NEWS

January 2010 – Ligon lab and DFCI Neurooncology receive funding from $2.9M Ivy Foundation Early Phase Clinical Trials Consortium grant to evaluate molecular pathology signatures of response to novel targeted therapeutics in GBM patients. More...

November 2009 – Ligon lab identifies CRX as novel transcription factor target in retinoblastoma and rare brain cancer pineoblastoma. More...

October 2009 – Ligon Lab receives generous support from Sontag Foundation More...

The research of the Ligon laboratory is focused on understanding the links between stem and progenitor cell biology and the biology of Glioblastoma and a diverse array of other human brain cancers. Our studies combine insights from developmental biology, cancer genetics, and neuropathology to identify new diagnostic and therapeutic targets in brain tumors. Our work is especially oriented towards mapping the complex networks of transcription factor proteins which precisely control stem cell growth and the growth of cancer cells. The lab utilizes methods of stem cell biology, mouse transgenics, and molecular genetics to achieve these goals.

Another major goal of the lab is to advance the development of direct “human science” methods. There has been a recent explosion in the possibilities for direct study of human biology in science and decreased dependence on surrogate model systems to study disease. However these studies require direct study of human tissue systems using new techniques. These methods include the study of novel cell culture systems, development of ex vivo human model systems (slice culture), and application of advanced genomic methods to normal and cancer pathology states. These studies involve laboratory research as well as collaborative clinical-trial based research within Boston and other centers around the country.

The lab’s research is highly oriented towards real world translation of these findings into clinical diagnostic and therapeutic tools to help improve the lives of cancer patients.

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