Dipanjan Chowdhury, Ph.D.

Publications

T Chakraborty, D Chowdhury, A Keyes, A Jani, R Subrahmanyam, I Ivanova, R Sen. “Repeat organization and epigenetic regulation of the d(h)-cm domain of the immunoglobulin heavy-chain gene locus.”  Mol Cell. 2007 Sep 7;27(5):842-50 Pubmed ID: 17803947
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed

MA Lee-Kirsch, M Gong, D Chowdhury, L Senenko, K Engel, YA Lee, U de Silva, SL Bailey, T Witte, TJ Vyse, J Kere, C Pfeiffer, S Harvey, A Wong, S Koskenmies, O Hummel, K Rohde, RE Schmidt, AK Dominiczak, M Gahr, T Hollis, FW Perrino, J Lieberman, N Hübner. Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet. 2007 Sep;39(9):1065-7. Pubmed ID: 17660818
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed

MA Lee-Kirsch,  D Chowdhury,  S Harvey , M Gong , L Senenko , Engel K, Pfeiffer C, Hollis T, Gahr M, Perrino FW, Lieberman J, Hubner N.  “A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus.” J Mol Med. 2007 May; 85(5):531-7. PMID: 17440703
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed

D M Dykxhoorn, D Chowdhury, J Lieberman, Chapter: “RNA Interference and Cancer: Endogenous Pathways and Therapeutic Approaches” in Programmed Cell Death in Cancer Progression and Therapy, Springer Science, 2006 (in press)

D Chowdhury, P J Beresford, P Zhu, D Zhang, J Sung, B Demple, F Perrino, J Lieberman, “The Exonuclease TREX1 Is in the SET Complex and Acts in Concert with NM23-H1 to Degrade DNA During Granzyme A-Mediated Cell Death” Mol Cell. 2006 Jul 7;23(1):133-42. PMID: 16818237
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed

P Zhu, D Zhang, D Chowdhury, D Martinvalet, D Keefe, L Shi, J Lieberman, ”Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70”, EMBO Reports, 2006 Apr;7(4):431-7 PMID: 16440001
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed

D Palliser, D Chowdhury, Q-Y Wang, S Lee, R Bronson, D Knipe, J Lieberman,  “An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection,”  Nature 2006 Jan 5;439(7072):89-94. PMID: 16306938
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed

MC Keogh, JA Kim, M Downey, J Fillingham, D Chowdhury, JC Harrison, M Onishi, N Datta, S Galicia, A Emili, J Lieberman, X Shen, S Buratowski, JE Haber, D Durocher, JF Greenblatt, NJ Krogan, “A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery,” Nature 2006 Jan 26;439(7075):497-501 PMID: 16299494
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed

D Chowdhury, MC Keogh, H Ishii, CL Peterson, S Buratowski, J Lieberman, "gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double strand break repair," Mol Cell 2005 Dec 9;20(5):801-9
The significance of this paper and related work (#8) are discussed in a Nature ‘News & Views’ (439:406-7) and Cell ‘Molecular Biology Select’ article (124:227) PMID: 16310392
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed

D Chowdhury, CD Novina, “RNAi and RNA-Based Regulation of Immune System Function,” Adv Immunol 88:267-92, 2005. PMID: 16227093
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed

D Chowdhury, CD Novina, “Potential roles for short RNAs in lymphocytes,” Immunol Cell Biol 83:201-10, 2005. PMID: 15877596
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed

E Song, P Zhu, S-K Lee, D Chowdhury, S Kussman, DM Dykxhoorn, Y Feng, D Palliser, DB Weiner, WA Marasco, P Shankar, J Lieberman, “Antibody-mediated delivery of small interfering RNAs via cell surface receptors,” Nature Biotech 23:709-717, 2005.

H Ishii, D Chowdhury, R Sen, Chapter: “Transcription Regulation in B Cell Development” in Handbook of Stem Cells, Elsevier Science, 2004.

D Chowdhury, R Sen, “Regulation of immunoglobulin heavy-chain gene rearrangements,” Immunol Rev 200:182-96, 2004. PMID: 15242405
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed

D Chowdhury, R Sen, “Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus,” Curr Opin Immunol  16:235-40, 2004. PMID: 15023418
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed

DT Hesslein, DL Pflugh, D Chowdhury, AL Bothwell, R Sen, DG Schatz,  “Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments,” Genes Dev 17:37-42, 2003. PMID: 12514097
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed

D Chowdhury, R Sen, “Transient IL-7/IL-7R Signaling Provides a Mechanism for Feedback Inhibition of Immunoglobulin Heavy Chain Gene Rearrangements,” Immunity 18:229-41, 2003. PMID: 12594950
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed

D Chowdhury, R Sen, “Stepwise activation of the immunoglobulin mu heavy chain gene locus,” EMBO J  20:6394-403, 2001.

J Chaudhuri, D Chowdhury, U Maitra, “Distinct functions of eukaryotic translation initiation factors eIF1A and eIF3 in the formation of the 40 S ribosomal preinitiation complex,”  J Biol Chem 274:17975-80, 1999.