Publications

Qianben Wang,Wei Li,Yong Zhang ,Xin Yuan, Kexin Xu, Jindan Yu, Zhong Chen, Rameen Beroukhim, Hongyun Wang, Mathieu Lupien, Tao Wu, Meredith M. Regan, Clifford A. Meyer, Jason S. Carroll, Arjun Kumar Manrai, Olli A. Jänne, Steven P. Balk, Rohit Mehra, Bo Han, Arul M. Chinnaiyan, Mark A. Rubin, Lawrence True, Michelangelo Fiorentino, Christopher Fiore, Massimo Loda, Philip W. Kantoff, X. Shirley Liu, and Myles Brown. Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer. Cell (2009) 138, 245-256. [Download PDF] [Supplemental Material] [Link to Data]

Eeckhoute J, Lupien M and Brown M. Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers. Genome Research (2009) 19: 372-380.[Download PDF] [Supplemental Material]

Krum, Susan A., Gustavo A Miranda-Carboni, Lupien M, Eeckhoute J, Carroll JS, and Brown M. Unique ERalpha Cistromes Control Cell Type-Specific Gene Regulation. Mol Endo (2008) 22(11), 2393-2406.[Download PDF]

Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W, Carroll JS, Liu XS and Brown MA. FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription. Cell (2008) 132,958-970. [Download PDF]

Krum, Susan A., Gustavo A Miranda-Carboni, Peter V. Hauschka, Jason S. Carroll, Timothy F. Lane, Leonard P.Freedmanand Myles Brown. Estrogen Protects Bone by Inducing Fas Ligand in Osteoblasts to Regulate Osteoclast Survival. The EMBO Journal (2008) 27, 535–545.[Download PDF]

Wang Q, Li W, Liu XS, Carroll JS, Janne OA, Keeton EK, Chinnaiyan AM, Pienta KJ, Brown M. A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol Cell. 2007 Aug 3;27(3):380-92 [Download PDF] [Link to Raw Data]

Eeckhoute J, Keeton EK, Lupien M, Krum SA, Carroll JS, and Brown M. Positive Cross-Regulatory Loop Ties GATA-3 to Estrogen Receptor A Expression in Breast Cancer. Cancer Res. 2007 67: (13) 6477-6483. [Download PDF]

Durand M, Kolpak A, Farrell T, Elliott NA,Shao W, Brown M, Volkert MR. The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins. BMC Cell Biol. 2007 Mar 28;8:13. [Download PDF]

Torres-Arzayus MI, Yuan J, DellaGatta JL, Lane H, Kung AL, Brown M. Targeting the AIB1 oncogene through mammalian target of rapamycin inhibition in the mammary gland. Cancer Res. 2006 Dec 1;66(23):11381-8. [Download PDF]

Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS,Keeton EK, Fertuck KC,Hall GF, Wang Q, Bekiranov S, Sementchenko V, FoxEA, Silver PA, Gingeras TR, Liu XS, Brown M. Genome-wide analysis of estrogen receptor binding sites. Nat Genet. 2006; 38:1289-1297. [Download PDF] [Link to datasets] [load data in UCSC genome browser]

Jérôme Eeckhoute, Jason S. Carroll, Timothy R. Geistlinger, Maria I. Torres-Arzayus, and Myles Brown. A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer. Genes and Development 2006; 20: 2513–2526. Download PDF.

Carroll JS and Brown M. Estrogen receptor target gene: an evolving concept. Mol Endocrinology 2006; 8: 1707-14. Download PDF.

Wang Q, Carroll JS and Brown M. Spatial and Temporal Recruitment of Androgen
Receptor and Its Coactivators Involves Chromosomal Looping and Polymerase Tracking. Molecular Cell 2005; 19: 631–642. Download PDF

Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M. Chromosome-Wide Mapping of Estrogen Receptor Binding Reveals Long-Range Regulation Requiring the Forkhead Protein FoxA1. Cell 2005; 122(1): 33-43. [Download PDF] [Link to datasets]

Keeton EK and Brown M. Cell Cycle Progression Stimulated by Tamoxifen-
Bound Estrogen Receptor- and Promoter-Specific Effects in Breast Cancer Cells Deficient in N-CoR and SMRT. Molecular Endocrinology 2005; 19(6):1543–1554. Download PDF

Torres-Arzayus M., Font de Mora J., Yuan J., Vazquez F., Bronson R., Rue M., Sellers W., Brown M. High Tumor Incidence and Activation of the PI3K/AKT Pathway in Transgenic Mice define AIB1 as an Oncogene. Cancer Cell 2004, 6: 263-274. Download PDF

Shao W, Keeton EK, McDonnell DP, Brown M. Coactivator AIB1 links estrogen receptor transcriptional activity and stability. PNAS. 2004; 101(32):11599-604. Download PDF

Shao W, Brown M. Advances in Estrogen receptor Biology: Prospects for improvements in targeted Breast Cancer Therapy. Review. Breast Cancer Res. 2004; 6(1): 39-52. Download PDF

Hestermann E., Brown M. Agonist and chemopreventive ligands induce differential trancriptional cofactor recruitment by aryl hardrocarbon receptor. Mol. Cell Biol. 2003; 23(21):7920-7925. Download PDF

Shang Y, Brown M. Molecular determinants for the tissue specificity of SERMs. Science 2002; 295: 2465-2468. Download PDF

Shang Y, Myers M, Brown M. Formation of the androgen receptor transcription complex. Molecular Cell 2002; 9: 601-610. Download PDF. Erratum .

Shao W, Halachmi S, Brown M. ERAP140, a conserved tissue-specific receptor coactivator. Mol. Cell Biol. 2002; 22(10): 3358-3372. Download PDF

DiRenzo J, Signoretti S, Nakamura N,Rivera-Gonzalez R, Sellers WR, Loda M, Brown M. Growth factor requirement and basal phenotype of immortalized mammary epithelial cells. Cancer Res. 2002; 62:89-98. Download PDF

Yahata T, Shao W, Endoh H, Hur J, Coser KR, Sun H, Ueda Y, Kato S, Isselbacher KJ, Brown M, Shioda T. Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein. Genes Dev. 2001; 15:2598-2612. Download PDF

Rebbeck TR, Wang Y, Kantoff PW, Krithivas K, Neuhausen S, Godwin AK, Daly MB, Narod SA, Brunet J-S, Vesprini D, Garber JE, Lynch HT, Weber BL, Brown M. Modification of BRCA-1 and BRCA-2 associated breast cancer risk by AIB1 genotype and reproductive history Cancer Res 2001; 61:5420-5424. download pdf

Jones GB, Hynd G, Wright JM, Purohit A,Plourde II GW, Huber RS, Matthews JE, Li A, Kilgore MW, Bubley GJ, Yancisin M, Brown M. Target directed enediynes J. Org. Chem. 2001; 66(11): 3688-3695. download pdf

Planas-Silva MD, Shang Y, Donaher JL, Brown M, Weinberg RA AIB1 enhances estrogen dependent induction of Cyclin D1 promoter. Cancer Res. 2001; 61(10): 3858-62. download pdf

Shang Y, Hu X, Lazar MA, DiRenzo, J, Brown M. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription.Cell 2000 Dec; 103:843-852. download pdf.

DiRenzo, J, Shang, Y, Phalen, M, Sif, S, Myers, M, Kingston, R, Brown, M. BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. Mol Cell Biol 2000 Oct; 20(20):7541-7549 download pdf.

Carroll, RS, Brown, M, Zhang, J, DiRenzo, J, Font de Mora, J, Black, PM. Expression of a subset of steroid receptor cofactors is associated with progesterone receptor expression in meningiomas. Clin Cancer Res 2000 Sep; 6:3570-3575 PubMed abstract.

Haiman CA, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Speizer FE, Brown M, Hunter DJ. A polymorphic repeat in AIB1 does not alter breast cancer risk. Breast Cancer Res 2000 Jun19; 2:378-385. download pdf.

Font de Mora, J, Brown, M. AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Mol Cell Biol 2000 Jul 15;20(14):5041-5047 download pdf.

Jones GB, Wright JM, Hynd G, Wyatt JK, Yancisin M, Brown M. Library screening allows rapid identification of bioactive enediynes. Org Lett 2000 Jun 29;2(13):1863-1866 download pdf.

Poelzl G, Kasai Y, Mochizuki N, Shaul PW, Brown M, Mendelsohn ME. Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2836-9 download pdf.

Platz EA, Giovannucci E, Brown M, Cieluch C, Shepard TF, Stampfer MJ, Kantoff PW. Amplified in Breast Cancer-1Gultamine Repeat and Prostate Cancer Risk. The Prostate Journal 2000, 2(1): 27-32.

Krithivas K, Yurgalevitch S, Mohr B, Wilcox C, Batter S, Brown M, Longcope C, McKinlay J, Kantoff PW. Evidence that the CAG Repeat in the androgen receptor gene is associated with the age related decline in serum androgen levels in men. J of Endo 1999; 162: 137-142 download pdf.

Rebbeck TR, Kantoff PW, Krithivas K, Blackwood MA, GodWin AK, Daly MB, Narod Sa, Garber JE, Lynch HT, Weber BL, Brown M. Modification of BRCA1-associated breast cnacer penetrance by the polymorphic androgen receptor CAG repeat. Am J Hum Genet 1999, 64(5): 1371-7 download pdf.

Hanstein B, Liu H, Yancisin M, DiRenzo J, Brown M. Functional analysis of a novel estrogen receptor beta isoform. Mol Endocrinol 1999 Jan; 13(1): 129-37 download pdf.

Shim WS, DiRenzo J, DeCaprio JA, Santen RJ, Brown M, Jeng MH. Segregation of steroid receptor coactivator-1 from steroid receptors in mammary epithelium. Proc Natl Acad Sci 1999 Jan 5; 96(1): 208-213 download pdf.

Febbo PG, Kantoff PW, Giovannucci E, Brown M, Chang G, Hennekens CH, Stampfer M. Debrisoquine hydroxylase (CYP2D6) and prostate cancer. Cancer Epidemiol biomarkers Preven 1998; 7(12): 1075-8 PubMed abstract.

Seol W, Hanstein B, Brown M, Moore DD. Inhibition of estrogen receptor action by the orphan receptor SHP. Mol Endocrinol 1998 Oct; 12(10): 1551-7 PubMed abstract.

Platz E, Giovannucci E, Dahl D, Krithivas K, Brown M, Hennekens C, Stampfer M, Kantoff PW. The GGn repeat in the androgen receptor and prostate cancer risk. Cancer Epidemiol Biomarkers Preven 1998; 7(5): 379-384 PubMed abstract.

Halachmi S. Charaterization and cloning of an estrogen receptor coaxtivator. Ph.D. Thesis, Harvard University, 1997; 126 pages. download pdf.

Neuman E, Ladha MH, Lin N, Upton TM, Miller SJ, DiRenzo J, Pestell RG, Hinds PW, Dowdy SF, Brown M, Ewen ME. Cyclin D1 Stimulation of estrogen receptor transcription independent of cdk4 activation. Mol Cell Biol 1997; 17(9): 5338-5347 download pdf.

Treilleux I, Peloux N, Brown M, Seargeant A. Human estrogen receptor gene promoter P1: estradiol independent activity and estradiol inducibility in ER+ and ER- cells. Mol Endocrinol 1997; 11(9): 1319-1331.

Kantoff PW, Febbo PG, Giovannucci E, Krithivas K, Dahl DM, Chang G, Hennekens CH, Brown M, Stampfer MJ. A polymorphism of the 5 alpha-reductase gene and its association with prostate cancer: a case-control analysis. Cancer Epidemiol Biomarkers Preven 1997; 6(3); 189-192 PubMed abstract.

Tang Z, Treilleux I, Brown M. A transcriptional enhancer required for the differential expression of the human estrogen receptor in breast cancer. Mol Cell Biol 1997; 17(3): 1274-1280 download pdf.

Giovannucci E, Stampfer MJ, Krithivas K, Brown M, Brufsky A, Talcott J, Hennekens Ch, Kantoff PW. The CAG repeat within the androgen receptor and prostate cancer progression. Proc Natl Acad Sci 1997; 94: 3320-3323 PubMed abstract.

Hanstein B, Eckner R, DiRenzo J, Halachmi S, Liu H, Searacy B, Brown M. p300 is a component of an estrogen receptor co-activator complex. Proc Natl Acad Sci 1996; 93(21): 11540-5 download pdf.

Scully R, Ganesan S, Brown M, DeCaprio JA, Cannistra SA, Feunteun J, Schnitt S, Livingston DM. Location of BRCA1 in human breast and ovarian cancer cells. Science 1996; 272: 123-5 PubMed abstract.

Kurokawa R, Söderström M, Hörlein A, Halachmi S, Brown M, Rosenfeld MG, Glass CK. Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature 1995; 377: 451-4 PubMed abstract.

Yu K, Bayona W, Kallen CB, Harding HP, Ravera CP, McMahon G, Brown M, Lazar MA. Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem 1995; 270(41): 23975-83 download pdf.

Halachmi S, Marden E, Martin G, MacKay H, Abbondanza C, Brown M. Estrogen receptor associated proteins: possible mediators of hormone-induced transcription. Science 1994; 264: 1455-8 PubMed abstract.

Segars JH, Marks MS, Hirschfeld S, Driggers PH, Martinez E, Grippo JF, Brown M, Wahli W, Ozato K. Inhibition of estrogen-responsive gene activation by the retinoid X receptor B: evidence for multiple inhibitory pathways. Mol Cell Biol 1993; 13: 2258-68 (author correction, vol. 15, p 3840) PubMed abstract.

Reviews

Krum SA and Brown M. Unraveling estrogen action in osteoporosis. Cell Cycle 2008, 7:10, 1348-52. Download PDF.

Carroll JS and Brown M. Estrogen receptor target gene: an evolving concept. Mol Endocrinology 2006; 8: 1707-14. Download PDF.

Shao W, Brown M. Advances in Estrogen receptor Biology: Prospects for improvements in targeted Breast Cancer Therapy. Review. Breast Cancer Res. 2004; 6(1): 39-52. Download PDF

Miner JN, Brown M. Glucocorticoid Acion. In: Austen S, Burakoff SJ, et al., eds. Therapeutic Immunology, 2^nd edition, Blackwell Science Inc., 2000.

Kantoff P, Giovannucci E, Brown M. The androgen receptor CAG repeat polymorphism and its relationship to prostate cancer. Biochemica et Biophysica Act 1378 (1998) C1- C5.

Brown M. Estrogen Receptor Molecular Biology. In: Henderson IC, Shapiro CL, eds. Hematology/Oncology Clinics of North America, W.B. Saunders Co., 1994; Vol 8, pp101—12

Glass CK, Brown MA. Molecular Mechanisms of Estrogen and Thyroid Hormone Action. In: Noda, M. ed. Molecular and Cellular Biology of Bone, Academic Press 1993: 257—85.