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DFCI HMS Broad

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Recent Articles

Targeted DNA methylation in human cells using engineered dCas9-methyltransferases.
Xiong T, Meister GE, Workman RE, Kato NC, Spellberg MC, Turker F, Timp W, Ostermeir M, Novina CD.
Scientific Rep. 2017; 7(1):6732. PMID: 28751638, PDF

Prmt1-mediated translation regulation is a crucial vulnerability of cancer.
Hsu JH-R, Hubbell-Engler B, Adelmant G, Huang J, Joyce C, Vazquez F, Weir B, Montgomery P, Tsherniak A, Giacomelli A, Perry J, Trowbridge J, Fujiwara Y, Cowley G, Xie H, Kim W, Novina CD, Hahn W, Marto J, Orkin S.
Cancer Res. 2017. [Epub ahead of print]. PMID: 28655788

The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection.
Moffett HF, Cartwright ANR, Kim HJ, Godec J, Pyrdol J, Äijö T, Martinez GJ, Rao A, Lu J, Golub TR, Cantor H, Sharpe AH, Novina CD, Wucherpfennig KW.
Nat. Immunol. 2017; 18(7):791-799. PMID: 28530712

RATA: A method for high-throughput identification of RNA bound transcription factors.
Schmidt K, Buquicchio F, Carroll J, Distel RJ, Yoon CH, Novina CD.
J. Biol. Methods. 2017; 4(1), e67. Direct Link

Differential regulation of the melanoma proteome by eIF4A1 and eIF4E.
Joyce CE, Yanez, AG, Mori A, Yoda A, Carroll JS, Novina CD.
Cancer Res. 2017 Feb 1;77(3):613-622. PMID: 27879264

Bidirectional Crosstalk between patient-derived melanoma and cancer-associated fibroblasts promotes invasion and proliferation.
Izar B, Joyce C, Goff S, Cho NL, Shah PM, Sharma G, Li J, Ibrahim N, Gold J, Hodi FS, Garraway LA, Novina CD, Bertagnolli MM, Yoon CH.
Melanoma Res. 2016; Nov;29(6):656-668. PMID: 27482935

The lncRNA SLNCR1 mediates melanoma invasion through a conserved SRA1-like region.
Schmidt K, Joyce CE, Buquicchio F, Brown A, Ritz J, Distel RJ, Yoon CH, Novina CD.
Cell Reports. 2016; 15(9):2025-37. PMID: 27210747
This paper was also featured in a write up by Bio Century Innovations.

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8/S100A9.
Schneider RK, Schenone M, Kramann R, Ferreira MV, Joyce CE, Hartigan C, Beier F, Brümmendorf, TF, Gehrming U, Platzbecker U, Buesche G, Chen MC, Waters CS, Chen E, Chu LP, Novina CD, Lindsley RC, Carr SA, Ebert BL.
Nat. Med. 2016; 22(3): 288-297. PMID: 26878232

Unique patterns of protein sequence evolution and miRNA expression in the South American strong voltage electric eel.
Traeger LL, Volkening JD, Moffett H, Gallant JR, Chen PH, Novina CD, Phillips GN Jr, Anand R, Wells GB, Pinch M, Unguez GA, Albert JS, Zakon HH, Sussman MR, Samanta MP.
BMC Genomics. 2015; Mar 26;16:24. PMID: 25887781
* This manuscript was selected for Faculty of 1000

Genomic basis for the convergent evolution of electric organs.
Gallant JR, Traeger LL, Volkening JD, Moffett H, Chen PH, Novina CD, Phillips GN Jr, Anand R, Wells GB, Pinch M, Güth R, Unguez GA, Albert JS, Zakon HH, Samanta MP, Sussman MR.
Science. 2014; 344(6191):1522-1525. PMID: 24970089, PDF

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia.
Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, Brand M, Gutierrez A, Kelliher MA, Jamieson CH, von Boehmer H, Young RA, Look AT.
J Exp Med. 2013; 210(8):1545-1557. PMID: 23857984, PDF

Akt-mediated phosphorylation of argonaute2 downregulates cleavage and upregulates translational repression of microRNA targets.
Horman SR, Janas MM, Litterst C, Wang B, MacRae IJ, Sever MJ, Morrissey DV, Graves P, Luo B, Umesalma S, Qi HH, Miraglia LJ, Novina CD, Orth AP.
Mol. Cell. 2013; 50: 356-367. PMID: 23603119, PDF

Reduced expression of ribosomal proteins relieves microRNA-mediated repression.
Janas MM, Wang E, Love T, Harris AS, Stevenson K, Semmelmann K, Shaffer JM, Chen P-H, Doench JG, Yerramilli SVBK, Neuberg DS, Iliopoulos D, Housman DE, Burge CB, and Novina CD.
Mol Cell. 2012; 46: 171-186. PMID: 22541556, PDF

Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins.
Janas, MM, Wang B, Harris AS, Aguiar M, Shaffer J.M, Yerramilli SVBK, Behlke MA, Wucherpfennig KW, Gygi SP, Gagnon E, and Novina CD.
RNA, 2012; 18(11): 2041-2055. PMID: 23019594, PDF, Supplement

Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.
Li X, Sanda T, Look AT, Novina CD*, von Boehmer H.
J Exp Med. 2011. Apr 11;208(4):663-75. Epub 2011 Apr 4. PMID: 21464222, PDF

microRNA expression profiling identifies activated B cell status in chronic lymphocytic leukemia cells.
Li S, Moffett HF, Lu J, Werner L, Zhang H, Ritz J, Neuberg D, Wucherpfennig KW, Brown JR, Novina CD.
PLoS ONE. 2011. 2011; Mar 8;6(3):e16956. PMID: 21408091, PDF

Feed-forward microprocessing and splicing activities at a microRNA-containing intron.
Janas MM, Khaled M, Schubert S, Bernstein JG, Golan D, Veguilla RA, Fisher DE, Shomron N, Levy C, and Novina CD.
PLoS Genet. 2011. (7)10:e1002330. PMID: 22028668, PDF

New insights into the biology of melanomas using a microRNA tool-KIT.
Novina CD.
Cell Cycle. 2011; 10(17). PMID: 21869597, PDF

Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. 
Levy C,  Khaled M, Iliopoulos D, Janas M, Schubert S, Pinner S, Chen P-H, Li S, Fletcher A,Yokoyama S, Scott KL, Garraway LA, Song JS, Granter SR, Turley SJ, Fisher DE, and Novina CD.
Mol. Cell. 2010 Dec 10;40(5):841-9. Epub 2010 Nov 25. PMID: 21109473 PDF N&V
* This manuscript was selected for Faculty of 1000

Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins.
Wang B, Li S, Qi HH, Chowdhury D, Shi Y, and Novina CD.
Nat. Struct. Mol. Biol. 2009; 16(12):1259-1266. PMID: 19946268 PDF Supplement
* This manuscript was selected for Faculty of 1000

Comprehensive profiling of EBV microRNAs in nasopharyngeal carcinoma.
Cosmopoulos K, Pegtel M, Hawkins J, Moffett H, Novina CD, Middeldorp J, Thorley-Lawson DA.
J. Virology 2008; 83(5):2357-2367. PMID: 19091858 PDF

microRNA expression in the biology, prognosis and therapy of Waldenstrom macroglobulinemia.
Roccaro AM, Sacco A, Chen C, Runnels J, Leleu X, Azab F, Azab AK, Jia X, Ngo HT, Melhem MR, Burwick N, Varticovski L, Novina CD, Rollins BJ, Anderson KC, Ghobrial IM.
Blood 2008; 113(18):4391-4402. PMID: 19074725 PDF

MicroRNA-repressed mRNAs contain 40S but not 60S components.
Wang B, Yanez A, Novina CD.
Proc. Natl. Acad. Sci. U S A 2008 Apr 8;105(14):5343-8. PMID: 18390669 PDF Supplement
The Editorial Board of the Proceedings of the National Academy of Sciences reported that this work “is one of our 30 most-read papers online during the month of April 2008 Most read.
This paper was also featured in Cell’s Leading Edge series.

Chronic Lymphocytic Leukemia Requires BCL2 to Sequester Prodeath BIM.
Del Gazio Moore V, Brown JR, Certo M, Love TM, Novina CD, Letai A.
J Clin. Invest. 2007; 117(1):112-21. PMID: 17200714 PDF
* This manuscript was selected for Faculty of 1000

Opposing Functions of TFII-I Spliced Isoforms in Growth Factor-Induced Gene Expression.
Hakre S, Tussie-Luna MI, Ashworth T, Novina CD, Settleman J, Sharp PA, Roy AL.
Mol Cell. 2006; 24(2):301-308. PMID: 17052463

Recapitulation of short RNA-directed translational gene silencing in vitro.
Wang B, Love TM, Call ME, Doench JG, Novina CD.
Mol Cell. 2006 May 19;22(4):553-60. PMID: 16713585 PDF Supplement

Genetic analysis of the subunit organization and function of the COG complex: Studies of COG5 and COG7 deficient mammalian cells.
Oka T, Vasile E, Perman M, Novina CD, Dykxhoorn DM, Ungar D, Hughson FM, and Krieger M.
J. Biol. Chem. 2005; 280:38 32736-45. PMID: 16051600 PDF

Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages.
Song E, Lee S-K, Dykxhoorn DM, Novina CD, Zhang D, Crawford K, Cerny J, Sharp PA, Lieberman J, Manjunath N, Shankar P.
J. Virol. 2003; 77: 7174-81. PMID: 12805416 PDF

Lentivirus-delivered stable gene silencing by RNAi in primary cells.
Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen ISY, Hahn WC, Sharp PA, Weinberg RA, Novina CD.
RNA 2003; 9: 493-501. PMID: 12649500 PDF

Cleaving the oxidative repair protein ApeI enhances cell death mediated by granzyme A.
Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J.
Nat. Immunol. 2003; 4: 145-153. PMID: 12524539

siRNA-directed inhibition of HIV-1 infection.
Novina CD, Murray MF, Dykxhoorn DM, Beresford PJ, Riess J, Lee S-K, Collman RG, Lieberman J, Shankar P, Sharp PA.
Nat. Med. 2002; 8: 681-686. PMID: 12042777 PDF N&V NEJM

Reviews, Chapters, Editorials, News and Views

miR-155 in acute myeloid leukemia: not miR-ly a prognostic marker.
Joyce CE, Novina CD.
J Clin Oncol. 2013 31(17):2219-2221. PMID: 23650419, PDF

Not lost in translation: stepwise regulation of microRNA targets.
Janas MM and Novina CD.
EMBO J. 2012; 31(11):2446-2447. PMID: 22522704, PDF

New insights into the biology of melanomas using a microRNA tool-KIT
Novina CD
Cell Cycle 2011; 10 (17):2828-2829. PMID: 21869597 PDF

The chicken or the egg: microRNA-mediated regulation of mRNA translation or mRNA stability.
Omer AD, Janas MM, Novina CD.
Mol Cell. 2009 Sep 24;35(6):739-740. PMID: 19782024 PDF

RNA-Directed Therapy: The Next Step in the miRNA Revolution.
Novina CD, Chabner BA.
Oncologist. 2008 Jan;13(1):1-3. PMID: 18245006 PDF

Not miR-ly small RNAs: big potential for microRNAs in therapy.
Love TM, Moffett HF, Novina CD.
J. Allergy Clin. Immunol. 2008 Feb;121(2):309-19. PMID: 18269923 PDF

A small RNA makes a Bic difference.
Moffett, HF, Novina CD.
Genome Biol. 2007; 8(7):221. PMID: 17666120 PDF

Analysis of microRNA effector functions in vitro.
Wang B, Doench JG, Novina CD.
Methods. 2007; 43(2):91-104. PMID: 17889795 PDF

RNAi & RNA-based regulation of immune system function
Chowdhury D, and Novina CD
Adv. Immunol. 2005; 88:267-292. PMID: 16227093 PDF

Potential roles for short RNAs in lymphocytes.
Chowdhury D, and Novina CD
Immunol. Cell Biol. 2005; 83, 210-10. PMID: 15877596 PDF

RNA Interference.
Doench, JD and Novina CD.
Encyclopedia of Molecular Cell Biology and Molecular Medicine (EMCBMM) entry: 2005;12: 527-554. PDF

Therapeutic potential of RNA interference.
Novina, CD.
Biomed. Pharmacother. 2004; 58:270 PDF

The RNAi revolution.
Novina CD, and Sharp PA.
Nature 2004; 430:161-164. PMID: 15241403 PDF
“Fast Breaking Paper” Thomson-ISI determined “The RNAi revolution” to be one of the most cited recent papers in the field of Molecular Biology, August, 2005.

Killing the messenger: short RNAs that silence gene expression.
Dykxhoorn DM, Novina CD, and Sharp PA.
Nat. Rev. Mol. Cell Biol. 2003; 4: 457-467. PMID: 12778125 PDF

Methods for studying the biochemical properties of an Inr element binding protein: TFII-I.
Novina CD, Cheriyath V, Denis MC, Roy AL.
Methods: Companion to Methods Enzymol. 1997; 12: 254-263. PMID: 9237169

Other PI Articles

Human Mullerian-inhibiting substance promoter contains a functional TFII-I binding initiator.
Morikawa N, Clarke TR, Novina CD, Watanabe K, Haqq C, Weiss M, Roy AL, Donahoe PK.
Biol. Reprod. 2000; 63: 1075-1083. PMID: 10993829

Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton’s tyrosine kinase.
Novina CD, Kumar S, Bajpai U, Cheriyath V, Zhang K, Pillai S, Wortis HH, Roy AL.
Mol. Cell. Biol. 1999; 19: 5014-5024. PMID: 9837922

TFII-I regulates Vb promoter activity through an initiator element.
Cheriyath V, Novina CD, Roy AL.
Mol. Cell. Biol. 1998; 18: 4444-4454. PMID: 9671454

Regulation of TFII-I activity by phosphorylation.
Novina CD, Cheriyath V, Roy AL.
J. Biol. Chem. 1998; 273: 33443-33448. PMID: 9837922

Cloning of an Inr- and E-box binding protein, TFII-I that interacts physically and functionally with USF1.
Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG.
EMBO J. 1997; 23: 7091-7104. PMID: 9384587

A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I.
Greuneberg DA, Henry RW, Brauer A, Novina CD, Cheriyath V, Roy AL, Gilman M.
Genes Dev. 1997; 11: 2482-2493. PMID: 9334314

NF-kB homodimer binding within the HIV-1 initiator region and interactions with TFII-I.
Montano MA, Kripke K, Novina CD, Achacoso P, Herzenberg LA, Roy AL, and Nolan GP.
Proc. Natl. Acad. Sci., USA 1996; 93: 12376-12381 PMID: 8901589

TFII-I is required for transcription of the naturally TATA-less but Initiator-Containing Vb promoter.
Manzano-Winkler B, Novina CD, Roy AL.
J. Biol. Chem. 1995; 271: 12076-12081. PMID: 8662630

Core promoters and transcriptional control.
Novina CD, and Roy AL.
Trends Genet. 1996; 12:351-355. PMID: 8855664

* Faculty of 1000 (F1000) places published work in a of library of the top 2% of published articles in biology and medicine.