedID: 8700228.
    1. Identification of novel regions of deletion in familial Wilms' tumor by comparative genomic hybridization.
      Altura RA, Valentine M, Li H, Boyett JM, Shearer P, Grundy P, Shapiro DN, Look AT.
      Cancer Res., 1996; 56(16): 3837-41. PubMedID: 8706032.
    1. MLL fusion genes in the 11q23 acute leukemias.
      Downing JR, Look AT.
      Cancer Treat. Res., 1996; 84: 73-92. PubMedID: 8724626.
    1. DNA index of glial tumors in children. Correlation with tumor grade and prognosis.
      Mathew P, Look T, Luo X, Ashmun R, Nash M, Gajjar A, Walter A, Kun L, Heideman RL.
      Cancer, 1996; 78(4): 881-6. PubMedID: 8756385.
    1. Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors.
      Li H, Lahti JM, Valentine M, Saito M, Reed SI, Look AT, Kidd VJ.
      Genomics, 1996; 32(2): 253-9. PubMedID: 8833152.
    1. Comparison of fluorescence in situ hybridization, cytogenetic analysis, and DNA index analysis to detect chromosomes 4 and 10 aneuploidy in pediatric acute lymphoblastic leukemia: a Pediatric Oncology Group study.
      Martin PL, Look AT, Schnell S, Harris MB, Pullen J, Shuster JJ, Carroll AJ, Pettenati MJ, Rao PN.
      J. Pediatr. Hematol. Oncol., 1996; 18(2): 113-21. PubMedID: 8846121.
    1. Deletion of 1p36 in childhood endodermal sinus tumors by two-color fluorescence in situ hybridization: a pediatric oncology group study.
      Perlman EJ, Valentine MB, Griffin CA, Look AT.
      Genes Chromosomes Cancer, 1996; 16(1): 15-20. PubMedID: 9162192.
  18. 1995
    1. Significance of chromosome 1p loss of heterozygosity in neuroblastoma.
      Maris JM, White PS, Beltinger CP, Sulman EP, Castleberry RP, Shuster JJ, Look AT, Brodeur GM.
      Cancer Res., 1995; 55(20): 4664-9. PubMedID: 7553646.
    1. Stromal cell-mediated transcriptional regulation of the CD13/aminopeptidase N gene in leukemic cells.
      Saito M, Kumagai M, Okazaki T, Nakazawa S, Shapiro LH, Look AT, Campana D.
      Leukemia, 1995; 9(9): 1508-16. PubMedID: 7658720.
    1. Biological variables in thoracic neuroblastoma: a Pediatric Oncology Group study.
      Morris JA, Shcochat SJ, Smith EI, Look AT, Brodeur GM, Cantor AB, Castleberry RP.
      J. Pediatr. Surg., 1995; 30(2): 296-302; discussion 302-3. PubMedID: 7738754.
    1. E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF.
      Yoshihara T, Inaba T, Shapiro LH, Kato JY, Look AT.
      Mol. Cell. Biol., 1995; 15(6): 3247-55. PubMedID: 7760820.
    1. Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line.
      Saito M, Helin K, Valentine MB, Griffith BB, Willman CL, Harlow E, Look AT.
      Genomics, 1995; 25(1): 130-8. PubMedID: 7774910.
    1. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
      Morris SW, Kirstein MN, Valentine MB, Dittmer K, Shapiro DN, Look AT, Saltman DL.
      Science, 1995; 267(5196): 316-7. PubMedID: 7824924.
    1. Lack of correlation of N-myc gene amplification with prognosis in localized neuroblastoma: a Pediatric Oncology Group study.
      Cohn SL, Look AT, Joshi VV, Holbrook T, Salwen H, Chagnovich D, Chesler L, Rowe ST, Valentine MB, Komuro H.
      Cancer Res., 1995; 55(4): 721-6. PubMedID: 7850780.
    1. Oncogenic role of "master" transcription factors in human leukemias and sarcomas: a developmental model.
      Look AT.
      Adv. Cancer Res., 1995; 67: 25-57. PubMedID: 8571816.
    1. Fusion genes and their hybrid proteins in human leukemias and lymphomas.
      Look AT.
      Proc. Assoc. Am. Physicians, 1995; 107(2): 175-80. PubMedID: 8624850.
    1. Transcriptional regulation in myeloid cell differentiation.
      Shapiro LH, Look AT.
      Curr. Opin. Hematol., 1995; 2(1): 3-11. PubMedID: 9371966.
    1. Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia.
      Okuda T, Shurtleff SA, Valentine MB, Raimondi SC, Head DR, Behm F, Curcio-Brint AM, Liu Q, Pui CH, Sherr CJ, Beach D, Look AT, Downing JR.
      Blood, 1995; 85(9): 2321-30. PubMedID: 7727766.
    1. A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3.
      White PS, Maris JM, Beltinger C, Sulman E, Marshall HN, Fujimori M, Kaufman BA, Biegel JA, Allen C, Hilliard C, Valentine MB, Look AT, Enomoto H, Sakiyama S, Brodeur GM.
      Proc. Natl. Acad. Sci. U.S.A., 1995; 92(12): 5520-4. PubMedID: 7777541.
  19. 1994
    1. Chromosomal localization and cDNA cloning of the human DBP and TEF genes.
      Khatib ZA, Inaba T, Valentine M, Look AT.
      Genomics, 1994; 23(2): 344-51. PubMedID: 7835883.
    1. Molecular biology of leukemia and lymphoma.
      Look AT, Downing JR.
      Rev. Invest. Clin., 1994; : 124-34. PubMedID: 7886296.
    1. Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma.
      Lahti JM, Valentine M, Xiang J, Jones B, Amann J, Grenet J, Richmond G, Look AT, Kidd VJ.
      Nat. Genet., 1994; 7(3): 370-5. PubMedID: 7920654.
    1. Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1).
      Zhang DE, Fujioka K, Hetherington CJ, Shapiro LH, Chen HM, Look AT, Tenen DG.
      Mol. Cell. Biol., 1994; 14(12): 8085-95. PubMedID: 7969146.
    1. Screening for neuroblastoma (NB) in North America: the Quebec Project.
      Woods WG, Lemieux B, Leclerc JM, Bernstein ML, Brisson L, Brossard J, Brodeur GM, Look AT, Robison LL, Shuster JJ.
      Prog. Clin. Biol. Res., 1994; 385: 377-82. PubMedID: 7972234.
    1. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
      Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, Look AT.
      Science, 1994; 263(5151): 1281-4. PubMedID: 8122112.
    1. DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein.
      Inaba T, Shapiro LH, Funabiki T, Sinclair AE, Jones BG, Ashmun RA, Look AT.
      Mol. Cell. Biol., 1994; 14(5): 3403-13. PubMedID: 8164688.
    1. Cytogenetic abnormalities in two cases of neuroblastoma.
      Lo R, Perlman E, Hawkins AL, Hayashi R, Wechsler DS, Look AT, Griffin CA.
      Cancer Genet. Cytogenet., 1994; 74(1): 30-4. PubMedID: 8194044.
    1. Splice-site mutation of the p53 gene in a family with hereditary breast-ovarian cancer.
      Jolly KW, Malkin D, Douglass EC, Brown TF, Sinclair AE, Look AT.
      Oncogene, 1994; 9(1): 97-102. PubMedID: 8302608.
  20. 1993
    1. Detection of N-myc gene amplification by fluorescence in situ hybridization. Diagnostic utility for neuroblastoma.
      Shapiro DN, Valentine MB, Rowe ST, Sinclair AE, Sublett JE, Roberts WM, Look AT.
      Am. J. Pathol., 1993; 142(5): 1339-46. PubMedID: 7684192.
    1. Clinical significance of CD34 expression in childhood acute lymphoblastic leukemia.
      Pui CH, Hancock ML, Head DR, Rivera GK, Look AT, Sandlund JT, Behm FG.
      Blood, 1993; 82(3): 889-94. PubMedID: 7687897.
    1. A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL gene.
      Jani Sait SN, Raimondi SC, Look AT, Gill H, Thirman M, Diaz MO, Shows TB.
      Genes Chromosomes Cancer, 1993; 7(1): 28-31. PubMedID: 7688552.
    1. Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key!
      Shipp MA, Look AT.
      Blood, 1993; 82(4): 1052-70. PubMedID: 8102558.
    1. Coronavirus receptor specificity.
      Holmes KV, Dveksler G, Gagneten S, Yeager C, Lin SH, Beauchemin N, Look AT, Ashmun R, Dieffenbach C.
      Adv. Exp. Med. Biol., 1993; 342: 261-6. PubMedID: 8209740.
    1. Use of clinical and laboratory features to define prognostic subgroups in B-precursor acute lymphoblastic leukemia: experience of the Pediatric Oncology Group.
      Borowitz MJ, Carroll AJ, Shuster JJ, Look AT, Behm FG, Pullen DJ, Land VJ, Steuber P, Crist WM.
      Recent Results Cancer Res., 1993; 131: 257-67. PubMedID: 8210645.
    1. Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.
      Khatib ZA, Matsushime H, Valentine M, Shapiro DN, Sherr CJ, Look AT.
      Cancer Res., 1993; 53(22): 5535-41. PubMedID: 8221695.
    1. Relation of tumor-cell ploidy to survival in children with medulloblastoma.
      Gajjar AJ, Heideman RL, Douglass EC, Kun LE, Kovnar EH, Sanford RA, Fairclough DL, Ayers D, Look AT.
      J. Clin. Oncol., 1993; 11(11): 2211-7. PubMedID: 8229136.
    1. The retinoblastoma protein binds to a family of E2F transcription factors.
      Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K.
      Mol. Cell. Biol., 1993; 13(12): 7813-25. PubMedID: 8246996.
    1. Transitional pre-B-cell acute lymphoblastic leukemia of childhood is associated with favorable prognostic clinical features and an excellent outcome: a Pediatric Oncology Group study.
      Koehler M, Behm FG, Shuster J, Crist W, Borowitz M, Look AT, Head D, Carroll AJ, Land V, Steuber P.
      Leukemia, 1993; 7(12): 2064-8. PubMedID: 8255107.
    1. Management of cytogenetic data in multi-center leukemia trials.
      Shuster JJ, Carroll AJ, Look TA, Pui CH, Land VJ, Jackson J, Pullen DJ, Steuber CP, Crist WM.
      Comput Methods Programs Biomed, 1993; 40(4): 269-77. PubMedID: 8261774.
    1. Cell transformation by ras and regulation of its protein product.
      Lowy DR, Johnson MR, DeClue JE, Cen H, Zhang K, Papageorge AG, Vass WC, Willumsen BM, Valentine MB, Look AT.
      Ciba Found. Symp., 1993; 176: 67-80; discussion 80-4. PubMedID: 8299427.
    1. Correlation between morphologic and other prognostic markers of neuroblastoma. A study of histologic grade, DNA index, N-myc gene copy number, and lactic dehydrogenase in patients in the Pediatric Oncology Group.
      Joshi VV, Cantor AB, Brodeur GM, Look AT, Shuster JJ, Altshuler G, Larkin EW, Holbrook CT, Silverman JF, Norris HT.
      Cancer, 1993; 71(10): 3173-81. PubMedID: 8490848.
    1. Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras.
      Johnson MR, Look AT, DeClue JE, Valentine MB, Lowy DR.
      Proc. Natl. Acad. Sci. U.S.A., 1993; 90(12): 5539-43. PubMedID: 8516298.
    1. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment.
      Brodeur GM, Pritchard J, Berthold F, Carlsen NL, Castel V, Castelberry RP, De Bernardi B, Evans AE, Favrot M, Hedborg F, Kaneko M, Kemshead J, Lampert F, Lee REJ, Look AT, Pearson ADJ, Philip T, Roald B, Sawada T, Seeger RC, Tsuchida Y, Voute PA.
      J. Clin. Oncol., 1993; 11(8): 1466-77. PubMedID: 8336186.
  21. 1992
    1. Sublocalization of the chromosome 5 breakpoint of the 3;5 translocation in myelodysplastic syndromes and acute myeloid leukemia.
      Morris SW, Foust JT, Valentine MB, Roberts WM, Shapiro DN, Look AT.
      Genes Chromosomes Cancer, 1992; 5(4): 385-91. PubMedID: 1283327.
    1. Human aminopeptidase N is a receptor for human coronavirus 229E.
      Yeager CL, Ashmun RA, Williams RK, Cardellichio CB, Shapiro LH, Look AT, Holmes KV.
      Nature, 1992; 357(6377): 420-2. PubMedID: 1350662.
    1. Deletion of the zinc-binding motif of CD13/aminopeptidase N molecules results in loss of epitopes that mediate binding of inhibitory antibodies.
      Ashmun RA, Shapiro LH, Look AT.
      Blood, 1992; 79(12): 3344-9. PubMedID: 1375850.
    1. Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (greater than 50 chromosomes) B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group study.
      Whitehead VM, Vuchich MJ, Lauer SJ, Mahoney D, Carroll AJ, Shuster JJ, Esseltine DW, Payment C, Look AT, Akabutu J.
      Blood, 1992; 80(5): 1316-23. PubMedID: 1381244.
    1. Chromosomal sublocalization of the 2;13 translocation breakpoint in alveolar rhabdomyosarcoma.
      Shapiro DN, Valentine MB, Sublett JE, Sinclair AE, Tereba AM, Scheffer H, Buys CH, Look AT.
      Genes Chromosomes Cancer, 1992; 4(3): 241-9. PubMedID: 1382566.
    1. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia.
      Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT.
      Science, 1992; 257(5069): 531-4. PubMedID: 1386162.
    1. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes.
      Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT.
      Genomics, 1992; 13(3): 565-74. PubMedID: 1386335.
    1. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt.
      Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H.
      Blood, 1992; 80(7): 1825-31. PubMedID: 1391946.
    1. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35.
      Morris SW, Nelson N, Valentine MB, Shapiro DN, Look AT, Kozlosky CJ, Beckmann MP, Cerretti DP.
      Genomics, 1992; 14(3): 685-91. PubMedID: 1427896.
    1. Screening for neuroblastoma in North America. 2-year results from the Quebec Project.
      Woods WG, Tuchman M, Bernstein ML, Leclerc JM, Brisson L, Look T, Brodeur GM, Shimada H, Hann HL, Robison LL.
      Am J Pediatr Hematol Oncol, 1992; 14(4): 312-9. PubMedID: 1456396.
    1. Transcription of the human colony-stimulating factor-1 receptor gene is regulated by separate tissue-specific promoters.
      Roberts WM, Shapiro LH, Ashmun RA, Look AT.
      Blood, 1992; 79(3): 586-93. PubMedID: 1531036.
    1. Lack of CD45 antigen on blast cells in childhood acute lymphoblastic leukemia is associated with chromosomal hyperdiploidy and other favorable prognostic features.
      Behm FG, Raimondi SC, Schell MJ, Look AT, Rivera GK, Pui CH.
      Blood, 1992; 79(4): 1011-6. PubMedID: 1531305.
    1. Ploidy of lymphoblasts is the strongest predictor of treatment outcome in B-progenitor cell acute lymphoblastic leukemia of childhood: a Pediatric Oncology Group study.
      Trueworthy R, Shuster J, Look T, Crist W, Borowitz M, Carroll A, Frankel L, Harris M, Wagner H, Haggard M.
      J. Clin. Oncol., 1992; 10(4): 606-13. PubMedID: 1548523.
    1. Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas.
      Fong CT, White PS, Peterson K, Sapienza C, Cavenee WK, Kern SE, Vogelstein B, Cantor AB, Look AT, Brodeur GM.
      Cancer Res., 1992; 52(7): 1780-5. PubMedID: 1551108.
    1. Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.
      Malkin D, Jolly KW, Barbier N, Look AT, Friend SH, Gebhardt MC, Andersen TI, Børresen AL, Li FP, Garber J.
      N. Engl. J. Med., 1992; 326(20): 1309-15. PubMedID: 1565144.
    1. Monoclonal antibodies defining shared human macrophage-endothelial antigens.
      Koch AE, Burrows JC, Domer PH, Ashmun RA, Look AT, Leibovich SJ.
      Pathobiology, 1992; 60(2): 59-67. PubMedID: 1571092.
    1. Current results of studies of immunophenotype-, age- and leukocyte-based therapy for children with acute lymphoblastic leukemia. The Pediatric Oncology Group.
      Crist W, Shuster J, Look T, Borowitz M, Behm F, Bowman P, Frankel L, Pullen J, Krance R, Steuber P.
      Leukemia, 1992; 6: 162-6. PubMedID: 1578922.
    1. Trisomy of leukemic cell chromosomes 4 and 10 identifies children with B-progenitor cell acute lymphoblastic leukemia with a very low risk of treatment failure: a Pediatric Oncology Group study.
      Harris MB, Shuster JJ, Carroll A, Look AT, Borowitz MJ, Crist WM, Nitschke R, Pullen J, Steuber CP, Land VJ.
      Blood, 1992; 79(12): 3316-24. PubMedID: 1596572.
    1. Different molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia.
      Privitera E, Kamps MP, Hayashi Y, Inaba T, Shapiro LH, Raimondi SC, Behm F, Hendershot L, Carroll AJ, Baltimore D, Look AT.
      Blood, 1992; 79(7): 1781-8. PubMedID: 1348433.
    1. Neuroblastoma. Effect of genetic factors on prognosis and treatment.
      Brodeur GM, Azar C, Brother M, Hiemstra J, Kaufman B, Marshall H, Moley J, Nakagawara A, Saylors R, Scavarda N, Schneider S, Wasson J, White P, Seeger R, Look AT, Castleberry R.
      Cancer, 1992; 70(6): 1685-94. PubMedID: 1325279.
  22. 1991
    1. Improved outcome in childhood acute lymphoblastic leukaemia with reinforced early treatment and rotational combination chemotherapy.
      Rivera GK, Raimondi SC, Hancock ML, Behm FG, Pui CH, Abromowitch M, Mirro J, Ochs JS, Look AT, Williams DL.
      Lancet, 1991; 337(8733): 61-6. PubMedID: 1670723.
    1. The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials.
      Kamps MP, Look AT, Baltimore D.
      Genes Dev., 1991; 5(3): 358-68. PubMedID: 1672117.
    1. Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells.
      Shapiro LH, Ashmun RA, Roberts WM, Look AT.
      J. Biol. Chem., 1991; 266(18): 11999-2007. PubMedID: 1675638.
    1. Reassignment of the human CSF1 gene to chromosome 1p13-p21.
      Morris SW, Valentine MB, Shapiro DN, Sublett JE, Deaven LL, Foust JT, Roberts WM, Cerretti DP, Look AT.
      Blood, 1991; 78(8): 2013-20. PubMedID: 1912583.
    1. Relationship of tumor-cell ploidy to histologic subtype and treatment outcome in children and adolescents with unresectable rhabdomyosarcoma.
      Shapiro DN, Parham DM, Douglass EC, Ashmun R, Webber BL, Newton WA, Hancock ML, Maurer HM, Look AT.
      J. Clin. Oncol., 1991; 9(1): 159-66. PubMedID: 1985166.
    1. New recurring chromosomal translocations in childhood acute lymphoblastic leukemia.
      Raimondi SC, Privitera E, Williams DL, Look AT, Behm F, Rivera GK, Crist WM, Pui CH.
      Blood, 1991; 77(9): 2016-22. PubMedID: 2018838.
    1. Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study.
      Look AT, Hayes FA, Shuster JJ, Douglass EC, Castleberry RP, Bowman LC, Smith EI, Brodeur GM.
      J. Clin. Oncol., 1991; 9(4): 581-91. PubMedID: 2066755.
    1. Risk of adverse events in children completing treatment for acute lymphoblastic leukemia: St. Jude Total Therapy studies VIII, IX, and X.
      Pui CH, Dodge RK, Look AT, George SL, Rivera GK, Abromowitch M, Ochs J, Evans WE, Crist WM, Simone JV.
      J. Clin. Oncol., 1991; 9(8): 1341-7. PubMedID: 2072137.
  23. 1990
    1. Prognostic significance of CD34 expression in childhood B-precursor acute lymphocytic leukemia: a Pediatric Oncology Group study.
      Borowitz MJ, Shuster JJ, Civin CI, Carroll AJ, Look AT, Behm FG, Land VJ, Pullen DJ, Crist WM.
      J. Clin. Oncol., 1990; 8(8): 1389-98. PubMedID: 1696310.
    1. Metalloprotease activity of CD13/aminopeptidase N on the surface of human myeloid cells.
      Ashmun RA, Look AT.
      Blood, 1990; 75(2): 462-9. PubMedID: 1967220.
    1. Aminopeptidase N is directly sorted to the apical domain in MDCK cells.
      Wessels HP, Hansen GH, Fuhrer C, Look AT, Sjöström H, Norén O, Spiess M.
      J. Cell Biol., 1990; 111(6): 2923-30. PubMedID: 1980123.
    1. Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia.
      Pui CH, Crist WM, Look AT.
      Blood, 1990; 76(8): 1449-63. PubMedID: 2207320.
    1. Abnormalities of the long arm of chromosome 6 in childhood acute lymphoblastic leukemia.
      Hayashi Y, Raimondi SC, Look AT, Behm FG, Kitchingman GR, Pui CH, Rivera GK, Williams DL.
      Blood, 1990; 76(8): 1626-30. PubMedID: 2207332.
    1. Allogeneic bone marrow transplantation in a program of intensive sequential chemotherapy for children and young adults with acute nonlymphocytic leukemia in first remission.
      Dahl GV, Kalwinsky DK, Mirro J, Look AT, Pui CH, Murphy SB, Mason C, Ruggiero M, Schell M, Johnson FL.
      J. Clin. Oncol., 1990; 8(2): 295-303. PubMedID: 2299372.
    1. Presenting features and treatment outcome of adolescents with acute lymphoblastic leukemia.
      Santana VM, Dodge RK, Crist WM, Rivera GK, Look AT, Behm FG, Raimondi SC, Pui CH.
      Leukemia, 1990; 4(2): 87-90. PubMedID: 2304360.
    1. Development and characterization of pediatric osteosarcoma xenografts.
      Meyer WH, Houghton JA, Houghton PJ, Webber BL, Douglass EC, Look AT.
      Cancer Res., 1990; 50(9): 2781-5. PubMedID: 2328504.
    1. Oncogene amplification in pediatric brain tumors.
      Wasson JC, Saylors RL, Zeltzer P, Friedman HS, Bigner SH, Burger PC, Bigner DD, Look AT, Douglass EC, Brodeur GM.
      Cancer Res., 1990; 50(10): 2987-90. PubMedID: 2334901.
    1. Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study.
      Crist WM, Carroll AJ, Shuster JJ, Behm FG, Whitehead M, Vietti TJ, Look AT, Mahoney D, Ragab A, Pullen DJ.
      Blood, 1990; 76(1): 117-22. PubMedID: 2364165.
    1. Cytogenetics of pre-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19).
      Raimondi SC, Behm FG, Roberson PK, Williams DL, Pui CH, Crist WM, Look AT, Rivera GK.
      J. Clin. Oncol., 1990; 8(8): 1380-8. PubMedID: 2380759.
    1. Near-triploid and near-tetraploid acute lymphoblastic leukemia of childhood.
      Pui CH, Carroll AJ, Head D, Raimondi SC, Shuster JJ, Crist WM, Link MP, Borowitz MJ, Behm FG, Land VJ, Nash MB, Pullen DJ, Look AT.
      Blood, 1990; 76(3): 590-6. PubMedID: 2378987.
    1. Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line.
      Pui CH, Carroll AJ, Raimondi SC, Land VJ, Crist WM, Shuster JJ, Williams DL, Pullen DJ, Borowitz MJ, Behm FG, Look AT.
      Blood, 1990; 75(5): 1170-7. PubMedID: 2306521.
  24. 1989
    1. Monoclonal antibodies to the human CSF-1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells.
      Ashmun RA, Look AT, Roberts WM, Roussel MF, Seremetis S, Ohtsuka M, Sherr CJ.
      Blood, 1989; 73(3): 827-37. PubMedID: 2465043.
    1. Constellations of genetic abnormalities predict clinical outcome in childhood malignancies.
      Look AT.
      Haematol Blood Transfus, 1989; 32: 113-20. PubMedID: 2560443.
    1. Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N.
      Look AT, Ashmun RA, Shapiro LH, Peiper SC.
      J. Clin. Invest., 1989; 83(4): 1299-307. PubMedID: 2564851.
    1. Closely linked loci on the long arm of chromosome 13 flank a specific 2;13 translocation breakpoint in childhood rhabdomyosarcoma.
      Valentine M, Douglass EC, Look AT.
      Cytogenet. Cell Genet., 1989; 52(3): 128-32. PubMedID: 2630183.
    1. Prognostic importance of structural chromosomal abnormalities in children with hyperdiploid (greater than 50 chromosomes) acute lymphoblastic leukemia.
      Pui CH, Raimondi SC, Dodge RK, Rivera GK, Fuchs LA, Abromowitch M, Look AT, Furman WL, Crist WM, Williams DL.
      Blood, 1989; 73(7): 1963-7. PubMedID: 2713510.
    1. Amplification of the gli gene in childhood sarcomas.
      Roberts WM, Douglass EC, Peiper SC, Houghton PJ, Look AT.
      Cancer Res., 1989; 49(19): 5407-13. PubMedID: 2766305.
  25. 1988
    1. Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes.
      Roberts WM, Look AT, Roussel MF, Sherr CJ.
      Cell, 1988; 55(4): 655-61. PubMedID: 2846185.
    1. The cytogenetics of childhood leukemia: clinical and biologic implications.
      Look AT.
      Pediatr. Clin. North Am., 1988; 35(4): 723-41. PubMedID: 3047651.
    1. High-dose methotrexate improves clinical outcome in children with acute lymphoblastic leukemia: St. Jude Total Therapy Study X.
      Abromowitch M, Ochs J, Pui CH, Kalwinsky D, Rivera GK, Fairclough D, Look AT, Hustu HO, Murphy SB, Evans WE.
      Med. Pediatr. Oncol., 1988; 16(5): 297-303. PubMedID: 3054451.
    1. Clinical importance of near-diploid tumor stem lines in patients with osteosarcoma of an extremity.
      Look AT, Douglass EC, Meyer WH.
      N. Engl. J. Med., 1988; 318(24): 1567-72. PubMedID: 3163773.
    1. Intensified chemotherapy for childhood lymphoblastic leukemia: modifications and results of induction treatment in St. Jude Study XI.
      Rivera GK, Kalwinsky DK, Mirro J, Pui CH, Abromowitch M, Ochs J, Furman W, Santana V, Look AT, Dow LW.
      An. Esp. Pediatr., 1988; 29: 83-8. PubMedID: 3214044.
    1. Molecular cloning, expression, and chromosomal localization of a human gene encoding the CD33 myeloid differentiation antigen.
      Peiper SC, Ashmun RA, Look AT.
      Blood, 1988; 72(1): 314-21. PubMedID: 3390608.
  26. 1987
    1. Combined etoposide and 5-azacitidine in children and adolescents with refractory or relapsed acute nonlymphocytic leukemia: a Pediatric Oncology Group Study.
      Hakami N, Look AT, Steuber PC, Krischer J, Castleberry R, Harris R, Ravindranath Y, Vietti TJ.
      J. Clin. Oncol., 1987; 5(7): 1022-5. PubMedID: 2439659.
    1. Oncogene activation in hematopoietic malignancies.
      Sherr CJ, Look AT.
      Monogr Pathol, 1987; (29): 225-48. PubMedID: 2884561.
    1. A comparison of cytokinetically based versus intensive chemotherapy for childhood acute myelogenous leukemia.
      Dahl GV, Kalwinsky DK, Mirro J, Look AT.
      Haematol Blood Transfus, 1987; 30: 83-7. PubMedID: 3305227.
    1. Hypodiploidy is associated with a poor prognosis in childhood acute lymphoblastic leukemia.
      Pui CH, Williams DL, Raimondi SC, Rivera GK, Look AT, Dodge RK, George SL, Behm FG, Crist WM, Murphy SB.
      Blood, 1987; 70(1): 247-53. PubMedID: 3474042.
    1. Teniposide plus cytarabine improves outcome in childhood acute lymphoblastic leukemia presenting with a leukocyte count greater than or equal to 100 x 10(9)/L.
      Dahl GV, Rivera GK, Look AT, Hustu HO, Kalwinsky DK, Abromowitch M, Mirro J, Ochs J, Murphy SB, Dodge RK.
      J. Clin. Oncol., 1987; 5(7): 1015-21. PubMedID: 3474355.
    1. Limiting toxicities during intensified remission induction chemotherapy for childhood acute lymphocytic leukemia.
      Rivera GK, Kovnar E, Pui CH, Dahl GV, Abromowitch M, Ochs JJ, Look AT, Kalwinsky DK, Mirro J, Dow LW.
      Haematol Blood Transfus, 1987; 30: 156-60. PubMedID: 3476354.
    1. Prognostic value of cellular DNA content in acute lymphoblastic leukemia of childhood.
      Look AT, Roberson PK, Murphy SB.
      N. Engl. J. Med., 1987; 317(26): 1666. PubMedID: 3479686.
    1. Expression of the human monocyte membrane antigen gp55 by murine fibroblasts after DNA-mediated gene transfer.
      Ashmun RA, Peiper SC, Rebentisch MB, Look AT.
      Blood, 1987; 69(3): 886-92. PubMedID: 3545322.
  27. 1986
    1. Molecular cloning, expression, and chromosomal localization of the gene encoding a human myeloid membrane antigen (gp150).
      Look AT, Peiper SC, Rebentisch MB, Ashmun RA, Roussel MF, Lemons RS, Le Beau MM, Rubin CM, Sherr CJ.
      J. Clin. Invest., 1986; 78(4): 914-21. PubMedID: 2428842.
    1. Induction failures in childhood acute nonlymphocytic leukemia: etoposide/5-azacytidine for cases refractory to daunorubicin/cytarabine.
      Kalwinsky DK, Dahl GV, Mirro J, Jackson CW, Look AT.
      Med. Pediatr. Oncol., 1986; 14(5): 245-50. PubMedID: 2431255.
    1. Cytogenetic features and serum lactic dehydrogenase level predict a poor treatment outcome for children with pre-B-cell leukemia.
      Pui CH, Williams DL, Kalwinsky DK, Look AT, Melvin SL, Dodge RK, Rivera G, Murphy SB, Dahl GV.
      Blood, 1986; 67(6): 1688-92. PubMedID: 2939898.
    1. Unfavorable presenting clinical and laboratory features are associated with CALLA-negative non-T, non-B lymphoblastic leukemia in children.
      Pui CH, Williams DL, Raimondi SC, Melvin SL, Behm FG, Look AT, Dahl GV, Rivera GK, Kalwinsky DK, Mirro J.
      Leuk. Res., 1986; 10(11): 1287-92. PubMedID: 2948078.
    1. Hyperdiploidy and chromosomal rearrangements define the anaplastic variant of Wilms' tumor.
      Douglass EC, Look AT, Webber B, Parham D, Wilimas JA, Green AA, Roberson PK.
      J. Clin. Oncol., 1986; 4(6): 975-81. PubMedID: 3012007.
    1. The v-fms oncogene induces factor independence and tumorigenicity in CSF-1 dependent macrophage cell line.
      Wheeler EF, Rettenmier CW, Look AT, Sherr CJ.
      Nature, 1986; 324(6095): 377-80. PubMedID: 3024013.
    1. Reversal of Vinca alkaloid resistance but not multiple drug resistance in human leukemic cells by verapamil.
      Beck WT, Cirtain MC, Look AT, Ashmun RA.
      Cancer Res., 1986; 46(2): 778-84. PubMedID: 3455678.
    1. Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect.
      Evans WE, Crom WR, Abromowitch M, Dodge R, Look AT, Bowman WP, George SL, Pui CH.
      N. Engl. J. Med., 1986; 314(8): 471-7. PubMedID: 3456079.
    1. Chromosomal translocations play a unique role in influencing prognosis in childhood acute lymphoblastic leukemia.
      Williams DL, Harber J, Murphy SB, Look AT, Kalwinsky DK, Rivera G, Melvin SL, Stass S, Dahl GV.
      Blood, 1986; 68(1): 205-12. PubMedID: 3459555.
    1. Early results of intensified remission induction chemotherapy for childhood acute lymphocytic leukemia.
      Rivera GK, George SL, Williams D, Look AT, Abromowitch M, Pui CH, Ochs JJ, Dahl GV, Kalwinsky DK, Mirro J.
      Med. Pediatr. Oncol., 1986; 14(3): 177-81. PubMedID: 3462464.
    1. Amplification of genes encoding human myeloid membrane antigens after DNA-mediated gene transfer.
      Look AT, Peiper SC, Douglass EC, Trent JM, Sherr CJ.
      Blood, 1986; 67(3): 637-45. PubMedID: 3511983.
    1. The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences.
      Wheeler EF, Roussel MF, Hampe A, Walker MH, Fried VA, Look AT, Rettenmier CW, Sherr CJ.
      J. Virol., 1986; 59(2): 224-33. PubMedID: 3525854.
    1. Inverse relationship between megakaryocyte buoyant density and maturity.
      Jackson CW, Steward SA, Brown LK, Look AT.
      Br. J. Haematol., 1986; 64(1): 33-43. PubMedID: 3756103.
  28. 1985
    1. The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1.
      Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley ER.
      Cell, 1985; 41(3): 665-76. PubMedID: 2408759.
    1. Abnormalities of chromosomes 1 and 11 in Wilms' tumor.
      Douglass EC, Wilimas JA, Green AA, Look AT.
      Cancer Genet. Cytogenet., 1985; 14(3): 331-8. PubMedID: 2981607.
    1. Prognostic importance of blast cell DNA content in childhood acute lymphoblastic leukemia.
      Look AT, Roberson PK, Williams DL, Rivera G, Bowman WP, Pui CH, Ochs J, Abromowitch M, Kalwinsky D, Dahl GV.
      Blood, 1985; 65(5): 1079-86. PubMedID: 3158360.
    1. Central nervous system leukemia in children with acute nonlymphoblastic leukemia.
      Pui CH, Dahl GV, Kalwinsky DK, Look AT, Mirro J, Dodge RK, Simone JV.
      Blood, 1985; 66(5): 1062-7. PubMedID: 3840394.
    1. A novel treatment of childhood lymphoblastic non-Hodgkin's lymphoma: early and intermittent use of teniposide plus cytarabine.
      Dahl GV, Rivera G, Pui CH, Mirro J, Ochs J, Kalwinsky DK, Abromowitch M, Look AT, Murphy SB.
      Blood, 1985; 66(5): 1110-4. PubMedID: 3840395.
    1. Recent results from Total Therapy Study X for standard and high risk acute lymphoblastic leukemia in children: recognition of new clinical and biologic risk features.
      Murphy SB, Dahl GV, Look AT, Ochs J, Abromowitch M, Pui CH, Bowman WP, Simone JV, Kalwinsky DK, Evans WE.
      Haematol Blood Transfus, 1985; 29: 78-81. PubMedID: 3861494.
    1. Serum lactic dehydrogenase level has prognostic value in childhood acute lymphoblastic leukemia.
      Pui CH, Dodge RK, Dahl GV, Rivera G, Look AT, Kalwinsky D, Bowman WP, Ochs J, Abromowitch M, Mirro J.
      Blood, 1985; 66(4): 778-82. PubMedID: 3862434.
    1. The emerging genetics of acute lymphoblastic leukemia: clinical and biologic implications.
      Look AT.
      Semin. Oncol., 1985; 12(2): 92-104. PubMedID: 3892696.
    1. Unexpectedly severe toxicity from intensive early treatment of childhood lymphoblastic leukemia.
      Rivera GK, Evans WE, Kalwinsky DK, Mirro J, Ochs J, Dow LW, Abromowitch M, Pui CH, Dahl GV, Look AT.
      J. Clin. Oncol., 1985; 3(2): 201-6. PubMedID: 3918144.
    1. Transfer and expression of the gene encoding a human myeloid membrane antigen (gp150).
      Look AT, Peiper SC, Rebentisch MB, Ashmun RA, Roussel MF, Rettenmier CW, Sherr CJ.
      J. Clin. Invest., 1985; 75(2): 569-79. PubMedID: 3973018.
    1. Transmembrane orientation of glycoproteins encoded by the v-fms oncogene.
      Rettenmier CW, Roussel MF, Quinn CO, Kitchingman GR, Look AT, Sherr CJ.
      Cell, 1985; 40(4): 971-81. PubMedID: 3986905.
    1. Cyclophosphamide/etoposide: effective reinduction therapy for children with acute nonlymphocytic leukemia in relapse.
      Kalwinsky DK, Dahl GV, Mirro J, Look AT.
      Cancer Treat Rep, 1985; 69(7): 887-9. PubMedID: 4016796.
  29. 1984
    1. Quantitative variation of the common acute lymphoblastic leukemia antigen (gp100) on leukemic marrow blasts.
      Look AT, Melvin SL, Brown LK, Dockter ME, Roberson PK, Murphy SB.
      J. Clin. Invest., 1984; 73(6): 1617-28. PubMedID: 6233301.
    1. Bone-marrow transplantation in a patient with sickle-cell anemia.
      Johnson FL, Look AT, Gockerman J, Ruggiero MR, Dalla-Pozza L, Billings FT.
      N. Engl. J. Med., 1984; 311(12): 780-3. PubMedID: 6382010.
    1. Cell surface expression of v-fms-coded glycoproteins is required for transformation.
      Roussel MF, Rettenmier CW, Look AT, Sherr CJ.
      Mol. Cell. Biol., 1984; 4(10): 1999-2009. PubMedID: 6390182.
    1. Distribution and lysis of weakly and strongly immunogenic malignant lymphoid cells in normal and immune mice: effects of prior exposure to heat or X-irradiation.
      Nawrocki JF, Look AT, Selwa JF, Haggis JR, Murphy WH.
      J. Natl. Cancer Inst., 1984; 72(5): 1085-94. PubMedID: 6585585.
    1. Continuous infusion high-dose cytosine arabinoside in refractory childhood leukemia.
      Ochs J, Sinkule JA, Danks MK, Look AT, Bowman WP, Rivera G.
      J. Clin. Oncol., 1984; 2(10): 1092-7. PubMedID: 6593435.
    1. New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia.
      Williams DL, Look AT, Melvin SL, Roberson PK, Dahl G, Flake T, Stass S.
      Cell, 1984; 36(1): 101-9. PubMedID: 6607116.
    1. Increased adenosine deaminase (ADA) activity and a shift from ADA-dependent to ADA-independent phases during T-cell activation: a paradox.
      Veit BC, Fishman M, Look T.
      J. Natl. Cancer Inst., 1984; 72(5): 1151-9. PubMedID: 6609265.
    1. Two-color flow cytometric measurement of DNA distributions of rat megakaryocytes in unfixed, unfractionated marrow cell suspensions.
      Jackson CW, Brown LK, Somerville BC, Lyles SA, Look AT.
      Blood, 1984; 63(4): 768-78. PubMedID: 6704539.
    1. Cellular DNA content as a predictor of response to chemotherapy in infants with unresectable neuroblastoma.
      Look AT, Hayes FA, Nitschke R, McWilliams NB, Green AA.
      N. Engl. J. Med., 1984; 311(4): 231-5. PubMedID: 6738617.
  30. 1983
    1. Effects of the epipodophyllotoxin VP-16-213 on cell cycle traverse, DNA synthesis, and DNA strand size in cultures of human leukemic lymphoblasts.
      Kalwinsky DK, Look AT, Ducore J, Fridland A.
      Cancer Res., 1983; 43(4): 1592-7. PubMedID: 6572554.
    1. Comparative cytotoxic and cytokinetic effects of the epipodophyllotoxins 4'-demethylepipodophyllotoxin-9-(4,6-O-2-ethylidene-beta-D-glucopyranoside) and 4'-demethylepipodophyllotoxin-9-(4,6-O-2-thenylidene-beta-D-glucopyranoside) and their metabolites on human leukemic lymphoblasts.
      Dow LW, Sinkule JA, Look AT, Horvath A, Evans WE.
      Cancer Res., 1983; 43(12): 5699-706. PubMedID: 6580063.
    1. Macrophage-mediated cytostatic activity blocks lymphoblast cell cycle progression independently in both G1 phase and S phase.
      Hamilton TA, Fishman M, Crawford G, Look AT.
      Cell. Immunol., 1983; 77(2): 233-41. PubMedID: 6850841.
  31. 1982
    1. Clinical and cell kinetic studies of the effects of the epipodophyllotoxin VP16-213 during therapy of refractory acute nonlymphocytic leukemia.
      Look AT, Dahl GV, Rivera G, Mauer AM.
      Cancer Chemother. Pharmacol., 1982; 7(2): 161-7. PubMedID: 6177437.
    1. Single-agent and combination chemotherapy with etoposide in the acute leukemias of childhood.
      Rivera G, Bowman WP, Look AT, Evans WE, Kalwinsky D, Dahl GV.
      Cancer Treat. Rev., 1982; 9: 53-7. PubMedID: 6181873.
    1. Cytokinetically based induction chemotherapy and splenectomy for childhood acute nonlymphocytic leukemia.
      Dahl GV, Kalwinsky DK, Murphy S, Look AT, Amadori S, Kumar M, Novak R, George SL, Mason C, Mauer AM, Simone JV.
      Blood, 1982; 60(4): 856-63. PubMedID: 6896834.
    1. Acute lymphocytic leukemia: biological markers of clinical response.
      Mauer AM, Bowman WP, Dow LW, Look AT, Williams D.
      J Cell Physiol Suppl, 1982; 1: 127-32. PubMedID: 6950939.
    1. Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia.
      Williams DL, Tsiatis A, Brodeur GM, Look AT, Melvin SL, Bowman WP, Kalwinsky DK, Rivera G, Dahl GV.
      Blood, 1982; 60(4): 864-71. PubMedID: 6956375.
    1. Sensitivity to macrophage-mediated cytostasis is cell cycle dependent.
      Hamilton TA, Fishman M, Crawford G, Look AT.
      Cell. Immunol., 1982; 69(2): 363-73. PubMedID: 7049409.
    1. Pharmacokinetics of Teniposide (VM26) and etoposide (VP16-213) in children with cancer.
      Evans WE, Sinkule JA, Crom WR, Dow L, Look AT, Rivera G.
      Cancer Chemother. Pharmacol., 1982; 7(2): 147-50. PubMedID: 7083455.
    1. Aneuploidy and percentage of S-phase cells determined by flow cytometry correlate with cell phenotype in childhood acute leukemia.
      Look AT, Melvin SL, Williams DL, Brodeur GM, Dahl GV, Kalwinsky DK, Murphy SB, Mauer AM.
      Blood, 1982; 60(4): 959-67. PubMedID: 7115962.
    1. Determination of the significance of in vitro blast cell [3H]thymidine labelling indices obtained initially and serially during induction therapy of acute non-lymphocytic leukemia.
      Murphy SB, Dahl GV, George SL, Karas J, Look AT, Simone JV, Mauer AM.
      Leuk. Res., 1982; 6(5): 639-48. PubMedID: 7154706.
  32. 1981
    1. Effective remission induction of refractory childhood acute nonlymphocytic leukemia by VP-16-213 plus azacitidine.
      Look AT, Dahl GV, Kalwinsky D, Senzer N, Mason C, Rivera G.
      Cancer Treat Rep, 1981; 65(11): 995-9. PubMedID: 6170431.
    1. Fatal Epstein-Barr virus infection in a child with acute lymphoblastic leukemia in remission.
      Look AT, Naegele RF, Callihan T, Herrod HG, Henle W.
      Cancer Res., 1981; 41(11): 4280-3. PubMedID: 6272972.
    1. Near-haploid acute lymphoblastic leukemia: a unique subgroup with a poor prognosis?
      Brodeur GM, Williams DL, Look AT, Bowman WP, Kalwinsky DK.
      Blood, 1981; 58(1): 14-9. PubMedID: 6940627.
    1. Computer simulation of the cellular immune response to malignant lymphoid cells: logic of approach, model design and laboratory verification.
      Look AT, Schriber TJ, Nawrocki JF, Murphy WH.
      Immunology, 1981; 43(4): 677-90. PubMedID: 7275173.
  33. 1980
    1. Osteosarcoma, fibrous dysplasia, and a chromosomal abnormality in a 3-year-old child.
      Brodeur GM, Caces J, Williams DL, Look AT, Pratt CB.
      Cancer, 1980; 46(5): 1197-201. PubMedID: 6938302.
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    1. The effect of natural and surgically constructed aortopulmonary shunts on hemodynamic function in tetralogy of Fallot.
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      Ann. Thorac. Surg., 1975; 20(5): 571-80. PubMedID: 1190889.