Alan D. D'Andrea, M.D.



Expanded roles of the Fanconi anemia pathway in preserving genomic stability.
Kee Y, D'Andrea AD.
Genes Dev. 2010 Aug 15;24(16):1680-94.

The FANCM/FAAP24 Complex is Required for the DNA Interstrand Crosslink-Induced Checkpoint Response.
Huang M, Kim JM, Shiotani B, Yang K, Zou L, D’Andrea AD.
Mol Cell. 2010 Jul 30;39(2):259-268.

Hematopoietic Stem Cell Defects in Mice with Deficiency of Fancd2 or Usp1.
Parmar, K, JM Kim, SM Sykes, A Shimamura, P Stuckert, K Zhu, A Hamilton, MK DeLoach, JL Kutok, K Akashi, DG Gilliland, AD D’Andrea.
Stem Cells. 2010 Jul;28(7):1186-95.

RAD18-dependent recruitment of SNM1A to DNA repair complexes by a Ubiquitin-binding zinc finger.
Yang K, Moldovan GL, D'Andrea AD.
J Biol Chem. 2010 Jun 18;285(25):19085-91

A.D. WDR20 regulates activity of the USP12/UAF1 deubiquitinating enzyme complex.
Kee, Y., Yang, K., Cohn, M.A., Haas, W., Gygi, S.P., D’Andrea, A.D.
J Biol Chem. 2010 Apr 9;285(15):11252-7.

Susceptibility pathways in Fanconi's anemia and breast cancer.
D'Andrea AD.
2010 N Engl J Med 362: 1909-1919.


DNA polymerase POLN participates in crosslink repair and homologous recombination.
Moldovan, G. L., Madhavan, M.V., Mirchandani, K.D., McCaffrey, R.M., Vinciguerra, P., D’Andrea, A.D.
Mol Cell Biol (2009).

FANCD2 Hurdles the DNA Interstrand Crosslink.
Moldovan, G. L. & D'Andrea, A.
Cell. 139, 3-5 (2009).

Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.
Kim, J. M., Parmar, K., Huang, M., Weinstock, D.M., Ruit, C.A., Kutok, J.L., D’Andrea, A.D.
Dev Cell 16, 314-320 (2009). NIHMS97012

D'Andrea, A. D. Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis.
Kee, Y., Kim, J. M. & D'Andrea, A. D.
Genes Dev 23, 555-560

Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage.
Johnson, N., Cai, D., Kennedy, R.D., Pathania, S., Arora, M., Li, Y.C., D'Andrea, A.D., Parvin, J.D., and Shapiro, G.I.
Mol Cell 35, 327-339.(2009)

UAF1 is a Regulatory Subunit of Multiple Deubiquitinating Enzyme Complexes.
Cohn MA, Y Kee, W Haas, SP Gygi and AD D’Andrea.
J Biol Chem. Feb 20;284(8):5343-51, 2009.


Chromatin Recruitment of DNA Repair Proteins: Lessons from the Fanconi Anemia and Double Strand Break Repair Pathways.
Cohn MA and AD D’Andrea.
Mol Cell. 32: 306-312, 2008.

Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.
Sidi, S., T. Sanda, R. D. Kennedy, A. T. Hagen, C. A. Jette, R. Hoffmans, J. Pascual, S. Imamura, S. Kishi, J. F. Amatruda, J. P. Kanki, D. R. Green, A. A. D'Andrea, and A. T. Look.
Cell 133:864-77 (2008)

The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly.
Mirchandani, K. D., R. M. McCaffrey, and A. D. D'Andrea.
DNA Repair (Amst) 7:902-11, 2008.

Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24.
Kim, J. M., Y. Kee, A. Gurtan, and A. D. D'Andrea.
Blood 111:5215-22, 2008.


AD. A UAF1-containing multisubunit protein complex regulates the Fanconi Anemia Pathway.
Cohn MA, Kowal P, Yang K, Haas W, Huang T, Gygi SP, D’Andrea AD.
MolCell 28:786-797, 2007.

Free in PMC Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.
Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau LA, Shimamura A, D'Andrea AD.
J Clin Invest. 2007 May;117(5):1440-9. Epub 2007 Apr 12. Pubmed ID: 17431503

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.
Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER 3rd, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJ.
Cell. 2007 Apr 20;129(2):289-301. Epub 2007 Apr 5. Pubmed ID: 17412408

Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway.
Wang X, Kennedy RD, Ray K, Stuckert P, Ellenberger T, D'Andrea AD.
Mol Cell Biol. 2007 Apr;27(8):3098-108. Epub 2007 Feb 12. Pubmed ID: 17296736

The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents.
Chen CC, Taniguchi T, D'Andrea A.
J Mol Med. 2007 May;85(5):497-509. Epub 2007 Jan 13. Pubmed ID: 17221219

Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex.
Kowal P, Gurtan AM, Stuckert P, D'Andrea AD, Ellenberger T.
J Biol Chem. 2007 Jan 19;282(3):2047-55. Epub 2006 Nov 1. Pubmed ID: 17082180


Genetic analysis of ionizing radiation-induced mutagenesis in Saccharomyces cerevisiae reveals TransLesion Synthesis (TLS) independent of PCNA K164 SUMOylation and ubiquitination.
Chen CC, Motegi A, Hasegawa Y, Myung K, Kolodner R, D'Andrea A.
DNA Repair (Amst). 2006 Dec 9;5(12):1475-88. Epub 2006 Sep 20. Pubmed ID: 16990054

Free in PMC Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance.
Ho GP, Margossian S, Taniguchi T, D'Andrea AD.
Mol Cell Biol. 2006 Sep;26(18):7005-15. Pubmed ID: 16943440

UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.
Machida YJ, Machida Y, Chen Y, Gurtan AM, Kupfer GM, D'Andrea AD, Dutta A.
Mol Cell. 2006 Aug;23(4):589-96. Pubmed ID: 16916645

DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes.
Kennedy RD, D'Andrea AD.
J Clin Oncol. 2006 Aug 10;24(23):3799-808. Review. Pubmed ID: 16896009

The Fanconi anemia/BRCA pathway: a coordinator of cross-link repair.
Mirchandani KD, D'Andrea AD.
Exp Cell Res. 2006 Aug 15;312(14):2647-53. Epub 2006 Jun 21. Review. Pubmed ID: 16859679

Dedicated to the core: understanding the Fanconi anemia complex.
Gurtan AM, D'Andrea AD.
DNA Repair (Amst). 2006 Sep 8;5(9-10):1119-25. Epub 2006 Jun 19. Review. Pubmed ID: 16784902

Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway.
Chirnomas D, Taniguchi T, de la Vega M, Vaidya AP, Vasserman M, Hartman AR, Kennedy R, Foster R, Mahoney J, Seiden MV, D'Andrea AD.
Mol Cancer Ther. 2006 Apr;5(4):952-61. Pubmed ID: 16648566

Regulation of DNA repair by ubiquitylation.
Huang TT, D'Andrea AD.
Nat Rev Mol Cell Biol. 2006 May;7(5):323-34. Review. Pubmed ID: 16633336

Regulation of monoubiquitinated PCNA by DUB autocleavage.
Huang TT, Nijman SM, Mirchandani KD, Galardy PJ, Cohn MA, Haas W, Gygi SP, Ploegh HL, Bernards R, D'Andrea AD.
Nat Cell Biol. 2006 Apr;8(4):339-47. Epub 2006 Mar 12. Pubmed ID: 16531995

Molecular pathogenesis of Fanconi anemia: recent progress.
Taniguchi T, D'Andrea AD.
Blood. 2006 Jun 1;107(11):4223-33. Epub 2006 Feb 21. Review. Pubmed ID: 16493006

DNA damage responses and their many interactions with the replication fork.
Andreassen PR, Ho GP, D'Andrea AD.
Carcinogenesis. 2006 May;27(5):883-92. Epub 2006 Feb 20. Review. Pubmed ID: 16490739

The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly.
Gurtan AM, Stuckert P, D'Andrea AD.
J Biol Chem. 2006 Apr 21;281(16):10896-905. Epub 2006 Feb 10. Pubmed ID: 16474167

Free in PMC Natural gene therapy in monozygotic twins with Fanconi anemia.
Mankad A, Taniguchi T, Cox B, Akkari Y, Rathbun RK, Lucas L, Bagby G, Olson S, D'Andrea A, Grompe M.
Blood. 2006 Apr 15;107(8):3084-90. Epub 2006 Jan 5. Pubmed ID: 16397136

The Fanconi Anemia/BRCA pathway: new faces in the crowd.
Kennedy RD, D'Andrea AD. Genes Dev. 2005 Dec 15;19(24):2925-40. Review. PMID: 16357213

Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients.
Howlett NG, Scuric Z, D'Andrea AD, Schiestl RH. DNA Repair (Amst). 2006 Feb 3;5(2):251-7. Epub 2005 Nov 22. PMID: 16309973


Direct DNA binding activity of the fanconi anemia D2 protein.
Park WH, Margossian S, Horwitz AA, Simons AM, D'Andrea AD, Parvin JD. J Biol Chem 2005 Apr 23;. Published 2005 Apr 23. Pubmed ID: 15849361.

The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability.
Howlett NG, Taniguchi T, Durkin SG, D'Andrea AD, Glover TW. Mol Cell 2005 Feb 4;17(3):331-9. Published 2005 Mar 1. Pubmed ID: 15661754.

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.
Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R. Published 2005 Feb 4. Pubmed ID: 15694335.

Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin.
Montes de Oca R, Andreassen PR, Margossian SP, Gregory RC, Taniguchi T, Wang X, Houghtaling S, Grompe M, D'Andrea AD. Blood 2005 Feb 1;105(3):1003-9. Epub 2004 Sep 28. Published 2005 Feb 1. Pubmed ID: 15454491.

Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway.
Soulier J, Leblanc T, Larghero J, Dastot H, Shimamura A, Guardiola P, Esperou H, Ferry C, Jubert C, Feugeas JP, Henri A, Toubert A, Socie G, Baruchel A, Sigaux F, D'Andrea AD, Gluckman E. Published 2005 Feb 1. Pubmed ID: 15383454.

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair.
Nakanishi K, Yang YG, Pierce AJ, Taniguchi T, Digweed M, D'Andrea AD, Wang ZQ, Jasin M. Proc Natl Acad Sci U S A 2005 Jan 25;102(4):1110-5. Epub 2005 Jan 13. Published 2005 Jan 25. Pubmed ID: 15650050.


ATR couples FANCD2 monoubiquitination to the DNA-damage response.
Andreassen PR, D'Andrea AD, Taniguchi T. Genes Dev 2004 Aug 15;18(16):1958-63. Published 2004 Aug 15. Pubmed ID: 15314022.

The interplay of Fanconi anemia proteins in the DNA damage response.
Wang X, D'Andrea AD. DNA Repair (Amst) 2004 Aug-Sep;3(8-9):1063-9. Published 2004 Aug-Sep. Pubmed ID: 15279794.

Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.
Wang X, Andreassen PR, D'Andrea AD. Mol Cell Biol 2004 Jul;24(13):5850-62. Published 2004 Jul. Pubmed ID: 15199141.

Association of biallelic BRCA2/FANCD1 mutations with spontaneous chromosomal instability and solid tumors of childhood.
Hirsch B, Shimamura A, Moreau L, Baldinger S, Hag-alshiekh M, Bostrom B, Sencer S, D'Andrea AD. Published 2004 Apr 1. Pubmed ID: 14670928.


Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis.
Liu TX, Howlett NG, Deng M, Langenau DM, Hsu K, Rhodes J, Kanki JP, D'Andrea AD, Look AT. Dev Cell 2003 Dec;5(6):903-14. Published 2003 Dec. Pubmed ID: 14667412.
Subtyping of Fanconi anemia patients: implications for clinical management.
Shimamura A, D'Andrea AD. Blood 2003 Nov 1;102(9):3459. Published 2003 Nov 1. Pubmed ID: 14568911.

The Fanconi road to cancer.
D'Andrea AD. Published 2003 Aug 15. Pubmed ID: 12893780.

Menin associates with FANCD2, a protein involved in repair of DNA damage.
Jin S, Mao H, Schnepp RW, Sykes SM, Silva AC, D'Andrea AD, Hua X. Cancer Res 2003 Jul 15;63(14):4204-10. Published 2003 Jul 15. Pubmed ID: 12874027.
The Fanconi Anemia/BRCA signaling pathway: disruption in cisplatin-sensitive ovarian cancers.
D'Andrea AD. Cell Cycle 2003 Jul-Aug;2(4):290-2. Published 2003 Jul-Aug. Pubmed ID: 12851475.

Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2.
Ikeda H, Matsushita M, Waisfisz Q, Kinoshita A, Oostra AB, Nieuwint AW, De Winter JP, Hoatlin ME, Kawai Y, Sasaki MS, D'Andrea AD, Kawakami Y, Joenje H. Cancer Res 2003 May 15;63(10):2688-94. Published 2003 May 15. Pubmed ID: 12750298.

Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors.
Taniguchi T, Tischkowitz M, Ameziane N, Hodgson SV, Mathew CG, Joenje H, Mok SC, D'Andrea AD. Nat Med 2003 May;9(5):568-74. Epub 2003 Apr 7. Published 2003 May. Pubmed ID: 12692539.

The Fanconi anaemia/BRCA pathway.
D'Andrea AD, Grompe M. Nat Rev Cancer 2003 Jan;3(1):23-34. Published 2003 Jan. Pubmed ID: 12509764.


A novel diagnostic screen for defects in the Fanconi anemia pathway.
Shimamura A, de Oca RM, Svenson JL, Haining N, Moreau LA, Nathan DG, D'Andrea AD. Blood 2002 Dec 15;100(13):4649-54. Epub 2002 Aug 29. Published 2002 Dec 15. Pubmed ID: 12393398.

Interaction of FANCD2 and NBS1 in the DNA damage response.
Nakanishi K, Taniguchi T, Ranganathan V, New HV, Moreau LA, Stotsky M, Mathew CG, Kastan MB, Weaver DT, D'Andrea AD. Nat Cell Biol 2002 Dec;4(12):913-20. Published 2002 Dec. Pubmed ID: 12447395.

Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants.
Adachi D, Oda T, Yagasaki H, Nakasato K, Taniguchi T, D'Andrea AD, Asano S, Yamashita T. Hum Mol Genet 2002 Dec 1;11(25):3125-34. Published 2002 Dec 1. Pubmed ID: 12444097.

S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.
Taniguchi T, Garcia-Higuera I, Andreassen PR, Gregory RC, Grompe M, D'Andrea AD. Blood 2002 Oct 1;100(7):2414-20. Published 2002 Oct 1. Pubmed ID: 12239151.

The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC.
Taniguchi T, D'Andrea AD. Blood 2002 Oct 1;100(7):2457-62. Published 2002 Oct 1. Pubmed ID: 12239156.

Biallelic inactivation of BRCA2 in Fanconi anemia.
Howlett NG, Taniguchi T, Olson S, Cox B, Waisfisz Q, De Die-Smulders C, Persky N, Grompe M, Joenje H, Pals G, Ikeda H, Fox EA, D'Andrea AD. Science 2002 Jul 26;297(5581):606-9. Epub 2002 Jun 13. Published 2002 Jul 26. Pubmed ID: 12065746.

Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.
Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim ST, Lane WS, Kastan MB, D'Andrea AD. Cell 2002 May 17;109(4):459-72. Published 2002 May 17. Pubmed ID: 12086603.