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The Novina Lab studies the role of non-coding RNAs in oncogenesis, bone marrow failure syndromes, and tumor immunotherapy. We implement and develop advanced tools to gain insights into basic biological processes. By utilizing these tools in the context of diseases, we attempt to accelerate translation of these insights and tools into novel therapies. The Novina Lab is a highly collaborative environment. We have many clinical collaborators who provide insight on how to leverage tools in order to directly address questions relevant to current standard of care practices. Basic biological questions and their application for therapy include:

(1) Discovery of the lncRNA dependent interactomes in cancers
(2) Molecular pathogenesis of the ribosomopathies SDS and DBA
(3) Targeted DNA methylation and epigenetic regulation of gene expression
(4) Engineering T cells for immunotherapy

Postdoctoral position is available to lead a project focused on the biology and mechanisms of disease-relevant long non-coding RNAs (lncRNAs). The ideal candidate will have experience with RNA and protein biochemistry and molecular biology, and a desire to develop the translational potential of lncRNAs. He or she will integrate computational analyses, systems approaches, and advanced biochemical technologies to understand lncRNA biology ex vivo and in vivo. This position will work closely with other researchers and clinicians towards these goals. Interested candidates should contact Carl Novina (carl_novina@dfci.harvard.edu) for details.

Links related to Novina Lab research
DFCI Researcher Profile
CIA Faculty Profile
DF/HCC Member Profile
BBS Rotation Manual Profile
Immunology Rotation Manual Profile
Office of Research and Technology Ventures
Dr. Novina’s Youtube video on epigenetic reprogramming
Dr. Novina wins the 2015 NIH Directors’ Pioneer Award
Dr. Novina’s Interviews with International Innovation in 2013 and 2014

siRNA